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Condition: Diabetes Mellitus

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Total 45646 results found since Jan 2013.

BMP (Bone Morphogenetic Protein) 9/Alk1 (Activin-Like Kinase Receptor Type I) Signaling Prevents Hyperglycemia-Induced Vascular Permeability.
CONCLUSIONS: From these data, we suggest that by preventing retinal vascular permeability, BMP9 could serve as a novel therapeutic agent for diabetic macular edema. PMID: 29880487 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 7, 2018 Category: Cardiology Authors: Akla N, Viallard C, Popovic N, Lora Gil C, Sapieha P, Larrivée B Tags: Arterioscler Thromb Vasc Biol Source Type: research

Thermotherapy: Improving the vascular access cannulation procedure.
CONCLUSION:: (1) Thermotherapy on the vascular access reduced the pain caused by needle cannulation in our patients, without complications related to vascular access. (2) We will consider its clinical application in those painful vascular access cannulations at our hemodialysis unit. (3) Further studies are required to assess other potential beneficial effects added to thermotherapy in vascular access cannulation procedure. PMID: 30442083 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - November 18, 2018 Category: Surgery Tags: J Vasc Access Source Type: research

Arterial Stiffness: A Focus on Vascular Calcification and Its Link to Bone Mineralization.
Abstract This review focuses on the association between vascular calcification and arterial stiffness, highlighting the important genetic factors, systemic and local microenvironmental signals, and underlying signaling pathways and molecular regulators of vascular calcification. Elevated oxidative stress appears to be a common procalcification factor that induces osteogenic differentiation and calcification of vascular cells in a variety of disease conditions such as atherosclerosis, diabetes mellitus, and chronic kidney disease. Thus, the role of oxidative stress and oxidative stress-regulated signals in vascular...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 1, 2020 Category: Cardiology Authors: Chen Y, Zhao X, Wu H Tags: Arterioscler Thromb Vasc Biol Source Type: research

Incidence and prognosis of vascular complications after transcatheter aortic valve implantation
Conclusions: Vascular complications affect perioperative management and outcomes following TAVI. Our findings show that these complications often require urgent surgical or endovascular repair and result in increased blood transfusions, greater length of hospital stay, and significantly increased costs. Diabetes mellitus and logistic European System for Cardiac Operative Risk Evaluation may be predictive of VAC and should be considered during TAVI patient selection.
Source: Journal of Vascular Surgery - August 29, 2013 Category: Surgery Authors: Bibombe P. Mwipatayi, Alarick Picardo, Taolo Vijay Masilonyane-Jones, Robert Larbalestier, Shannon Thomas, Jennifer Turner, Vikram Vijayan, Gerald Yong Tags: Clinical research studies Source Type: research

Deficient eNOS Phosphorylation Is a Mechanism for Diabetic Vascular Dysfunction Contributing to Increased Stroke Size Basic Sciences
Conclusions— Diminished eNOS phosphorylation is a mechanism of vascular dysfunction in db/db mice. We show here that modulation of the eNOS S1176 phosphorylation site in db/db mice is associated with improved vascular reactivity and improved outcome to stroke after middle cerebral artery occlusion.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Li, Q., Atochin, D., Kashiwagi, S., Earle, J., Wang, A., Mandeville, E., Hayakawa, K., d'Uscio, L. V., Lo, E. H., Katusic, Z., Sessa, W., Huang, P. L. Tags: Animal models of human disease, Genetically altered mice, Type 2 diabetes, Acute Cerebral Infarction, Endothelium/vascular type/nitric oxide Basic Sciences Source Type: research

Three-Dimensional Vascular Network Assembly From Diabetic Patient-Derived Induced Pluripotent Stem Cells.
CONCLUSIONS: Using our robust protocol, we can direct efficient differentiation of T1D-hiPSC to EVCs. Early endothelial cells derived from T1D-hiPSC are functional when mature. T1D-EVCs self-assembled into 3D networks when embedded in hyaluronic acid and hypoxia-inducible hydrogels. The capability of T1D-EVCs to assemble into 3D networks in engineered matrices and to respond to a hypoxic microenvironment is a significant advancement for autologous vascular therapy in diabetic patients and has broad importance for tissue engineering. PMID: 26449749 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 8, 2015 Category: Cardiology Authors: Chan XY, Black R, Dickerman K, Federico J, Levesque M, Mumm J, Gerecht S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Abstract P200: Endothelial Estrogen Receptor Alpha Does Not Protect Female Mice Against Western Diet Induced Vascular Stiffness Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness
Conclusion: Endothelial ERα does not protect females from vascular stiffness induced by a WD. Indeed, the present data suggest a predisposition toward protection of rodent lacking ERα in conditions of insulin resistance.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Manrique, C., Lastra, G., Haertling, D., DeMarco, V., Aroor, A., Jia, G., Ramirez-Perez, F. I., Martinez-Lemus, L., Karas, R., Chambon, P., Sowers, J. Tags: Session Title: Receptors and Signal Transduction/Vascular Biology and Stiffness Source Type: research

Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase-Dependent Mechanisms Diabetes and Vascular Function
In conclusion, Rho kinase activation, via NOX1-derived ROS and downregulation of Nrf2 system, impairs IPA function in DM. These data suggest that Nrf2 is vasoprotective in DM-associated erectile dysfunction.
Source: Hypertension - September 6, 2016 Category: Cardiology Authors: Alves-Lopes, R., Neves, K. B., Montezano, A. C., Harvey, A., Carneiro, F. S., Touyz, R. M., Tostes, R. C. Tags: Vascular Disease Diabetes and Vascular Function Source Type: research

Internal Pudental Artery Dysfunction in Diabetes Mellitus Is Mediated by NOX1-Derived ROS-, Nrf2-, and Rho Kinase-Dependent MechanismsNovelty and Significance Diabetes and Vascular Function
In conclusion, Rho kinase activation, via NOX1-derived ROS and downregulation of Nrf2 system, impairs IPA function in DM. These data suggest that Nrf2 is vasoprotective in DM-associated erectile dysfunction.
Source: Hypertension - September 6, 2016 Category: Cardiology Authors: Alves-Lopes, R., Neves, K. B., Montezano, A. C., Harvey, A., Carneiro, F. S., Touyz, R. M., Tostes, R. C. Tags: Vascular Disease Original Articles Source Type: research

Use of p53-Silenced Endothelial Progenitor Cells to Treat Ischemia in Diabetic Peripheral Vascular Disease Vascular Medicine
ConclusionsTransient silencing of p53 using adenoviral vector in EPCs may have a therapeutic role in diabetic peripheral vascular disease.
Source: JAHA:Journal of the American Heart Association - April 1, 2017 Category: Cardiology Authors: Kundu, N., Domingues, C. C., Chou, C., Ahmadi, N., Houston, S., Jerry, D. J., Sen, S. Tags: Gene Therapy, Stem Cells, Diabetes, Type 1, Diabetes, Type 2, Peripheral Vascular Disease Original Research Source Type: research

Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis.
CONCLUSIONS: These novel findings demonstrate that DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling. PMID: 29930002 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 21, 2018 Category: Cardiology Authors: Lino M, Wan MH, Rocca AS, Ngai D, Shobeiri N, Hou G, Ge C, Franceschi RT, Bendeck MP Tags: Arterioscler Thromb Vasc Biol Source Type: research

Extracellular vesicles and insulin resistance: a potential interaction in vascular dysfunction.
Abstract Insulin resistance plays a key role in cardiovascular complications associated with diabetes mellitus and hypertensive disorders. In states of insulin resistance several circulating factors may contribute to a defective insulin sensitivity in different tissues, including the vasculature. One of these factors influencing the vascular insulin resistance are the extracellular vesicles. The extracellular vesicles include exosomes, microvesicles, and apoptotic bodies which are released to the circulation by different vascular cells. Since the cargo of extracellular vesicles seems to be altered in metabolic com...
Source: Current Vascular Pharmacology - October 1, 2018 Category: Drugs & Pharmacology Authors: Saez T, Toledo F, Sobrevia L Tags: Curr Vasc Pharmacol Source Type: research

KLF11 (Kru üppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
Conclusions- Our data demonstrate that KLF11 is a novel transcriptional suppressor of F3 in vascular smooth muscle cells, constituting a potential molecular target for inhibition of arterial thrombosis. PMID: 30602303 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 3, 2019 Category: Cardiology Authors: Liang W, Fan Y, Lu H, Chang Z, Hu W, Sun J, Wang H, Zhu T, Wang J, Adili R, Garcia-Barrio MT, Holinstat M, Eitzman D, Zhang J, Chen YE Tags: Arterioscler Thromb Vasc Biol Source Type: research

Current state of vascular access in Singapore.
This article described the current state of vascular access management for patients with end-stage renal disease in Singapore. Over the past 10 years, there has been a change in the demographics of end-stage renal disease patients. Aging population and the increase in prevalence of diabetes mellitus has led to the acceleration of chronic kidney disease and increase in incidence and prevalence of end-stage renal disease. Vascular access care has, therefore, been more complicated, with the physical, psychological, and social challenges that occur with increased frequency in elderly patients and patients with multiple co-mo...
Source: The Journal of Vascular Access - September 28, 2019 Category: Surgery Tags: J Vasc Access Source Type: research

Analysis of systemic risk factors between diabetic/vascular patients having primary lower limb amputations and re-amputations
Conclusions: Factors that were significantly correlated with increased re-amputation rates have a clear pathologic pathway that affects vascularity and wound healing. Further studies should be aimed at developing a clear scoring system that can be used to stratify patient for re-amputation risk, and to better predict the results according to the severity of diabetes.PMID:37552100 | DOI:10.1177/17085381231194964
Source: Vascular - August 8, 2023 Category: Surgery Authors: Kaissar Yammine Joeffroy Otayek Emil Haikal Mohammad Daher Anthony El Alam Karl Boulos Chahine Assi Source Type: research