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Condition: Stroke

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Total 73147 results found since Jan 2013.

Cognitive Impairment Evaluated With Vascular Cognitive Impairment Harmonization Standards in a Multicenter Prospective Stroke Cohort in Korea Brief Reports
Conclusions— VCI, evaluated using the Korean VCIHS neuropsychological protocol, is substantial at 3 months after ischemic stroke in Korea. The use of the 60-minute Korean VCIHS neuropsychological protocol was feasible in large-scale multicenter studies.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Yu, K.-H., Cho, S.-J., Oh, M. S., Jung, S., Lee, J.-H., Shin, J.-H., Koh, I.-S., Cha, J.-K., Park, J.-M., Bae, H.-J., Kang, Y., Lee, B.-C., for the Korean-Vascular Cognitive Impairment Harmonization Standards Study Group Tags: Health policy and outcome research, Behavioral/psychosocial - stroke, Behavioral Changes and Stroke Brief Reports Source Type: research

Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization
Vascular bypass procedures in the central nervous system (CNS) remain technically challenging, hindered by complications and often failing to prevent adverse outcome such as stroke. Thus, there is an unmet clinical need for a safe and effective CNS revascularization. Vascular endothelial growth factors (VEGFs) are promising candidates for revascularization; however, their effects appear to be tissue-specific and their potential in the CNS has not been fully explored. To test growth factors for angiogenesis in the CNS, we characterized the effects of endothelium-specific growth factors on the brain vasculature and parenchym...
Source: Blood - August 1, 2013 Category: Hematology Authors: Gaal, E. I., Tammela, T., Anisimov, A., Marbacher, S., Honkanen, P., Zarkada, G., Leppanen, V.-M., Tatlisumak, T., Hernesniemi, J., Niemela, M., Alitalo, K. Tags: Vascular Biology, Gene Therapy Source Type: research

Gender-specific 30-day outcomes after carotid endarterectomy and carotid artery stenting in the Society for Vascular Surgery Vascular Registry
Objective: Although the optimal treatment of carotid stenosis remains unclear, available data suggest that women have higher risk of adverse events after carotid revascularization. We used data from the Society for Vascular Surgery Vascular Registry to determine the effect of gender on outcomes after carotid endarterectomy (CEA) and carotid artery stenting (CAS).Methods: There were 9865 patients (40.6% women) who underwent CEA (n = 6492) and CAS (n = 3373). The primary end point was a composite of death, stroke, and myocardial infarction at 30 days.Results: There was no difference in age and ethnicity between genders, b...
Source: Journal of Vascular Surgery - November 18, 2013 Category: Surgery Authors: Jeffrey Jim, Ellen D. Dillavou, Gilbert R. Upchurch, Nicholas H. Osborne, Christopher T. Kenwood, Flora S. Siami, Rodney A. White, Joseph J. Ricotta, SVS Outcomes Committee Tags: Clinical research studies Source Type: research

Kinin Receptors in Vascular Biology and Pathology.
Abstract Endogenous kinins are important vasoactive peptides whose effects are mediated by two G-Protein-coupled receptors (R), named B2R (constitutive) and B1R (inducible). They are involved in vascular homeostasis, ischemic pre- and post- conditioning, but also in cardiovascular diseases. They contribute to the therapeutic effects of angiotensin-1 converting enzyme inhibitors (ACEI) and angiotensin AT1 receptor blockers. Benefits derive primarily from vasodilatory, antiproliferative, antihypertrophic, antifibrotic, antithrombic and antioxidant properties, which are associated with the release of endothelial fact...
Source: Current Vascular Pharmacology - February 26, 2014 Category: Drugs & Pharmacology Authors: Couture R, Blaes N, Girolami JP Tags: Curr Vasc Pharmacol Source Type: research

