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Effects of Cerebral Ischemia on Levels of Vascular Endothelial Growth Factor (VEGF) and its Soluble Receptors: A Possible Link to Angiogenesis in Arteriovenous Malformations
CONCLUSION: Decreased levels of sVEGFR1 can be a mechanism contributing to angiogenesis in AVMs by increasing the levels of VEGF available to bind membrane-bound VEGFRs.PMID:34169992 | DOI:10.5137/1019-5149.JTN.32714-20.2
Source: Turkish Neurosurgery - June 25, 2021 Category: Neurosurgery Authors: Birol Bayraktar Dursun Turkoz Aytac Turkoz Ahmet Karkucak Source Type: research
Ventilatory efficiency in pulmonary vascular diseases
Eur Respir Rev. 2021 Jul 20;30(161):200214. doi: 10.1183/16000617.0214-2020. Print 2021 Sep 30.ABSTRACTCardiopulmonary exercise testing (CPET) is a frequently used tool in the differential diagnosis of dyspnoea. Ventilatory inefficiency, defined as high minute ventilation (V' E) relative to carbon dioxide output (V' CO2 ), is a hallmark characteristic of pulmonary vascular diseases, which contributes to exercise intolerance and disability in these patients. The mechanisms of ventilatory inefficiency are multiple and include high physiologic dead space, abnormal chemosensitivity and an altered carbon dioxide (CO2) set-point...
Source: Respiratory Care - July 22, 2021 Category: Respiratory Medicine Authors: Jason Weatherald Brianne Philipenko David Montani Pierantonio Laveneziana Source Type: research
MicroRNA let-7f alleviates vascular endothelial cell dysfunction via targeting HMGA2 under oxygen-glucose deprivation and reoxygenation
In conclusion, let-7f alleviates vascular endothelial cell dysfunction by downregulating HMGA2 expression under OGD/R.PMID:34529965 | DOI:10.1016/j.brainres.2021.147662
Source: Brain Research - September 16, 2021 Category: Neurology Authors: Zhongyan Zhao Chanji Wu Xiangying He Eryi Zhao Shijun Hu Yeguang Han Ting Wang Yanquan Chen Tao Liu Shixiong Huang Source Type: research
Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets
DISCUSSION: In addition to hypertension, microalbuminuria, arterial stiffness, vascular reactivity and cerebrovascular resistance could be potential treatment targets to halt the development or progression of cerebral SVD.PMID:34550097 | DOI:10.18632/aging.203557
Source: Aging - September 22, 2021 Category: Biomedical Science Authors: Salim Elyas Damilola Adingupu Kunihiko Aizawa Francesco Casanova Kim Gooding Jonathan Fulford Dave Mawson Phillip E Gates Angela C Shore David Strain Source Type: research
Retinal Vascular Recovery revealed by retinal imaging following neonatal hypoxia ischemia in mice: is there a role for tyrosine kinase receptor modulation?
CONCLUSION: Retinal artery vasodilation and collateral vessel formation due to HI were rescued by 7,8-DHF treatment. Retinal and collateral vessel monitoring could be diagnostic biomarkers for HI severity. Studies to elucidate mechanisms of 7,8-DHF action on retinal vessels could aid development of therapies for neonatal HI.FUNDING: The study was made possible by the Department of Pediatrics, University of Wisconsin, Madison (OJM, PC), Retina Research Foundation Edwin and Dorothy Gamewell Professorship Award (OJM), NIH/NEI K08 EY032203-01 (OJM, NIH/NINDS K08 NS088563 (PC), NIH Waisman Core Grant P50HD105353 (PC), NIH/NINDS...
Source: Brain Research - September 18, 2022 Category: Neurology Authors: Dila Zafer Thao Adams Ellie Olson Lauren Stenman Onur Taparli Jens Eickhoff Pelin Cengiz Olachi Mezu-Ndubuisi Source Type: research
RNA-binding proteins in vascular inflammation and atherosclerosis
Atherosclerosis. 2023 Jan 17:S0021-9150(23)00009-6. doi: 10.1016/j.atherosclerosis.2023.01.008. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability worldwide, even when patients with an established manifestation of atherosclerotic heart disease are optimally treated according to the clinical guidelines. Apart from the epigenetic control of transcription of the genetic information to messenger RNAs (mRNAs), gene expression is tightly controlled at the post-transcriptional level before the initiation of translation. Although mRNAs are traditio...
Source: Atherosclerosis - February 9, 2023 Category: Cardiology Authors: Marco Sachse Simon Tual-Chalot Giorgia Ciliberti Michael Amponsah-Offeh Kimon Stamatelopoulos Aikaterini Gatsiou Konstantinos Stellos Source Type: research
