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Condition: Stroke

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Total 73147 results found since Jan 2013.

Sex differences in the prevalence and clinical outcomes of subclinical peripheral artery disease in the Health, Aging, and Body Composition (Health ABC) study.
The objective of the study was to determine if there are sex-based differences in the prevalence and clinical outcomes of subclinical peripheral artery disease (PAD). We evaluated the sex-specific associations of ankle-brachial index (ABI) with clinical cardiovascular disease outcomes in 2797 participants without prevalent clinical PAD and with a baseline ABI measurement in the Health, Aging, and Body Composition study. The mean age was 74 years, 40% were black, and 52% were women. Median follow-up was 9.37 years. Women had a similar prevalence of ABI < 0.9 (12% women versus 11% men; P = 0.44), but a higher prevalence o...
Source: Vascular - March 19, 2013 Category: Surgery Authors: Hiramoto JS, Katz R, Ix JH, Wassel C, Rodondi N, Windham BG, Harris T, Koster A, Satterfield S, Newman A, Shlipak MG, for the Health ABC study Tags: Vascular Source Type: research

Utility of internal jugular vein reconstruction in modified radical neck dissection.
Abstract The benefits to modified radical neck dissection (MRND) are established but the procedure involves substantial neck dissection with occasional resection of the internal jugular vein (IJV). Loss of the IJV is associated with morbidity including increased cerebral edema, stroke, laryngeal edema, blindness, facial fullness, and dural thrombosis. This paper discusses the morbidity associated with MRND, especially regarding venous outflow concerns and technical approaches to IJV reconstruction. Patients who have previously undergone MRND may benefit from immediate reconstruction and/or reanastomosis of the IJV...
Source: Vascular - March 19, 2013 Category: Surgery Authors: Dua A, Desai SS Tags: Vascular Source Type: research

Urgent carotid endarterectomy in patients with acute neurological ischemic events within six hours after symptoms onset.
In conclusion, based on our results urgent CEA is a safe and effective treatment option for patients with crescendo TIA and stroke in progression with acceptable rate of postoperative complications. PMID: 23508394 [PubMed - as supplied by publisher]
Source: Vascular - March 18, 2013 Category: Surgery Authors: Gajin P, Radak D, Tanaskovic S, Babic S, Nenezic D Tags: Vascular Source Type: research

Single-stage thoracic and abdominal endovascular aneurysm repair for multilevel aortic disease.
In conclusion, single-stage TEVAR and EVAR procedures for multilevel aortic disease were found to be safe and feasible modalities for high-risk patients. PMID: 23508387 [PubMed - as supplied by publisher]
Source: Vascular - March 18, 2013 Category: Surgery Authors: Samura M, Zempo N, Ikeda Y, Hidaka M, Kaneda Y, Suzuki K, Tsuboi H, Hamano K Tags: Vascular Source Type: research

Carotid endarterectomy in the elderly: risk factors, intraoperative carotid hemodynamics and short-term complications: a UK tertiary center retrospective analysis.
Abstract This retrospective analysis aims to demonstrate the safety of carotid endarterectomy (CE) in patients >75 years with particular attention paid to intraoperative hemodynamics. Four hundred and ninety-six consecutive patients with >70% symptomatic and asymptomatic stenosis who underwent CE were prospectively assessed and divided into those <75 years (n = 408; mean 64 years) and those >75 years (n = 88; mean 78 years). Associated risk factors, hemodynamic parameters, surgical techniques and 30-day perioperative complications were compared. Carotid artery stump pressures of <25 mmHg (13 versus ...
Source: Vascular - March 18, 2013 Category: Surgery Authors: Sadideen H, Thomson DR, Lewis RR, Padayachee TS, Taylor PR Tags: Vascular Source Type: research

Animal models of atherosclerosis and magnetic resonance imaging for monitoring plaque progression.
Abstract Atherosclerosis, the main cause of heart attack and stroke, is the leading cause of death in most modern countries. Preventing clinical events depends on a better understanding of the mechanism of atherosclerotic plaque destabilization. Our knowledge on the characteristics of vulnerable plaques in humans has grown past decades. Histological studies have provided a precise definition of high-risk lesions and novel imaging methods for human atherosclerotic plaque characterization have made significant progress. However the pathological mechanisms leading from stable lesions to the formation of vulnerable pl...
Source: Vascular - March 14, 2013 Category: Surgery Authors: Millon A, Canet-Soulas E, Boussel L, Fayad Z, Douek P Tags: Vascular Source Type: research

Nox2-Derived Superoxide Contributes to Cerebral Vascular Dysfunction in Diet-Induced Obesity Basic Sciences
Conclusions— Endothelial dysfunction produced by a HFD occurs in a temporal manner and appears much earlier in cerebral arterioles than in carotid arteries. Genetic studies revealed that Nox2-derived superoxide plays a major role in endothelial dysfunction produced by a HFD. Such functional changes may serve to predispose blood vessels to reduced vasodilator responses and thus may contribute to alterations in cerebral blood flow associated with obesity.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Lynch, C. M., Kinzenbaw, D. A., Chen, X., Zhan, S., Mezzetti, E., Filosa, J., Ergul, A., Faulkner, J. L., Faraci, F. M., Didion, S. P. Tags: Animal models of human disease, Type 2 diabetes, Endothelium/vascular type/nitric oxide, Other Vascular biology Basic Sciences Source Type: research