A Personal Sentinel Event: The Nurse's Role in Preventing Vascular Complications
Vascular complications DVT and PE are seen as preventable vascular complications. Keys to preventing these types of complications are ardent assessment and the implementation of appropriate VTE prophylaxis. This presentation will inspire and motivate nurses to assure timely assessments and interventions to prevent vascular complications during hospitalization and after a major trauma. A personal story regarding a traumatic ski accident resulting in multiple bone fractures and subsequent complications including stroke, brain surgery and DVT will be reviewed.
Source: Journal of Vascular Nursing - May 29, 2015 Category: Nursing Authors: Pamela Mahaffrey Tags: 2015 SVN National Conference Presentation Abstract Source Type: research

Childhood Obesity Associates Haemodynamic and Vascular Changes That Result in Increased Central Aortic Pressure with Augmented Incident and Reflected Wave Components, without Changes in Peripheral Amplification.
Authors: Castro JM, García-Espinosa V, Curcio S, Arana M, Chiesa P, Giachetto G, Zócalo Y, Bia D Abstract The aims were to determine if childhood obesity is associated with increased central aortic blood pressure (BP) and to characterize haemodynamic and vascular changes associated with BP changes in obese children and adolescents by means of analyzing changes in cardiac output (stroke volume, SV), arterial stiffness (aortic pulse wave velocity, PWV), peripheral vascular resistances (PVR), and net and relative contributions of reflected waves to the aortic pulse wave amplitude. We included 117 subjects (mean/rang...
Source: International Journal of Vascular Medicine - February 19, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Effects of Vascular and Nonvascular Adverse Events and of Extended-Release Niacin With Laropiprant on Health and Healthcare Costs Original Articles
Conclusions— In HPS2-THRIVE, the addition of extended-release niacin–laropiprant to statin-based therapy reduced quality of life–adjusted survival and increased hospital costs. Clinical Trial Registration— URL: http://clinicaltrials.gov. Unique identifier: NCT00461630.
Source: Circulation: Cardiovascular Quality and Outcomes - July 18, 2016 Category: Cardiology Authors: Kent, S., Haynes, R., Hopewell, J. C., Parish, S., Gray, A., Landray, M. J., Collins, R., Armitage, J., Mihaylova, B., on behalf of the HPS2-THRIVE Collaborative Group Tags: Cardiovascular Disease, Treatment, Cost-Effectiveness, Quality and Outcomes, Vascular Disease Original Articles Source Type: research

Aerobic exercise: A possible therapy for vascular cognitive impairment
Cerebrovascular disease is the second most common cause of cognitive impairment and dementia and contributes to cognitive decline in the neurodegenerative dementias.1 Vascular cognitive impairment (VCI) refers to all forms of mild to severe cognitive impairment associated with cerebrovascular disease. VCI is therefore heterogeneous not only because of the nature of the underlying lesions (associated with stroke or not) but also because of the various brain structures involved (damage to large or small vessels).2 It is also heterogeneous clinically, the term encompassing all cognitive disorders from subtle cognitive impairm...
Source: Neurology - November 13, 2016 Category: Neurology Authors: Foubert-Samier, A., Flicker, L. Tags: All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Vascular dementia, Class I EDITORIALS Source Type: research

Restenosis after carotid artery stenting.
Abstract As a common etiology for ischemic stroke, atherosclerotic carotid stenosis has been targeted by vascular surgery since 1950s. Compared with carotid endarterectomy, carotid angioplasty and stenting (CAS) is almost similarly efficacious and less invasive. These advantages make CAS an alternative in treating carotid stenosis. However, accumulative evidences suggested that the long-term benefit-risk ratio of CAS may be decreased or even neutralized by the complications related to in-stent restenosis (ISR). Therefore, investigating the mechanisms and identifying the influential factors of ISR are of vital impo...
Source: Vascular - January 1, 2017 Category: Surgery Authors: Dai Z, Xu G Tags: Vascular Source Type: research

