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Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes
CONCLUSIONS: These findings suggest that reelin inhibition may provide a novel therapeutic approach to counteract leukocyte or monocyte adhesion as well as extravasation and inhibit the progression of atherosclerosis. This strategy may also be relevant for other diseases that involve leukocyte or monocyte extravasation as a central pathological mechanism, such as multiple sclerosis or arthritis.PMID:33626909 | DOI:10.1161/ATVBAHA.121.316000
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 25, 2021 Category: Cardiology Authors: Laurent Calvier Xunde Xian Richard Lee Anastasia Sacharidou Chieko Mineo Philip W Shaul Maria Z Kounnas Shirling Tsai Joachim Herz Source Type: research

Effect of miR-663 on atherosclerosis by regulating the proliferation of vascular smooth muscle cells in lipid plaques
CONCLUSION: miR-663 targeted HMGA2 to inhibit VSMC proliferation and AS development, which may offer insights into AS treatment.PMID:35599617 | DOI:10.1177/17085381221098826
Source: Vascular - May 23, 2022 Category: Surgery Authors: Zhisheng Deng Lihua Li Source Type: research

Pivotal Role of Serum- and Glucocorticoid-Inducible Kinase 1 in Vascular Inflammation and Atherogenesis.
CONCLUSIONS: SGK1 plays a pivotal role in vascular inflammation during atherogenesis. SGK1 participates in the regulation of monocyte/macrophage migration and MMP-9 transcription via regulation of nuclear factor-κB. PMID: 25614279 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 22, 2015 Category: Cardiology Authors: Borst O, Schaub M, Walker B, Schmid E, Muenzer P, Voelkl J, Alesutan I, Rodríguez JM, Vogel S, Schoenberger T, Metzger K, Rath D, Umbach A, Kuhl D, Müller II, Seizer P, Geisler T, Gawaz M, Lang F Tags: Arterioscler Thromb Vasc Biol Source Type: research

Is targeting microRNAs the philosopher's stone for vascular disease?
Abstract MicroRNAs (miRs) are small non-coding regulatory RNAs that control gene expression. They are involved in the pathogenesis of several diseases, including vascular and cardiac diseases. Their involvement is related to alterations of lipid metabolism, endothelial dysfunction, vascular smooth muscle cell phenotype, atherosclerosis-related low-grade inflammation of the arteries, cardiac hypertrophy or remodelling and heart failure. The manipulation of miRs may eventually be used to prevent or treat vascular or cardiac disease. Available drugs (some statins and renin-angiotensin-system inhibitors, alone or in c...
Source: Current Vascular Pharmacology - March 31, 2015 Category: Drugs & Pharmacology Authors: Athyros VG, Katsiki N, Karagiannis A Tags: Curr Vasc Pharmacol Source Type: research

Oxidative Stress In Chronic Vascular Disease: From Prediction To Prevention.
Abstract This review article is intended to describe the strong relationship between oxidative stress and vascular disease. Reactive oxygen species (ROS) play an important role in the pathogenesis of vascular disease: oxidative stress is intimately linked to atherosclerosis, through oxidation of LDL and endothelial dysfunction, to diabetes, mainly through advanced glycation end-products (AGEs)/receptor for AGE (RAGE) axis impairment, protein kinase C (PKC), aldose reductase (AR) and NADPH oxidase (NOX) dysfunction, and to hypertension, through renin-angiotensin system (RAS) dysfunction. Several oxidative stress bi...
Source: Vascular Pharmacology - September 9, 2015 Category: Drugs & Pharmacology Authors: Santilli F, D'Ardes D, Davì G Tags: Vascul Pharmacol Source Type: research