Peripheral Endothelial Function and Cardiovascular Events in High-Risk Patients Vascular Medicine
Conclusions Advanced endothelial dysfunction significantly correlated with near future cardiovascular events in high-risk patients. This physiological vascular measurement improved risk discrimination when added to the FRS, BNP, and SYNTAXsc. Clinical Trial Registration URL: clinicaltrials.gov (http://www.clinicaltrials.gov). Unique identifier: NCT00737945.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Matsuzawa, Y., Sugiyama, S., Sumida, H., Sugamura, K., Nozaki, T., Ohba, K., Matsubara, J., Kurokawa, H., Fujisue, K., Konishi, M., Akiyama, E., Suzuki, H., Nagayoshi, Y., Yamamuro, M., Sakamoto, K., Iwashita, S., Jinnouchi, H., Taguri, M., Morita, S., Ma Tags: Vascular Medicine Source Type: research

Differential Effect of B-Vitamin Therapy by Antiplatelet Use on Risk of Recurrent Vascular Events After Stroke Brief Reports
Conclusions— High-dose B vitamin therapy may be associated with a higher risk of recurrent stroke among stroke survivors taking antiplatelets, but does not have a significant effect on recurrent stroke risk in those who are not on antiplatelets. Future randomized controlled trials may consider evaluating the effect of homocysteine lowering among stroke survivors with elevated homocysteine who are not on antiplatelet therapy.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Arshi, B., Ovbiagele, B., Markovic, D., Saposnik, G., Towfighi, A. Tags: Secondary prevention, Antiplatelets, Endothelium/vascular type/nitric oxide Brief Reports Source Type: research

Vascular Smooth Muscle Cells Are Responsible for a Prothrombotic Phenotype of Spontaneously Hypertensive Rat Arteries.
CONCLUSIONS: The prothrombotic phenotype of the SHR vessel wall was because of the ability of SMCs to support greater thrombin generation and resulted in accelerated occlusive thrombus formation after arterial injury, which was sensitive to glycoprotein IbĪ±-von Willebrand factor inhibitors. PMID: 25722431 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 26, 2015 Category: Cardiology Authors: Aissa KA, Lagrange J, Mohamadi A, Louis H, Houppert B, Challande P, Wahl D, Lacolley P, Regnault V Tags: Arterioscler Thromb Vasc Biol Source Type: research

Vascular contributions to cognitive impairment
Unlike many neurodegenerative causes of cognitive impairment and dementia, vascular damage is preventable. Despite the heterogeneity of vascular cognitive impairment (VCI) and the complexity of its clinical presentations, the potential for limiting progression and changing the trajectory of damage makes it all the more important for physicians to be educated about the syndrome and to remain vigilant when taking care of patients. In this review, we outline an approach to patients with possible VCI, summarize current treatment and prevention guidelines, and provide an overview with case examples.
Source: Nature Clinical Practice - June 8, 2015 Category: Neurology Authors: Wright, C. B., Flores, A. Tags: All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, Vascular dementia, Assessment of cognitive disorders/dementia Clinical and Ethical Challenges Source Type: research

Faster Surgery for Stroke and TIA Requires More Expedient Referral to the Vascular Service
This study aimed to assess and identify rate-limiting steps to performing CEA.
Source: Journal of Vascular Surgery - July 24, 2015 Category: Surgery Authors: Hong-Yau Tan, Phillip Puckridge, Conor Marron, James Ian Spark Tags: Abstract from the 2015 Annual Meetings of the Western Vascular Society and Australia and New Zealand Society for Vascular Surgery Source Type: research

Perioperative and Long-Term Impact of Chronic Kidney Disease on Carotid Artery Interventions
Chronic kidney disease (CKD) increases morbidity and mortality after vascular procedures and adversely affects late patient survival. Presence of CKD also confers an increased risk of stroke in patients with asymptomatic carotid stenosis. Patients undergoing carotid intervention in the Vascular Study Group of New England database were stratified by CKD status referable to periprocedural and late outcomes.
Source: Journal of Vascular Surgery - September 23, 2015 Category: Surgery Authors: Derek Klarin, Robert Lancaster, Emel Ergul, Daniel Bertges, Phillip Goodney, Mark Conrad, Richard P. Cambria, Virendra Patel Tags: Abstract from the 2015 New England Society for Vascular Surgery Annual Meeting Source Type: research

Eagle Syndrome Presenting After Blunt Trauma: A Case Series
Eagle syndrome is an unusual phenomenon unfamiliar to most vascular surgeons. Patients develop neurologic or vascular manifestations arising from an elongated styloid process and/or an ossified stylohyoid ligament. These symptoms are secondary to irritation or compression of the neurovascular bundle within the carotid sheath. Presentations can vary from cervical pain and a globus sensation to carotid dissection, transient ischemic attacks, and stroke. Here we present a case series of the carotid subtype identified after blunt trauma.
Source: Journal of Vascular Surgery - December 22, 2015 Category: Surgery Authors: Ashley Mann, Chalmers Wood, Robert Carter, Karl Stark, Scott Kujath, Mark Friedell Tags: Abstract from the 2016 Southern Association for Vascular Surgery Annual Meeting Source Type: research

Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis? Clinical Sciences
Conclusions— In children with dissection and transient cerebral arteriopathy, cerebral arteries demonstrate increased tortuosity. Quantified arterial tortuosity may represent a clinically relevant imaging biomarker of vascular biology in pediatric stroke.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Wei, F., Diedrich, K. T., Fullerton, H. J., deVeber, G., Wintermark, M., Hodge, J., Kirton, A., the Vascular Effects of Infection in Pediatric Stroke (VIPS) Investigators, Dowling, Benedict, Bernard, Fox, Friedman, Lo, Ichord, Tan, Mackay, Hernandez, Hump Tags: Risk Factors, Angiography, Magnetic Resonance Imaging (MRI), Ischemic Stroke, Vascular Disease Clinical Sciences Source Type: research