Filtered By:
Condition: Alcoholism

This page shows you your search results in order of relevance. This is page number 13.

Order by Relevance | Date

Total 52912 results found since Jan 2013.

Ligusticum chuanxiong Prevents Ovariectomy-Induced Liver and Vascular Damage in Rats.
Abstract Post-menopause, there is an increase in body weight, visceral adiposity, and risk of developing non-alcoholic fatty liver disease (NAFLD), which leads to various cardiovascular diseases (CVDs). Some natural products have proven useful for counteracting the detrimental effects of menopause. The rhizome of Ligusticum chuanxiong Hort. (LC) is a well-known medicinal herb widely used in Chinese communities for the treatment of CVDs. The hepatic and vascular protective effects of LC ethanolic extract under postmenopausal conditions were investigated on ovariectomized (OVX) rats supplemented with or without LC e...
Source: The American Journal of Chinese Medicine - August 2, 2013 Category: Complementary Medicine Authors: Li CM, Wu JH, Yang RF, Dong XL, He ZY, Tian XL, Guo DJ, Wong MS, Qiu TQ, Chan SW Tags: Am J Chin Med Source Type: research

The relationship between lymphatic vascular density and vascular endothelial growth factor A (VEGF-A) expression with clinical-pathological features and survival in pancreatic adenocarcinomas
Background: Pancreatic cancer is a rare tumor with an extremely low survival rate. Its known risk factors include the chronic use of tobacco and excessive alcohol consumption and the presence of chronic inflammatory diseases, such as pancreatitis and type 2 diabetes. Angiogenesis and lymphangiogenesis, which have been the focus of recent research, are considered prognostic factors for cancer development. Knowing the angiogenic and lymphangiogenic profiles of a tumor may provide new insights for designing treatments according to the different properties of the tumor. The aim of this study was to evaluate the density of bloo...
Source: Diagnostic Pathology - October 18, 2013 Category: Pathology Authors: Verônica ZorgettoGiórgia SilveiraJoão Paulo Oliveira-CostaDanilo SoaveFernando SoaresAlfredo Ribeiro-Silva Source Type: research

The current situation on vascular cognitive impairment after ischemic stroke in Changsha
In this study, we determined that the prevalence of VCI was 41.8%. Aging, paraventricular white matter lesion (WML), macroangiopathy, high levels of alcohol, a lack of hobbies, and excessive sleep were risk factors for vascular cognitive impairment no dementia (VCIND). A high level of education, manual-work, low level of alcohol use, regular health checks, a vegetable-based diet, and more fruit and milk were protective factors for VCIND. Living alone, hyperlipidemia, transient ischemic attack, a family history of stroke, and brain atrophy were risk factors of vascular dementia (VD). A high educational level, a vegetable-ba...
Source: Archives of Gerontology and Geriatrics - October 22, 2013 Category: Geriatrics Authors: Qiuyun Tu, Binrong Ding, Xia Yang, Song Bai, Junshi Tu, Xiao Liu, Ranran Wang, Jinghua Tao, Hui Jin, Yiqun Wang, Xiangqi Tang Source Type: research

Fabrication of a heparin-PVA complex hydrogel for application as a vascular access.
Abstract A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin-PVA hydrogel conduit and evaluate its potential for vascular access. Heparin-PVA complex hydrogel showed suppressed heparin release and prevented clot formation, depending on the molecular weight of the PVA. Strength of the hydrogel conduit was increased by embedding a Dacron(®) mesh between two PVA layers. The tubular heparin-PVA complex hydrogel displayed a burst pressure of 750 mmHg. The tubula...
Source: Biomed Res - February 27, 2014 Category: Research Authors: Negishi J, Nam K, Kimura T, Hashimoto Y, Funamoto S, Higami T, Fujisato T, Kishida A Tags: J Biomed Mater Res B Appl Biomater Source Type: research

