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Total 62491 results found since Jan 2013.

Identifying and Describing the Impact of Cyclone, Storm and Flood Related Disasters on Treatment Management, Care and Exacerbations of Non-communicable Diseases and the Implications for Public Health
Conclusion Cyclone, flood and storm related disasters impact on treatment management and overall care for people with NCDs. This results in an increased risk of exacerbation of illness or even death. The interruption may be caused by a range of factors, such as damaged transport routes, reduced health services, loss of power and evacuations. The health impact varies according to the NCD. For people with chronic respiratory diseases, a disaster increases the risk of acute exacerbation. Meanwhile, for people with cancer, cardiovascular diseases and diabetes there is an increased risk of their illness exacerbating, which can ...
Source: PLOS Currents Disasters - September 28, 2015 Category: Global & Universal Authors: jc164421 Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review
ConclusionBerberine could impede the development of dementia via multiple mechanisms: preventing brain damages and enhancing cognition directly in the brain, and indirectly through alleviating risk factors such as metabolic dysfunction, and cardiovascular, kidney and liver diseases. This study provided evidence to support the value of berberine in the prevention of dementia associated with MetS.
Source: Journal of Integrative Medicine - January 17, 2020 Category: Complementary Medicine Source Type: research

Seasonal trends in hypertension in Poland: evidence from Google search engine query data.
CONCLUSIONS: In conclusion, hypertension is more likely to occur during winter months, which correlates with increased interest in searching phrase 'hypertension' in Google. PMID: 29297185 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - January 3, 2018 Category: Cardiology Authors: Płatek AE, Sierdziński J, Krzowski B, Szymański FM Tags: Kardiol Pol Source Type: research

Placental location site and adverse antepartum pregnancy complications: a meta-analysis and review of the literature
ConclusionCentral and fundal location sites and central location alone decreased the risk of hypertension during pregnancy. Low uterine segment location sites increased the risk for APH. There were no effects of placenta location sites on the development of GDM, PPROM, PTD or abruption.
Source: Archives of Gynecology and Obstetrics - April 17, 2022 Category: OBGYN Source Type: research

Calcium channel blockers for pulmonary arterial hypertension.
CONCLUSIONS: Currently, as there is lack of valid evidence, the efficacy and safety of CCBs is unproven in the treatment of PAH. However, the search strategy used for this review did identify four controlled clinical trials without randomization, three of which suggested treatment with CCBs may be beneficial in PAH. No adverse side effects of CCBs were reported. Confirmation of these findings by RCTs is recommended. PMID: 26407098 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 25, 2015 Category: Journals (General) Authors: Fan Z, Chen Y, Liu H Tags: Cochrane Database Syst Rev Source Type: research

Interventions for reducing inflammation in familial Mediterranean fever.
CONCLUSIONS: There were limited RCTs assessing interventions for people with familial Mediterranean fever. Based on the evidence, three times daily colchicine appears to reduce the number of people experiencing attacks, colchicine single dose and divided dose might not be different for children with familial Mediterranean fever and anakinra might reduce C-reactive protein in colchicine-resistant participants; however, only a few RCTs contributed data for analysis. Further RCTs examining active interventions, not only colchicine, are necessary before a comprehensive conclusion regarding the efficacy and safety of interventi...
Source: Cochrane Database of Systematic Reviews - October 19, 2018 Category: General Medicine Authors: Wu B, Xu T, Li Y, Yin X Tags: Cochrane Database Syst Rev Source Type: research

Outcomes of pregnancies using donor sperm compared with those using partner sperm: systematic review and meta-analysis
The objective of this study was to establish whether pregnancies conceived using donor sperm are at higher risk of obstetric and perinatal complications than those conceived with partner sperm. As more treatments are being carried out using donor sperm, attention is being given to obstetric and perinatal outcomes, as eventsin utero and at delivery have implications for long-term health. There is a need to know if there is any difference in the outcomes of pregnancies between those conceived using donor versus partner sperm in order to adequately inform and counsel couples.SEARCH METHODSWe performed a systematic review and ...
Source: Human Reproduction Update - October 15, 2020 Category: OBGYN Source Type: research

