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Condition: Obesity
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Total 77257 results found since Jan 2013.
Metformin alleviates monoamine oxidase-related vascular oxidative stress and endothelial dysfunction in rats with diet-induced obesity
In conclusion, METF elicited vascular protective effects via the mitigation of MAO-related oxidative stress in the rat model of diet-induced obesity.PMID:34216348 | DOI:10.1007/s11010-021-04194-2
Source: Molecular and Cellular Biochemistry - July 3, 2021 Category: Biochemistry Authors: Loredana N Ionic ă Laura Gai ță Anca M B înă Raluca So șdean Rodica Lighezan Alexandra Sima Daniel Mali ța Octavian M Cre țu Ovidiu Burlacu Danina M Muntean Adrian Sturza Source Type: research
Differential Contribution of Renal Cytochrome P450 Enzymes to Kidney Endothelial Dysfunction and Vascular Oxidative Stress in Obesity
Biochem Pharmacol. 2021 Nov 22:114850. doi: 10.1016/j.bcp.2021.114850. Online ahead of print.ABSTRACTArachidonic acid (AA)-derived cytochrome P450 (CYP) derivatives, epoxyeicosatrienoic acids (EETs) and 20-hidroxyeicosatetranoic acid (20-HETE), play a key role in kidney tubular and vascular functions and blood pressure. Altered metabolism of CYP epoxygenases and CYP hydroxylases has differentially been involved in the pathogenesis of metabolic disease-associated vascular complications, although the mechanisms responsible for the vascular injury are unclear. The present study aimed to assess whether obesity-induced changes ...
Source: Biochemical Pharmacology - November 25, 2021 Category: Drugs & Pharmacology Authors: Mercedes Mu ñoz Elvira L ópez-Oliva Est éfano Pinilla Claudia Rodr íguez Mar ía Pilar Martínez Cristina Contreras Alfonso G ómez Sara Benedito Javier S áenz-Medina Luis Rivera Dolores Prieto Source Type: research
Cystamine reduces vascular stiffness in Western diet-fed female mice
Am J Physiol Heart Circ Physiol. 2021 Dec 10. doi: 10.1152/ajpheart.00431.2021. Online ahead of print.ABSTRACTConsumption of diets high in fat, sugar and salt (Western diet, WD) is associated with accelerated arterial stiffening, a major independent risk factor for cardiovascular disease (CVD). Obese women are more prone to develop arterial stiffening leading to more frequent and severe CVD compared to men. As tissue transglutaminase (TG2) has been implicated in vascular stiffening, our goal herein was to determine the efficacy of cystamine, a non-specific TG2 inhibitor, at reducing vascular stiffness in female mice chroni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 10, 2021 Category: Physiology Authors: Francisco I Ramirez-Perez Francisco J Cabral-Amador Adam T Whaley-Connell Annayya R Aroor Mariana Morales-Quinones Makenzie L Woodford Thaysa Ghiarone Larissa Ferreira-Santos Thomas J Jurrissen Camila M Manrique-Acevedo Guanghong Jia Vincent G Demarco Jau Source Type: research
The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity
CONCLUSIONS: Treatment with lomitapide attenuated the increase in body weight in mice with obesity and restored the lipid profile and vascular function. These effects were accompanied by a decrease in inflammation and oxidative stress.PMID:35253407 | DOI:10.1002/oby.23389
Source: Obesity - March 7, 2022 Category: Eating Disorders & Weight Management Authors: Undral Munkhsaikhan Youngin Kwon Amal M Sahyoun Karima Ait-Aissa Adam Kassan Modar Kassan Source Type: research
Atherosclerosis Vascular Endothelial Secretion Dysfunction and Smooth Muscle Cell Proliferation
This article aims to study the dysregulation of atherosclerotic vascular endothelial secretion and smooth muscle cell proliferation, and put forward and practice the pathological research of atherosclerotic disease. This article describes in detail atherosclerosis, endothelial dysfunction, and smooth muscle cell proliferation, and studies the causes of atherosclerosis. Research results indicate that atherosclerotic vascular endothelial dysfunction also has a great influence on the proliferation of smooth muscle cells. Many genes and environmental factors can regulate the functions of endothelial cells, vascular smooth musc...
Source: Atherosclerosis - March 21, 2022 Category: Cardiology Authors: Junxi Li Xinying Fu Renyi Yang Wei Zhang Source Type: research
Role of Chemerin/ChemR23 axis as an emerging therapeutic perspective on obesity-related vascular dysfunction
J Transl Med. 2022 Mar 22;20(1):141. doi: 10.1186/s12967-021-03220-7.ABSTRACTSufficient epidemiological investigations demonstrate that there is a close correlation between obesity and vascular dysfunction. Nevertheless, specific mechanisms underlying this link remain currently unclear. Given the crucial and decisive role of vascular dysfunction in multitudinous diseases, various hypotheses had been proposed and numerous experiments were being carried out. One recognized view is that increased adipokine secretion following the expanded mass of white adipose tissue due to obesity contributes to the regulation of vascular fu...
Source: Atherosclerosis - March 23, 2022 Category: Cardiology Authors: Yingying Xie Ling Liu Source Type: research