Maternal alcohol consumption in pregnancy enhances arterial stiffness and alters vasodilator function that varies between vascular beds in fetal sheep.
Abstract While the impact of alcohol consumption by pregnant women on fetal neurodevelopment has received much attention, the effects on the cardiovascular system are not well understood. We hypothesised that repeated exposure to alcohol (ethanol) in utero would alter fetal arterial reactivity and wall stiffness, key mechanisms leading to cardiovascular disease in adulthood. Ethanol (0.75g per kg body weight) was infused intravenously into ewes over one hour daily for 39 days in late pregnancy (days 95-133 of pregnancy, term ≈147 days). Maternal and fetal plasma ethanol concentrations at the end of the hour were...
Source: The Journal of Physiology - April 22, 2014 Category: Physiology Authors: Parkington HC, Kenna KR, Sozo FF, Coleman HA, Bocking A, Brien JF, Harding R, Walker DW, Tare M Tags: J Physiol Source Type: research

Valsartan Blocked Alcohol‐Induced, Toll‐Like Receptor 2 Signaling‐Mediated Inflammation in Human Vascular Endothelial Cells
ConclusionsTLR2 signaling‐mediated alcohol induced inflammatory response in human vascular epithelial cells in vitro, which was inhibited by valsartan.
Source: Alcoholism: Clinical and Experimental Research - October 23, 2014 Category: Addiction Authors: Yushu Wang, Yi Li, Qingyu Shen, Xiangpen Li, Juan Lu, Xiangping Li, Deling Yin, Ying Peng Tags: Original Article Source Type: research

Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors.
Abstract The incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing. Despite this is apparently associated with the growing increase in obesity, insulin resistance and obesity-related metabolic disturbances their presence is not a necessary or sufficient condition to explain the accumulation of fat in the liver. Conversely, NAFLD is a predictor of other metabolic risks. NAFLD is currently the most frequent chronic liver disease but should not be considered benign or anecdotic because a considerable proportion of patients with NAFLD progress to cirrhosis and end-stage liver d...
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Camps J, Joven J Tags: World J Gastroenterol Source Type: research

Emerging Vascular Risk Factors in Women: any differences from men?
Abstract Gender differences have been reported for traditional vascular risk factors such as smoking, obesity, diabetes, hypertension, dyslipidemia, age and family history of premature coronary heart disease. The prevalence, severity, associations and response to treatment of several emerging cardiovascular disease (CVD) risk factors may also differ between men and women. Such CVD risk factors include certain inflammatory and hemostatic markers, endothelial dysfunction, homocysteine, lipid disorders, microalbuminuria/proteinuria, coronary artery calcium score, arterial stiffness, periodontitis, inflammatory bowel ...
Source: Current Medicinal Chemistry - September 4, 2015 Category: Chemistry Authors: Katsiki N, Mikhailidis DP Tags: Curr Med Chem Source Type: research

Ethanol Inhibits γ-Secretase Proteolytic Activity in Vascular Smooth Muscle Cells.
CONCLUSIONS: EtOH inhibits Notch signaling in vascular SMCs at the level of γ-secretase activity, possibly by affecting lipid raft function. Such a response might be expected to result in attenuation of pathologic vessel remodeling and thus may contribute to moderate alcohols' cardioprotective effects. PMID: 26443551 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - October 7, 2015 Category: Addiction Authors: Hatch E, Morrow D, Liu W, Cahill PA, Redmond EM Tags: Alcohol Clin Exp Res Source Type: research

Vascular and Chronological Age in Subjects with Erectile Dysfunction: A Cross‐Sectional Study
ConclusionsIn subjects referring for ED without a personal history of CV events, Δage is associated with an adverse cardio‐metabolic profile and worse penile color Doppler ultrasound parameters. Δage provides a simple method for identifying high‐risk men that must undergo significant modification in their lifestyle and risk factors. In addition, it can be considered a simple, inexpensive, and safe surrogate marker of penile arterial damage. Rastrelli G, Corona G, Mannucci E, and Maggi M. Vascular and chronological age in subjects with erectile dysfunction: A cross‐sectional study. J Sex Med **;**:**–**.
Source: The Journal of Sexual Medicine - December 3, 2015 Category: Sexual Medicine Authors: Giulia Rastrelli, Giovanni Corona, Edoardo Mannucci, Mario Maggi Tags: Original Research Source Type: research

