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Condition: Diabetes Mellitus
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Total 15076 results found since Jan 2013.
Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey
This study provides the current epidemiologic and clinical status of SPS in Japan. The symptom onset to the diagnosis of SPS was longer in patients with high-titer GAD65 antibodies than in those with low-titer GAD65 antibodies. The outcome of patients with SPS was generally favorable, but more aggressive immunotherapies are necessary for GAD65-positive patients with SPS.
Source: Neurology Neuroimmunology and Neuroinflammation - September 22, 2023 Category: Neurology Authors: Matsui, N., Tanaka, K., Ishida, M., Yamamoto, Y., Matsubara, Y., Saika, R., Iizuka, T., Nakamura, K., Kuriyama, N., Matsui, M., Arisawa, K., Nakamura, Y., Kaji, R., Kuwabara, S., Izumi, Y., for the Japanese SPS Study Tags: Autoimmune diseases, Clinical neurology examination, Cohort studies, Prevalence studies Research Article Source Type: research
The role of autophagy in the treatment of type II diabetes and its complications: a review
Type II diabetes mellitus (T2DM) is a chronic metabolic disease characterized by prolonged hyperglycemia and insulin resistance (IR). Its incidence is increasing annually, posing a significant threat to human life and health. Consequently, there is an urgent requirement to discover effective drugs and investigate the pathogenesis of T2DM. Autophagy plays a crucial role in maintaining normal islet structure. However, in a state of high glucose, autophagy is inhibited, resulting in impaired islet function, insulin resistance, and complications. Studies have shown that modulating autophagy through activation or inhibition can...
Source: Frontiers in Endocrinology - September 21, 2023 Category: Endocrinology Source Type: research
Association between urban-rural location and prevalence of type 2 diabetes and impaired fasting glucose in West Africa: a cross-sectional population-based epidemiological study
Conclusion
The prevalence of both T2DM and IFG was more than two times as high in urban areas compared with rural areas in West Africa. Behavioural risk factors are common among urban populations, with ongoing urbanisation expected to drive increases in the prevalence of T2DM. These results could guide planning for T2DM screening, preventive strategies and resource allocation in West Africa.
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Issaka, A., Stevenson, C., Paradies, Y., Houehanou, Y. C. N., Bosu, W. K., Kiwallo, J. B., Wesseh, C. S., Houinato, D. S., Nazoum, D. J. P., Cameron, A. J. Tags: Open access, Cardiovascular medicine Source Type: research
Road map for personalized exercise medicine in T2DM
Trends Endocrinol Metab. 2023 Sep 18:S1043-2760(23)00166-2. doi: 10.1016/j.tem.2023.08.013. Online ahead of print.ABSTRACTThe number of patients with type 2 diabetes mellitus (T2DM) is rising at an alarming rate. Regular physical activity and exercise are cornerstones in the therapy of T2DM. While a one-size-fits-all approach fails to account for many between-subject differences, the use of personalized exercise medicine has the potential of optimizing health outcomes. Here, a road map for personalized exercise therapy targeted at patients with T2DM is presented. It considers secondary complications, glucose management, re...
Source: Trends in Endocrinology and Metabolism: TEM - September 20, 2023 Category: Endocrinology Authors: Christian Brinkmann Source Type: research
Children presenting with diabetes and diabetic ketoacidosis to Emergency Departments during the COVID-19 pandemic in the UK and Ireland: an international retrospective observational study
Conclusions
There were increases in new onset diabetes in children and a higher risk of DKA in the first COVID pandemic year.
