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Condition: Stroke

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Total 73147 results found since Jan 2013.

Bioinspired Approaches to Engineer Antithrombogenic Medical Devices for Vascular Intervention
Arterioscler Thromb Vasc Biol. 2023 Apr 20. doi: 10.1161/ATVBAHA.122.318238. Online ahead of print.ABSTRACTMedical devices form a critical component of health care systems for treating and maintaining patient health. However, devices exposed to blood are prone to blood clotting (thrombosis) and bleeding complications leading to device occlusion, device failure, embolism and stroke, and increased morbidity and mortality. Over the years, developments in innovative material design strategies have been made to help reduce the occurrence of thrombotic events on medical devices, but complications persist. Here, we review materia...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 20, 2023 Category: Cardiology Authors: Jun Ki Hong Anna Waterhouse Source Type: research

Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association
The objective of this scientific statement is to evaluate contemporary evidence that either supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol lowering or lipid lowering exerts toxic effects on the brain, leading to cognitive impairment or dementia or hemorrhagic stroke. The writing group used literature reviews, references to published clinical and epidemiology studies, clinical and public health guidelines, authoritative statements, and expert opinion to summarize existing evidence and to identify gaps in current knowledge. Although some retrospective, case control, and prospective lon...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Larry B Goldstein Peter P Toth Jennifer L Dearborn-Tomazos Robert P Giugliano Benjamin J Hirsh Jessica M Pe ña Magdy H Selim Daniel Woo American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Source Type: research

Targets of vascular protection in acute ischemic stroke differ in type 2 diabetes
The objective of the present study was to determine the effects of acute manipulation of potential targets for vascular protection [i.e., NF-B, peroxynitrite, and matrix metalloproteinases (MMPs)] on vascular injury and functional outcome in a diabetic model of cerebral ischemia. Ischemia was induced by middle cerebral artery occlusion in control and type 2 diabetic Goto-Kakizaki rats. Treatment groups received a single dose of the peroxynitrite decomposition catalyst 5,10,15,20-tetrakis(4-sulfonatophenyl)prophyrinato iron (III), the nonspecific NF-B inhibitor curcumin, or the broad-spectrum MMP inhibitor minocycline at re...
Source: AJP: Heart and Circulatory Physiology - March 15, 2013 Category: Cardiology Authors: Kelly-Cobbs, A. I., Prakash, R., Li, W., Pillai, B., Hafez, S., Coucha, M., Johnson, M. H., Ogbi, S. N., Fagan, S. C., Ergul, A. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research

Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells
Conclusion Tyrosine 284 phosphorylation in the ClC-3 channel targeted by Src kinase is an important molecular mechanism for ClC-3 channel activation.
Source: Cardiovascular Research - May 17, 2013 Category: Cardiology Authors: Wang, X.-G., Tao, J., Ma, M.-M., Tang, Y.-B., Zhou, J.-G., Guan, Y.-Y. Tags: Vascular biology Source Type: research

Reduction of iron stores and clinical outcomes in peripheral arterial disease: outcome comparisons in smokers and non-smokers.
Abstract A prospective randomized trial suggested that iron (ferritin) reduction improved outcomes in smokers. The present study reanalyzed the trial results in smokers compared with non-smokers. Randomization of 1262 men with peripheral arterial disease (540 smokers and 722 non-smokers) to iron reduction (phlebotomy) or control groups permitted analysis of the effects of iron reduction and smoking on primary (all-cause mortality) and secondary (death plus non-fatal myocardial infarction or stroke) endpoints. Iron reduction resulted in significant improvement in the primary (hazard ratio [HR] 0.661, 95% confidence...
Source: Vascular - March 21, 2013 Category: Surgery Authors: Depalma RG, Zacharski LR, Chow BK, Shamayeva G, Hayes VW Tags: Vascular Source Type: research

Compliance and echographic carotid plaque evolution in patients with acute ischemic stroke treated with atorvastatin according to usual care.
In conclusion, an irregular compliance has been seen in patients with acute ischemic stroke treated with atorvastatin according to usual care. Nearly one-third of our patients stopped the treatment before the course of a year. The effect on lipids and its pleiotropic effect on atheromatous carotid artery disease might support the long-term use of atorvastatin, regardless of the dose, in patients with acute ischemic stroke. PMID: 23518842 [PubMed - as supplied by publisher]
Source: Vascular - March 21, 2013 Category: Surgery Authors: Delgado MG, Naves M Tags: Vascular Source Type: research

Treatment of proximal vertebral artery disease.
Abstract Vertebral arterial disease (VAD) is a less commonly recognized and treated source of cerebrovascular ischemia compared with carotid artery disease. Patients are often referred for treatment after they have developed symptoms in the form of transient ischemic attacks or had a posterior hemispheric stroke. Traditional treatment of VAD has been surgical. More recently, endovascular treatment of VAD has been utilized. We performed a retrospective review of our institutional experience in treating VAD from 2001 to 2010. For treatment of proximal VAD, perioperative morbidity is lower for the endovascular group ...
Source: Vascular - March 21, 2013 Category: Surgery Authors: Shutze W, Gierman J, McQuade K, Pearl G, Smith B Tags: Vascular Source Type: research