Pathways to Pulmonary Hypertension In Sickle Cell Disease: The Search For Prevention And Early Intervention.
Authors: Shilo NR, Morris CR Abstract INTRODUCTION: Pulmonary hypertension (PH) develops in a significant number of patients with sickle cell disease (SCD), resulting in increased morbidity and mortality. This review focuses on PH pathophysiology, risk stratification, and new recommendations for screening and treatment for patients with SCD. Areas covered: An extensive PubMed literature search was performed. While the pathophysiology of PH in SCD is yet to be fully deciphered, it is known that the etiology is multifactorial; hemolysis, hypercoagulability, hypoxemia, ischemic-reperfusion injury, oxidative stress, an...
Source: Expert Review of Hematology - August 19, 2017 Category: Hematology Tags: Expert Rev Hematol Source Type: research

Efficacy and Safety of Direct Oral Anticoagulants in Patients with Cirrhosis-- Single Institution Experience
Conclusions:Our study is the largest series of patients with cirrhosis treated with DOACs. Bleeding complications with DOAC use in this population is high. Providers considering starting DOACs in patients with cirrhosis should consider the risk of bleeding in this population.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Cisak, K. I., Asante, D., Grill, D. E., Ashrani, A. A. Tags: 332. Antithrombotic Therapy: Poster II Source Type: research

Universal HIV Testing and Treatment (UTT) Integrated with Chronic Disease Screening and Treatment: the SEARCH study
AbstractPurpose of ReviewThe growing burden of untreated chronic disease among persons with HIV (PWH) threatens to reverse heath gains from ART expansion. Universal test and treat (UTT) ’s population-based approach provides opportunity to jointly identify and treat HIV and other chronic diseases. This review’s purpose is to describe SEARCH UTT study’s integrated disease strategy and related approaches in Sub-Saharan Africa.Recent FindingsIn SEARCH, 97% of adults were HIV tested, 85% were screened for hypertension, and 79% for diabetes at health fairs after 2  years, for an additional $1.16/person. After 3 years, po...
Source: Current HIV/AIDS Reports - June 7, 2020 Category: Infectious Diseases Source Type: research

Comparison of the Effect of Combination Therapy with an Angiotensin II Receptor Blocker and Either a Low-Dose Diuretic or Calcium Channel Blocker on Cardiac Hypertrophy in Patients with Hypertension.
Abstract Left ventricular hypertrophy (LVH) regression is an important issue in hypertensive patients. Patients with LVH who had received the angiotensin receptor blocker (ARB) treatment for 8 weeks and had not reached the target blood pressure level were enrolled in the study. Patients were assigned to either losartan (50 mg)/hydrochlorothiazide (HCTZ, 12.5 mg) group or ARB + CCB group (usual dose of ARB and calcium channel blocker, CCB). After 48 weeks, LV mass index was found to be reduced significantly in the losartan/HCTZ group but not in the ARB + CCB group. These results suggest that combination thera...
Source: Clinical and Experimental Hypertension - February 12, 2013 Category: Cardiology Authors: Okura T, Miyoshi KI, Irita J, Enomoto D, Jotoku M, Nagao T, Watanabe K, Matsuoka H, Ashihara T, Higaki J, for Ehime Study, Effect of Anti-hypertensive therapy on Regression of Cardiac Hypertrophy (E-SEARCH) trial investigators Tags: Clin Exp Hypertens Source Type: research

Does induction of labour increase the risk of caesarean section? A systematic review and meta-analysis of trials in women with intact membranes.
CONCLUSIONS: Induction of labour in women with intact membranes reduces the risk of caesarean section. Review of the trials suggests that this effect may arise from non-treatment effects, and that additional trials are needed. PMID: 23834460 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 3, 2013 Category: OBGYN Authors: Wood S, Cooper S, Ross S Tags: BJOG Source Type: research

Oral antihypertensive therapy for severe hypertension in pregnancy and postpartum: a systematic review
ConclusionsOral nifedipine, and possibly labetalol and methyldopa, are suitable options for treatment of severe hypertension in pregnancy/postpartum.
Source: BJOG: An International Journal of Obstetrics and Gynaecology - May 16, 2014 Category: OBGYN Authors: T Firoz, LA Magee, K MacDonell, BA Payne, R Gordon, M Vidler, P Dadelszen, Tags: Systematic Review Source Type: research