VESS05. In-Hospital Outcomes of Transcarotid Artery Revascularization and Carotid Endarterectomy in the Society for Vascular Surgery Vascular Quality Initiative
This study compares initial in-hospital outcomes of CEA and TCAR using the Society for Vascular Surgery (SVS) Vascular Quality Initiative TCAR Surveillance Project done in collaboration with the Centers for Medicare and Medicaid Services to create more information for future coverage decisions.
Source: Journal of Vascular Surgery - May 22, 2018 Category: Surgery Authors: Marc L. Schermerhorn, Hanaa Dakour Aridi, Vikram S. Kashyap, Grace J. Wang, Brian Nolan, Jack Cronenwett, Jens Eldrup-Jorgensen, Mahmoud B. Malas Source Type: research

Role of flow-sensitive microRNAs and long noncoding RNAs and in vascular dysfunction and atherosclerosis.
Abstract Atherosclerosis is the primary underlying cause of myocardial infarction, ischemic stroke, and peripheral artery disease. The disease preferentially occurs in arterial regions exposed to disturbed blood flow, in part, by altering expression of flow-sensitive coding- and non-coding genes. In this review, we summarize the role of noncoding RNAs, [microRNAs (miRNAs) and long noncoding RNAs(lncRNAs)], as regulators of gene expression and outline their relationship to the pathogenesis of atherosclerosis. While miRNAs are small noncoding genes that post-transcriptionally regulate gene expression by targeting mR...
Source: Vascular Pharmacology - October 6, 2018 Category: Drugs & Pharmacology Authors: Kumar S, Williams D, Sur S, Wang JY, Jo H Tags: Vascul Pharmacol Source Type: research

Vascular Regeneration in Peripheral Artery Disease.
Abstract Peripheral artery disease is a common disorder and a major cause of morbidity and mortality worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events and at ameliorating symptoms. Medical therapy is effective at reducing the incidence of myocardial infarction and stroke to which these patients are prone but is inadequate in relieving limb-related symptoms, such as intermittent claudication, rest pain, and ischemic ulceration. Limb-related morbidity is best addressed with surgical and endovascular interventions that restore perfusion. Current medical therapies have only mod...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 20, 2020 Category: Cardiology Authors: Cooke JP, Meng S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Society for vascular surgery clinical practice guidelines for management of extracranial cerebrovascular disease
Management of carotid bifurcation stenosis in stroke prevention has been the subject of extensive investigations, including multiple randomized controlled trials. The proper treatment of patients with carotid bifurcation disease is of major interest to vascular surgeons and other vascular specialists. In 2011, the Society for Vascular Surgery published guidelines for treatment of carotid artery disease. At the time, several randomized trials, comparing carotid endarterectomy (CEA) and carotid artery stenting (CAS), were published.
Source: Journal of Vascular Surgery - June 18, 2021 Category: Surgery Authors: Ali F. AbuRahma, Efthymios (Makis) Avgerinos, Robert W. Chang, R. Clement Darling, Audra A. Duncan, Thomas L. Forbes, Mahmoud B. Malas, Mohammad Hassan Murad, Bruce Alan Perler, Richard J. Powell, Caron B. Rockman, Wei Zhou Source Type: research

Bioinspired Approaches to Engineer Antithrombogenic Medical Devices for Vascular Intervention
Arterioscler Thromb Vasc Biol. 2023 Apr 20. doi: 10.1161/ATVBAHA.122.318238. Online ahead of print.ABSTRACTMedical devices form a critical component of health care systems for treating and maintaining patient health. However, devices exposed to blood are prone to blood clotting (thrombosis) and bleeding complications leading to device occlusion, device failure, embolism and stroke, and increased morbidity and mortality. Over the years, developments in innovative material design strategies have been made to help reduce the occurrence of thrombotic events on medical devices, but complications persist. Here, we review materia...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 20, 2023 Category: Cardiology Authors: Jun Ki Hong Anna Waterhouse Source Type: research