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Condition: Hypertension

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Total 86915 results found since Jan 2013.

Non-high-density lipoprotein cholesterol and treatment targets in vascular surgery patients
DISCUSSION: Among vascular surgery patients, over half did not meet non-HDL targets. These results suggest that we may be vastly under-performing adequate medical optimization with only about one-fourth of patients on a statin at their final encounter and approximately one-tenth of patients being treated with a high-intensity statin. With recent evidence supporting non-HDL as a valuable measurement for atherosclerotic risk, there is potential to optimize medical management beyond current high-intensity statin therapy. Further investigation is needed regarding the risk of adverse events between patients treated with these v...
Source: Vascular - September 16, 2022 Category: Surgery Authors: Drew J Braet Kian Pourak Vibav Mouli Itai Palmon Dan Dinh Nicholas H Osborne Chandu Vemuri Eric J Brandt Source Type: research

Extracellular vesicle-mediated miR135a-5p transfer in hypertensive rat contributes to vascular smooth muscle cell proliferation via targeting FNDC5
Conclusions Increased miR135a-5p in the SHR-EVs promoted VSMC proliferation of WKY and SHR via inhibiting FNDC5 expression. MiR135a-5p and FNDC5 are crucial targets for intervention of VSMC proliferation in hypertension.PMID:33865997 | DOI:10.1016/j.vph.2021.106864
Source: Vascular Pharmacology - April 18, 2021 Category: Drugs & Pharmacology Authors: Ying Tong Chao Ye Fen Zheng Jin-Hua Bo Lu-Lu Wu Ying Han Ye-Bo Zhou Xiao-Qing Xiong Qi Chen Yue-Hua Li Yu-Ming Kang Guo-Qing Zhu Source Type: research

Prenatal exercise reprograms the development of hypertension progress and improves vascular health in SHR offspring
CONCLUSIONS: These data suggest that prenatal exercise improves the vascular function by the hypermethylation of CACNA1C in the arterial myocytes and delays the development of hypertension in the offspring of SHRs. However, these effects fade out with age.PMID:34116258 | DOI:10.1016/j.vph.2021.106885
Source: Vascular Pharmacology - June 11, 2021 Category: Drugs & Pharmacology Authors: Shanshan Li Yu Chen Yanyan Zhang Fang Qiu Fanxing Zeng Lijun Shi Source Type: research

Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling
CONCLUSIONS: These findings provide novel molecular insight into HS-induced structural changes in eGC and EC composition that may increase cardiovascular risk and potentially guide the development of new diagnostics and therapeutic interventions.PMID:36700429 | DOI:10.1161/ATVBAHA.122.318439
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 26, 2023 Category: Cardiology Authors: Arada Vinaiphat Kalailingam Pazhanchamy Gnanasekaran JebaMercy SoFong Cam Ngan Melvin Khee-Shing Leow Hee Hwa Ho Yong-Gui Gao Kah Leong Lim A Mark Richards Dominique P V de Kleijn Christopher P Chen Raj N Kalaria Jian Liu Deborah D O'Leary Neil E McCarthy Source Type: research

Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II-Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling Renin-Angiotensin System
In conclusion, the key counter-regulatory role of ACE2 against an activated renin–angiotensin system provides novel insights into the role of ACE2 in vascular diseases.
Source: Hypertension - June 11, 2014 Category: Cardiology Authors: Patel, V. B., Zhong, J.-C., Fan, D., Basu, R., Morton, J. S., Parajuli, N., McMurtry, M. S., Davidge, S. T., Kassiri, Z., Oudit, G. Y. Tags: Other Vascular biology Renin-Angiotensin System Source Type: research

A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension
Conclusions These results indicate that Egr-1 governs pulmonary vascular remodelling and the development of characteristic vascular neointimal lesions in flow-associated PAH. Egr-1 is therefore a potential target for future PAH treatment.
Source: Cardiovascular Research - August 26, 2014 Category: Cardiology Authors: Dickinson, M. G., Kowalski, P. S., Bartelds, B., Borgdorff, M. A. J., van der Feen, D., Sietsma, H., Molema, G., Kamps, J. A. A. M., Berger, R. M. F. Tags: Vascular biology Source Type: research

Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.
Abstract The Renin-Angiotensin system plays an important role in the regulation of systemic blood pressure as well as in fluid and electrolyte balance. It is divided into two described axes, the ACE - Ang II - AT1 receptor, with Ang II as the main mediator, and the ACE2 - Ang-(1-7) - Mas receptor, with Ang-(1-7) responsible for the main effects. The main vascular effect induced by Ang II is contraction, while Ang-(1-7) includes relaxation in several vascular beds. Ang II also activates several cytokines that are important in the genesis of vascular inflammation and hypertrophy. In this context, Ang-(1-7) seems to ...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - October 27, 2014 Category: Surgery Authors: Pernomian L, Pernomian L, Baraldi Araújo Restini C Tags: Vasa Source Type: research