Association of Genetic Polymorphisms on Vascular Endothelial Growth Factor and its Receptor Genes with Susceptibility to Coronary Heart Disease.
CONCLUSIONS Genetic polymorphisms on VEGF (rs699947) and KDR (rs2305948and rs1870377), as well as relevant haplotypes, may serve as genetic markers that might be useful in future investigations on the pathogenesis of CHD. PMID: 26726843 [PubMed - in process]
Source: Medical Science Monitor - January 13, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Long term performance evaluation of small-diameter vascular grafts based on polyvinyl alcohol hydrogel and dextran and MSCs-based therapies using the ovine pre-clinical animal model
In conclusion, PVA/Dx graft can be an excellent scaffold candidate for vascular reconstruction, including clinic mechanically challenging applications, such as SDVGs, especially when associated to MSCs-based therapies to promote higher endothelialization and lower fibrosis of the vascular prosthesis, but also higher PR values. Graphical abstract
Source: International Journal of Pharmaceutics - September 19, 2016 Category: Drugs & Pharmacology Source Type: research

International patent applications for non ‐injectable naloxone for opioid overdose reversal: Exploratory search and retrieve analysis of the PatentScope database
Conclusion. We find consistent direction of development of intranasal sprays to high‐concentration, low‐volume formulations with bioavailability in the 20–60% range. These have potential to deliver a therapeutic dose in 0.1 mL volume. [McDonald R, Danielsson Glende Ø, Dale O, Strang J. International patent applications for non‐injectable naloxone for opioid overdose reversal: Exploratory search and retrieve analysis of the PatentScope database. Drug Alcohol Rev 2017;00:000‐000]
Source: Drug and Alcohol Review - June 8, 2017 Category: Addiction Authors: Rebecca McDonald, Øyvind Danielsson Glende, Ola Dale, John Strang Tags: Comprehensive Review Source Type: research

Statin therapy exacerbates alcohol-induced constriction of cerebral arteries via modulation of ethanol-induced BK channel inhibition in vascular smooth muscle.
Abstract Statins constitute the most commonly prescribed drugs to decrease cholesterol (CLR). CLR is an important modulator of alcohol-induced cerebral artery constriction (AICAC). Using rats on a high CLR diet (2% CLR) we set to determine whether atorvastatin administration (10 mg/kg daily for 18-23 weeks) modified AICAC. Middle cerebral arteries were pressurized in vitro at 60 mmHg and AICAC was evoked by 50 mM ethanol, that is, equivalent to blood alcohol detected in humans following moderate-to-heavy drinking. AICAC was evident in high CLR+atorvastatin group but not in high CLR diet+placebo. Statin exacerbatio...
Source: Biochemical Pharmacology - August 30, 2017 Category: Drugs & Pharmacology Authors: Simakova MN, Bisen S, Dopico AM, Bukiya AN Tags: Biochem Pharmacol Source Type: research

Ent-kaurane diterpenoids from the pericarps of Datura metel L. acted on the vascular endothelial cells via TRPC6 and NF- κB protein
AbstractTwo new ent-kaurane diterpenoid glycosides, namely kaurane acid glycosides B –C (1 –2), together with three known compounds, 16β,17-dihydroxy-ent-kauran-19-oic acid (3), paniculoside-IV (4), and kaurane acid glycoside A (5), were isolated from then-butyl alcohol-soluble fractions of ethanol extracts of dried pericarps ofDatura metel L. Compounds3–5 were isolated from Solanaceae for the first time. The structures of these compounds were identified by the analyses of spectroscopic data. All isolates were screened for their bioactivities by acting on the vascular endothelial cells. It was determined that compou...
Source: Medicinal Chemistry Research - September 5, 2017 Category: Chemistry Source Type: research