Vascular Inflammation Evaluated by 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Is Associated With Endothelial Dysfunction.
CONCLUSIONS: The present study showed that vascular inflammation in the carotid arteries evaluated by [(18)F]-fluorodeoxyglucose-positron emission tomography/computed tomography was one of the independent correlates of decreased %FMD, thus suggesting the association of vascular inflammation with endothelial dysfunction in humans. PMID: 27386941 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 6, 2016 Category: Cardiology Authors: Honda A, Tahara N, Nitta Y, Tahara A, Igata S, Bekki M, Nakamura T, Sugiyama Y, Kaida H, Kurata S, Fujimoto K, Abe T, Enomoto M, Adachi H, Narula J, Yamagishi SI, Fukumoto Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Early Diagnosis of Vascular Cognitive Impairment Leads to Improved Treatment of Vascular Risk Factors (P2.095)
Conclusions:Medical management of vascular risk factors improves in patients with undiagnosed early VCI following a diagnosis of VaMCI and implementation of educational and caregiver strategies. These results suggest that early diagnosis and increased education and supervision regarding treatment through an enhanced partnership with patients and families may benefit individuals at higher risk for future cerebrovascular events.Study Supported by:American Heart Association (15GRNT25270010), NIH (NIGMS U54GM104938) and the VA Clinical Science Research & Development Service (CX000340).Disclosure: Dr. Kirkpatrick has nothin...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kirkpatrick, A., Vincent, A., Ross, E., Prodan, C. Tags: Vascular Disease and Dementia Source Type: research

Efficacy of statin on vascular access patency in diabetic hemodialysis patients.
CONCLUSIONS: Statin treatment could be associated with improved vascular access dysfunction among diabetic hemodialysis patients. PMID: 28604988 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - June 14, 2017 Category: Surgery Tags: J Vasc Access Source Type: research

LncRNAs in vascular biology and disease.
Abstract Accumulating studies indicate that long non-coding RNAs (lncRNAs) play important roles in the regulation of diverse biological processes involved in homeostatic control of the vessel wall in health and disease. However, our knowledge of the mechanisms by which lncRNAs control gene expression and cell signaling pathways is still nascent. Furthermore, only a handful of lncRNAs has been functionally evaluated in response to pathophysiological stimuli or in vascular disease states. For example, lncRNAs may regulate endothelial dysfunction by modulating endothelial cell proliferation (e.g. MALAT1, H19) or angi...
Source: Vascular Pharmacology - February 6, 2018 Category: Drugs & Pharmacology Authors: Simion V, Haemmig S, Feinberg MW Tags: Vascul Pharmacol Source Type: research

Statin therapy improved long-term prognosis in patients with major non-cardiac vascular surgeries: a systematic review and meta-analysis.
CONCLUSIONS: This meta-analysis demonstrated that statin therapy was associated with improved survival rates and patency rates and with reduced cardiovascular or stroke morbidities in patients who underwent non-cardiac vascular surgeries. PMID: 29953967 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - June 25, 2018 Category: Drugs & Pharmacology Authors: Yu W, Wang B, Zhan B, Li Q, Li Y, Zhu Z, Yan Z Tags: Vascul Pharmacol Source Type: research

Inhibition of Vascular Calcification.
Conclusions- Our study demonstrates that teniposide reduces vascular calcification by regulating p53-(miR-203-3p)-BMP2 signaling pathway, which contributes to the antiatherogenic properties of Topo II inhibitors. PMID: 30354214 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 1, 2018 Category: Cardiology Authors: Liu L, Zeng P, Yang X, Duan Y, Zhang W, Ma C, Zhang X, Yang S, Li X, Yang J, Liang Y, Han H, Zhu Y, Han J, Chen Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Impact of Adding Aspirin to Beta-Blocker and Statin in High-Risk Patients Undergoing Major Vascular Surgery
In this study we evaluated the benefits of adding aspirin (A) to BB and S (ABBS), with/without angiotensin-converting enzyme inhibitor (ACE-I) on postoperative outcome in high-risk patients undergoing major vascular surgery.Methods: Analysis of consecutive patients undergoing elective vascular surgery at the University of Michigan Cardiovascular Center was performed. Univariate and multivariate analyses were done using cardiac risk index [Revised Cardiac Risk Index (RCRI), coronary artery disease (CAD), insulin-dependent diabetes mellitus (IDDM), cerebral vascular disease, renal dysfunction, congestive heart failure, and m...
Source: Annals of Vascular Surgery - March 25, 2013 Category: Surgery Authors: Wei C. Lau, James B. Froehlich, Elizabeth S. Jewell, Daniel G. Montgomery, Kristina M. Eng, Theresa A. Shields, Peter K. Henke, Kim A. Eagle Tags: Basic Data Underlying Clinical Decision-Making in Endovascular Therapy Source Type: research