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Condition: Chronic Pain
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Total 3281 results found since Jan 2013.
Patterns Of Multisite Pain And Their Impact On Focal Lower-Extremity Neuromodulation In Individuals With Fibromyalgia: Analysis Of A Real-World Data Registry Using Machine Learning Methods
This study evaluated the distribution of multisite pain in fibromyalgia and its impact on focal lower-extremity neuromodulation. The first objective was to determine if multisite pain maps onto distinct anatomic patterns or should be classified simply by the number of sites. The second objective was to evaluate if multisite pain characteristics are associated with treatment outcomes. Cross-sectional and longitudinal data from a real-world chronic pain registry linked to a wearable, lower-extremity TENS device was analyzed.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Shai Gozani, Xuan Kong Source Type: research
Fibromyalgia or Chronic Fatigue Educational Preferences: In-person vs Virtual
This study assessed if patients preferred in-person or virtual educational sessions for their treatment program during the COVID pandemic. We hypothesized a relatively even split as to the preference of in-person or virtual sessions. The FCFC, operational since 1999, consists of in-depth educational sessions, led by RN staff.
Source: Pain Management Nursing - April 1, 2023 Category: Nursing Authors: Connie Luedtke, Mary Volcheck, Shirley Johnson Source Type: research
Temporal Summation In Patients With Fibromyalgia And Long-Term Opioid Use
In chronic pain conditions, including fibromyalgia, pain amplification within the central nervous system, or "central sensitization ”, contributes to the development and maintenance of chronic pain. Yet, the potential contribution of opioid medications to central sensitization is unknown. As a measure of central sensitization in patients, temporal summation involves the application of repeated noxious stimuli and the recording of participants' pain ratings to each stimulus. To clarify how long-term opioid use may influence central sensitization in chronic pain patients, we measured temporal summation among participants w...
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Jason Dee Bao, Morgan Rosser, Su Hyoun Park, Anne K. Baker, Katherine Martucci Source Type: research
Favorite Music'S Modulation Of Pressure Pain And Temporal Summation Of Pain Among Patients With Fibromyalgia
Music has gained attention as an alternative therapy to reduce pain. We previously reported favorite music was superior to white noise in decreasing pain sensitivity among healthy volunteers, measured as higher pressure pain threshold (PPTh) and tolerance (PPTol). This initial evidence prompted interest in investigating this effect in patients with chronic pain. The current pilot project evaluated how pain processing differed when listening to self-selected favorite music compared to white noise among participants with Fibromyalgia.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Carin Colebaugh, Jenna Wilson, Kelsey Flowers, Angelina R. Franqueiro, Jingui He, Robert R. Edwards, Peter R. Chai, Kristin L. Schreiber Source Type: research
A Pilot Study Of The Correlation Between Resilience And Pain In Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition of childhood which frequently presents with joint pain. In some patients, pain persists even when disease activity is well controlled (Tesher, 2021). Few risk factors for chronic pain in childhood arthritis have been identified. However, low resilience is associated with increased pain in juvenile fibromyalgia (Gmuca, 2019). Low psychological resilience has never been evaluated as a potential risk factor for chronic pain in JIA.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Daniella Schocken, Susmita Kashikar-Zuck, Tracy V. Ting Source Type: research
Establishing A Minimally Clinically Important Difference Of Movement-Evoked Pain In Musculoskeletal Pain
Movement-evoked pain (MEP) is a common complaint of patients with musculoskeletal pain and is considered distinct from resting pain. There is growing interest in measuring MEP as a primary outcome in clinical trials, but no minimally clinically important difference (MCID) has been established, limiting interpretations. We analyzed data from 310 participants who participated in previous clinical trials (65 with chronic Achilles tendinopathy: NCT04059146; 245 with fibromyalgia: NCT01888640) to establish an MCID for MEP.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Timothy R. Fleagle, Andrew A. Post, Dana L. Dailey, Carol GT Vance, Emine O. Bayman, Leslie J. Crofford, Kathleen A. Sluka, Ruth L. Chimenti Source Type: research
Pilot Study Of Lower Extremity Coordination Patterns, Pain, And Fatigue During The Six-Minute Walk Test In Juvenile Fibromyalgia
Juvenile-onset fibromyalgia (JFM) is a chronic condition characterized by widespread musculoskeletal pain. For adolescents with fibromyalgia, existing treatments can provide acute pain relief but rarely result in long-term pain resolution. Long-term pain contributes to a reduction in physical activity that can propagate to dysfunctional motor behavior and further deconditioning. The six-minute walk test (6MWT) is commonly used to evaluate functional ability in JFM; however, the most frequently used outcome measure —total distance traversed—is unable to provide spatiotemporal characterizations of motor behavior (i.e., c...
