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Condition: Chronic Pain

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Total 3281 results found since Jan 2013.

Acupoint Catgut Embedding Diminishes Fibromyalgia Pain through TRPV1 in the Mouse Brain
CONCLUSIONS: These novel findings suggest that chronic FM pain can be modulated by ACE or TRPV1 gene deletion. The analgesic effect of ACE through the TRPV1 pathway may reflect its potential as a therapeutic target for FM treatment.PMID:37519181 | DOI:10.31083/j.jin2204097
Source: Journal of Integrative Neuroscience - July 31, 2023 Category: Neuroscience Authors: Po-Chih Lai Chia-Ming Yen I-Han Hsiao Yung-Hsiang Chen Yi-Wen Lin Source Type: research

The Utilization of Low Dose Naltrexone for Chronic Pain
AbstractNaltrexone is a mu-opioid receptor antagonist with a long half-life compared with naloxone. Both of these drugs, along with others, were developed with the intention of reversing the effects of opioid abuse or toxicity. Evidence has also shown that naltrexone has a benefit in preventing relapse by reducing opioid cravings and reducing symptoms of opioid withdrawal. The benefits of this drug were not only shown with opioid abuse. In 1984 this drug was also approved for alcohol abuse. Naltrexone has been proven to decrease alcohol relapse by decreasing the craving. Apart from these approved indications for the use of...
Source: CNS Drugs - July 28, 2023 Category: Neurology Source Type: research

Personality construct as a biomarker in fibromyalgia: A narrative review from an autonomic rehabilitation perspective
CONCLUSIONS: This article lays out a constructive framework for individualized and personalized medicine for the effective rehabilitation of FM patients. The quest to find a definitive diagnosis of FM should include personality biomarkers that might translate into personalized medicine. An individualistic approach may bank upon artificial intelligence algorithms for both diagnostic as well as prognostic purposes in FM.PMID:37482976 | DOI:10.3233/BMR-220353
Source: Journal of Back and Musculoskeletal Rehabilitation - July 24, 2023 Category: Orthopaedics Authors: Poorvi Kulshreshtha Kishore Kumar Deepak Source Type: research