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Exercise testing as a screening measure for ability to walk with aprosthesis after transfemoral amputation due to peripheral vascular disease.
Conclusions: At the level of 30 W, the oxygen uptake during the exercise was the closest to the 6 MWT, so we estimated that to be the minimum required level for walking using a prosthesis after transfemoral amputation due to PVD. Implications for Rehabilitation Exercise testing after transfemoral amputation. Walking with a prosthesis causes notable strain to the person's vascular system: after the 6-min walk test, the participants' heart rate reached 75% of the maximum predicted heart rate on average. The study shows that persons after transfemoral amputation due to peripheral vascular disease who reach the level of 30...
Source: Disability and Rehabilitation - September 10, 2013 Category: Rehabilitation Authors: Erjavec T, Vidmar G, Burger H Tags: Disabil Rehabil Source Type: research

Age-Related Vascular Differences Among Patients Suffering from Multiple Sclerosis.
Abstract The aim of our study was to analyze morphological and functional aspects of cerebral veins by mean of eco-color-Doppler in young (i.e., ≤30 years old) and older (i.e., >30 years old) patients suffering from multiple sclerosis. 552 multiple sclerosis patients were evaluated by mean of a dedicated Echo-Color-Doppler support (MyLab Vinco echo-color Doppler System, Esaote), in both supine and sitting positions. 458 (83%) showed alterations in their morphological and functional structures of cerebral veins and were divided in two different groups: 1) ≤30 (110 patients) and 2) >30 years old (348 patie...
Source: Current Neurovascular Research - November 24, 2013 Category: Neurology Authors: Ciciarello F, Mandolesi S, Galeandro AI, Marceca A, Rossi M, Fedele F, Gesualdo M, Cortese F, Zito A, Federico F, Livrea P, Trojano M, Scicchitano P, Ciccone MM Tags: Curr Neurovasc Res Source Type: research

A search strategy to identify studies on the prognosis of work disability: a diagnostic test framework
Conclusions The Work Disability Prognosis filter will help practitioners and researchers who want to find prognostic evidence in the area of work disability evaluation. However, further refining of this filter is possible and needed, especially for the practitioner for whom efficiency is especially important.
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Kok, R., Verbeek, J. A. H. M., Faber, B., van Dijk, F. J. H., Hoving, J. L. Tags: Open access, Epidemiology, Evidence based practice, Occupational and environmental medicine, Public health Research Source Type: research

Project SEARCH UK – Evaluating Its Employment Outcomes
ConclusionProject SEARCH UK represents a valuable addition to the supported employment provision in the UK. Its unique model should inform discussions around best practice in supported employment. Implications for other supported employment programmes are discussed.
Source: Journal of Applied Research in Intellectual Disabilities - September 1, 2015 Category: Disability Authors: Axel Kaehne Tags: Original Article Source Type: research

A Solution in Search of a Problem
Last week, Georgia Governor Nathan Deal’s Education Reform Commission released its draft recommendations for improving and expanding the state’s school choice programs. While some of the commission’s proposed changes are meritorious, the commission failed to recommend expanding the state’s highly popular, nearly universal scholarship tax credit (STC), instead proposing that the state create a new STC that is highly regulated and much more limited in scope. The commission’s two proposed changes to the existing STC (having the Department of Revenue count actual contributions against the tax credit cap rather than m...
Source: Cato-at-liberty - September 25, 2015 Category: American Health Authors: Jason Bedrick Source Type: blogs

Long-Term Benefits of Senolytic Drugs on Vascular Health
This study, however, looked at the structural and functional impacts of cell clearance using a unique combination of drugs on blood vessels over time. Mice were 24 months old when the drugs - a cocktail of dasatinib and quercetin - were administered orally over a three-month period following those initial two years. A separate set of mice with high cholesterol was allowed to develop atherosclerotic plaques for 4 months and were then treated with the drug cocktail for two months. The research showed that senescent cell clearance in either naturally-aged or atherosclerotic mice alleviated vascular dysfunction. Although it d...
Source: Fight Aging! - February 11, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Protective role of sulphoraphane against vascular complications in diabetes.
Conclusion These findings suggest that blockade of oxidative stress and/or the AGE-RAGE axis by sulphoraphane may be a novel therapeutic strategy for preventing vascular complications in diabetes. PMID: 26841240 [PubMed - as supplied by publisher]
Source: Pharmaceutical Biology - February 16, 2016 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Ideal Cardiovascular Health Metrics Are Associated with Disability Independently of Vascular Conditions
Conclusions CVH metrics were strongly and significantly associated with reduced odds of disability independently of vascular and non-vascular conditions. Poorer CVH may cause subclinical vascular disease resulting in disability.
Source: PLoS One - February 29, 2016 Category: Biomedical Science Authors: Saravana Devulapalli et al. Source Type: research

Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress
Conclusions: Short-term exposure to PM2.5 induces vascular insulin resistance and inflammation triggered by a mechanism involving pulmonary oxidative stress. Suppression of vascular insulin signaling by PM2.5 may accelerate the progression to systemic insulin resistance, especially in the context of diet-induced obesity. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as so...
Source: EHP Research - April 29, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article Source Type: research

Retinal Vascular Changes and Prospective Risk of Disabling Dementia: the Circulatory Risk in Communities Study (CIRCS).
CONCLUSION: Generalized arteriolar narrowing and total number of retinal abnormalities may be useful markers for identifying persons at higher risks of disabling dementia. PMID: 27904027 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - December 3, 2016 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Trends and Outcomes in the Operative Management of Traumatic Vascular Injuries: A Comparison of Open versus Endovascular Approaches.
In conclusion, this large series, the use of endovascular procedures increased over time, and was associated with equivalent outcomes to open approaches, despite their higher usage in older patients, those with chest/abdominal injuries, and those with a higher ISS at presentation. Although these retrospective results are encouraging, further prospective study into the role of endovascular therapies in the treatment of vascular injuries. PMID: 28541861 [PubMed - in process]
Source: The American Surgeon - May 1, 2017 Category: Surgery Authors: Richmond BK, Judhan R, Sherrill W, Yacoub M, AbuRahma AF, Knackstedt K, Chumbe JT, Samanta D, Thompson SN Tags: Am Surg Source Type: research

Repetitive vascular occlusion stimulus (RVOS) versus standard care to prevent muscle wasting in critically ill patients (ROSProx):a study protocol for a pilot randomised controlled trial
DiscussionIf this study demonstrates feasibility, the derived data will be used to inform the design (and sample size) of an appropriately-powered prospective trial to clarify whether RVOS can help preserve muscle mass/improve vascular function in critically ill patients.Trial registrationISRCTN Registry,ISRCTN44340629. Registered on 26 October 2017.
Source: Trials - July 23, 2019 Category: Research Source Type: clinical trials

Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis.
This study was designed to expand CHIMERA's capacity to induce more severe injuries, including vascular damage and grey matter gliosis. This was made possible by designing a physical interface positioned between the piston and animal's head to allow higher impact energies to be transmitted to the head without causing skull fracture. Here, we assessed interface-assisted single CHIMERA TBI at 2.5 joules in wild-type mice using a study design that spanned 6 h-60 d time points. Injured animals displayed robust acute neurological deficits, elevated plasma total tau and neurofilament-light levels, transiently increased proin...
Source: Experimental Neurology - November 13, 2019 Category: Neurology Authors: Bashir A, Abebe ZA, McInnes KA, Button EB, Tatarnikov I, Cheng WH, Haber M, Wilkinson A, Barron C, Diaz-Arrastia R, Stukas S, Cripton PA, Wellington CL Tags: Exp Neurol Source Type: research

Adults with Loeys-Dietz syndrome and vascular Ehlers-Danlos syndrome: a cross-sectional study of patient experiences with physical activity.
CONCLUSION: Many adults with Loeys-Dietz- or vascular Ehlers-Danlos syndrome may have a potential to reach more favorable physical activity levels by increasing the frequency and duration of activities. Future directions should include evaluation of effects of professional-led practical and safe physical activity sessions as well as customized multidisciplinary rehabilitation programs for these patient groups. PMID: 32915071 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation - September 10, 2020 Category: Rehabilitation Authors: Johansen H, Velvin G, Lidal I Tags: Disabil Rehabil Source Type: research

Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships
AbstractVascular comorbidities have a deleterious impact on multiple sclerosis clinical outcomes but it is unclear whether this is mediated by an excess of extracranial vascular disease (i.e. atherosclerosis) and/or of cerebral small vessel disease or worse multiple sclerosis pathology. To address these questions, a study using a unique post-mortem cohort wherein whole body autopsy reports and brain tissue were available for interrogation was established. Whole body autopsy reports were used to develop a global score of systemic vascular disease that included aorta and coronary artery atheroma, cardiac hypertensive disease...
Source: Brain - September 2, 2020 Category: Neurology Source Type: research