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Scott Bonnette, Robert C. Gibler, Christopher A. DiCesare, Gregory D. Myer, Susmita Kashikar-Zuck Source Type: research
Movement-Evoked And Resting Pain Are Each Associated With Disease Impact In Individuals With Fibromyalgia
Fibromyalgia (FM) is characterized by widespread chronic pain and tenderness and is estimated to affect 2% of the general population. Non-pharmacological interventions including exercise are recommended as a first-line treatment for FM, however, movement-evoked pain often limits individuals' ability to participate in physical activity. The assessment of movement-evoked pain, in addition to resting pain, may enhance the individualization of clinical evaluation through inclusion of patient-specific tasks for those with widespread pain conditions.
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Andrew A. Post, David-Erick Lafontant, Megan E. McCabe, Emine O. Bayman, Dana L. Dailey, Ruth L. Chimenti, Michele Costigan, Carla Franck, Trevis Huff, Elizabeth Johnson, Maxine Koepp, Tina Neill-Hudson, Carol GT Vance, Barbara Van Gorp, Bridget M. Zimmer Tags: Pain, Movement, & Rehabilitation Science Source Type: research
Neural Correlates Of Altered Reward-Driven Attention In Chronic Pain And Opioid Use
In this study, we focused on the representation of attentional processing in the brain while participants anticipated a monetary reward. Using functional magnetic resonance imaging (fMRI) combined with a well-established monetary incentive delay task, we collected data across three groups: healthy controls (N=35), patients with fibromyalgia who were not taking opioids (non-opioid FM; N=36), and patients with fibromyalgia who were taking opioids long-term (i.e., greater than 90 days opioid use, opioid FM; N=26).
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Su Hyoun Park, Anne Baker, Katherine T. Martucci Source Type: research
Cognitive Behavioral Therapy Relieves Fibromyalgia Pain And Modulates Pain Catastrophizing Specific Brain Circuitry
Fibromyalgia (FM) is a chronic, common pain disorder characterized by widespread, pervasive pain-related symptomatology and high levels of negative affect. Cognitive-behavioral therapy (CBT) may foster improvement in FM symptoms via reductions in pain-related catastrophizing (a negative, pain-amplifying cognitive/emotional process). In this randomized controlled trial, we investigated the effect of CBT on clinical improvement and catastrophizing-specific brain circuitry. Adult women with FM were randomized to one of the two 8-week interventions: CBT (N=64) or education control (EDU, N=34) (ratio=2:1).
Source: The Journal of Pain - April 1, 2023 Category: Materials Science Authors: Jeungchan Lee, Asimina Lazaridou, Myrella Paschali, Marco Loggia, Dan-Mikael Ellingsen, Alessandra Anzolin, Arvina Grahl, Ajay D. Wasan, Vitaly Napadow, Robert R. Edwards Source Type: research
The immunomodulatory effects of ethosuximide and sodium butyrate on experimentally induced fibromyalgia: The interaction between IL-4, synaptophysin, and TGF- β1/NF-κB signaling
Int Immunopharmacol. 2023 Mar 27;118:110061. doi: 10.1016/j.intimp.2023.110061. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Fibromyalgia is a widespread chronic pain syndrome associated with several comorbid conditions that affect the quality of patients' life. Its pathogenesis is complex, and the treatment strategies are limited by partial efficacy and potential adverse effects. So, our aim was to investigate the possible ameliorative effects of ethosuximide and sodium butyrate on fibromyalgia and compare their effects to pregabalin.MATERIALS AND METHODS: In a mouse model of reserpine induced fibromyalgia, the effe...
Source: International Immunopharmacology - March 29, 2023 Category: Allergy & Immunology Authors: Maaly A Abd Elmaaboud Marwa M Awad Rehab A A El-Shaer Ahmed M Kabel Source Type: research
Central Pain Sensitization in Patients with Chronic Plaque Psoriasis
ConclusionsCentral sensitization may be associated with psoriasis, particularly in those with high PASI, concomitant PsA, anxiety, depression, and severe quality of life impairment.
Source: Dermatology and Therapy - March 29, 2023 Category: Dermatology Source Type: research
Use of pain-related gene features to predict depression by support vector machine model in patients with fibromyalgia
This study developed a support vector machine model combined with principal component analysis to differentiate major depression in fibromyalgia syndrome patients using a microarray dataset, including 25 fibromyalgia syndrome patients with major depression, and 36 patients without major depression. Gene co-expression analysis was used to select gene features to construct support vector machine model. The principal component analysis can help reduce the number of data dimensions without much loss of information, and identify patterns in data easily. The 61 samples available in the database were not enough for learning based...
Source: Frontiers in Genetics - March 29, 2023 Category: Genetics & Stem Cells Source Type: research
Central Pain Sensitization in Patients with Chronic Plaque Psoriasis
ConclusionsCentral sensitization may be associated with psoriasis, particularly in those with high PASI, concomitant PsA, anxiety, depression, and severe quality of life impairment.
Source: Dermatology and Therapy - March 29, 2023 Category: Dermatology Source Type: research
