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Condition: Kidney Transplantation
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The mTOR Inhibitor Rapamycin Counteracts Follicle Activation Induced by Ovarian Cryopreservation in Murine Transplantation Models
Conclusions: By adding rapamycin during the OTCTP procedure, we were able to transiently maintain primordial follicles in a quiescent state. This is a promising method for improving the longevity of the ovarian graft. Furthermore, both the ear and kidney capsule transplantation models were suitable for investigating follicle activation and proliferation and pharmacological strategies.PMID:37629764 | PMC:PMC10456585 | DOI:10.3390/medicina59081474
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Jules Bindels Marlyne Squatrito La ëtitia Bernet Michelle Nisolle Laurie Henry Carine Munaut Source Type: research
Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis
CONCLUSIONS: In our cohort, 17% of C3 glomerulopathy/Ig-MPGN cases were associated with rare variants in the CFH, CFI, or C3 genes. In the majority of cases, a quantitative deficiency in factor H or factor I is identified. The presence of a rare variant was associated with poor kidney survival.PMID:37615951 | DOI:10.2215/CJN.0000000000000252
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 24, 2023 Category: Urology & Nephrology Authors: Marie Sophie Meuleman Paula Vieira Martins Carine El Sissy Vincent Audard V éronique Baudouin Dominique Bertrand Frank Bridoux F érielle Louillet Claire Dossier Vincent Esnault No émie Jourde-Chiche Alexandre Karras Marie-Pascale Morin Fran çois Provo Source Type: research
Safety analysis of co-administering tacrolimus and omeprazole in renal transplant recipients - A review
Biomed Pharmacother. 2023 Aug 22;166:115149. doi: 10.1016/j.biopha.2023.115149. Online ahead of print.ABSTRACTTacrolimus is a calcineurin inhibitor used to prevent rejection in allogenic solid organ transplant recipients, which is metabolized in the liver with cytochrome P450 isoforms 3A4 and 3A5 (CYP3A4, CYP3A5). In turn, proton pump inhibitors (PPIs), such as Omeprazole - a substrate and inhibitor of CYP2C19 and CYP3A4 enzymes - are administered to kidney transplant patients in order to prevent duodenal and gastric ulcer disease, associated with the glucocorticoid treatment. Simultaneous administration of both drugs in r...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 24, 2023 Category: Drugs & Pharmacology Authors: Mi łosz Miedziaszczyk Ilona Idasiak-Piechocka Source Type: research