Source: Archives of Disease in Childhood - September 19, 2023 Category: Pediatrics Authors: Ponmani, C., Nijman, R. G., Roland, D., Barrett, M., Hulse, T., Whittle, V., Lyttle, M. D., on behalf of Paediatric Emergency Research United Kingdom and Ireland (PERUKI), Irwin, Goyos, Bull, Latif, Ranasinghe, Hartin, Dalzell, Jenkinson, Cantle, Bruce-No Tags: COVID-19 Paediatric Emergency Medicine Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Identification of quality markers for < em > Cyanotis arachnoidea < /em > and analysis of its physiological mechanism based on chemical pattern recognition, network pharmacology, and experimental validation
In this study, ultra-high-performance liquid chromatography (UHPLC) fingerprint combined with chemical pattern recognition were performed, and four differential components were screened out as quality markers, including 20-Hydroxyecdysone, 3-O-acetyl-20-hydroxyecdysone, Ajugasterone C, and 2-O-acetyl-20-hydroxyecdysone. Network pharmacology analysis revealed 107 therapeutic target genes of Cyanotis arachnoidea in DM treatment, and the key targets were Akt1, TNF, IL-6, MAPK3, and JUN. The hypoglycemic mode of action of Cyanotis arachnoidea may be mediated by tumor necrosis factor (TNF) signaling, cancer, insulin resistance,...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Jingnan Hu Yu Feng Baolin Li Fengxia Wang Qi Qian Wei Tian Liying Niu Xinguo Wang Source Type: research
First Report of Klebsiella subsp. Ozaenae Meningitis in Japan
Intern Med. 2023 Sep 15. doi: 10.2169/internalmedicine.1894-23. Online ahead of print.ABSTRACTAlthough the frequency of community-acquired infections caused by Klebsiella pneumoniae subsp. ozaenae (K. ozaenae) is low, they are often detected in sputum specimens. In addition, lung abscesses, necrotizing pneumonia, and urinary tract infections caused by K. ozaenae have also been reported. We herein report the first detection of K. ozaenae as an etiological agent of bacterial meningitis in Japan. Cases of K. ozaenae meningitis complicated by diabetes mellitus and sinusitis have been reported elsewhere. When Klebsiella pneumon...
Source: Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Natsue Hosono Honda Sohei Harada Masahiro Suzuki Yasuhisa Akaiwa Keisuke Miyashita Tomoyuki Miyamoto Kosuke Haruki Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
First Report of Klebsiella subsp. Ozaenae Meningitis in Japan
Intern Med. 2023 Sep 15. doi: 10.2169/internalmedicine.1894-23. Online ahead of print.ABSTRACTAlthough the frequency of community-acquired infections caused by Klebsiella pneumoniae subsp. ozaenae (K. ozaenae) is low, they are often detected in sputum specimens. In addition, lung abscesses, necrotizing pneumonia, and urinary tract infections caused by K. ozaenae have also been reported. We herein report the first detection of K. ozaenae as an etiological agent of bacterial meningitis in Japan. Cases of K. ozaenae meningitis complicated by diabetes mellitus and sinusitis have been reported elsewhere. When Klebsiella pneumon...
Source: Internal Medicine - September 18, 2023 Category: Internal Medicine Authors: Natsue Hosono Honda Sohei Harada Masahiro Suzuki Yasuhisa Akaiwa Keisuke Miyashita Tomoyuki Miyamoto Kosuke Haruki Source Type: research
The prevalence of multimorbidity in virally suppressed HIV-positive patients in Limpopo
Conclusion: There is a high prevalence, both of risk factors for NCDs and multimorbidity (> 1 chronic disease) in patients who are ≥ 40 years and virologically suppressed on ART.
Source: Southern African Journal of HIV Medicine - September 18, 2023 Category: African Health Authors: Limakatso Lebina Source Type: research
Contemporary practices of blood glucose management in diabetic patients: a survey of hyperbaric medicine units in Australia and New Zealand
CONCLUSIONS: This survey highlights the burden of diabetes on patients treated with HBOT and identifies considerable variability in practices which may benefit from further study to optimise management of these patients.PMID:37718297 | DOI:10.28920/dhm53.3.230-236
Source: Diving and Hyperbaric Medicine - September 17, 2023 Category: Sports Medicine Authors: Brenda R Laupland Kevin Laupland Kenneth Thistlethwaite Robert Webb Source Type: research
