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Adopting leisure-time physical activity after diagnosis of a vascular condition.
Authors: Ramage-Morin PL, Bernier J, Newsom JT, Huguet N, McFarland BH, Kaplan MS Abstract BACKGROUND: A better understanding of factors associated with adopting leisure-time physical activity among people with chronic vascular conditions can help policy-makers and health care professionals develop strategies to promote secondary prevention among older Canadians. DATA AND METHODS: Cross-sectional data from the 1994/1995 National Population Health Survey (NPHS), household component, and the 2007/2008 Canadian Community Health Survey were used to estimate the prevalence of inactivity. Longitudinal data from eight...
Source: Health Reports - November 14, 2014 Category: Global & Universal Tags: Health Rep Source Type: research

Vascular Disease
Vascular medicine–related diseases are the most common cause of death and disability in the United States; they affect more than 30 million people and account for more than $100 billion of health care expenditure every year. Vascular medicine is a relatively new specialty and encompasses multiple disciplines, including vascular surgery, interventional radiology, cardiology, rheumatology, hematology, and neurology. As cardiologists, we are looked upon as experts in cardiovascular disease and are often the first health care contact for patients with vascular disease.
Source: Cardiology Clinics - November 29, 2014 Category: Cardiology Authors: Leonardo C. Clavijo Tags: Preface Source Type: research

Development of Scaffolds for Vascular Tissue Engineering: Biomaterial Mediated Neovascularization.
Abstract Cardiovascular diseases remain the leading causes of mortality or disabled quality of life for people over the world. The necessity of neovascularization is essential for reestablished the tissue functions after a major lesion that occurs in patients with cardiovascular disorders, such as ischemia, atherosclerosis, diabetes, peripheral vascular disease, and burn wounds. This review focuses on the recent data regarding the polymers and scaffolds that are used for improving neovascularization with emphasis the biocompatibility and mechanisms involved in stem cells proliferation, migration, adherence, differ...
Source: Current Stem Cell Research and Therapy - December 3, 2015 Category: Stem Cells Authors: Iordache F, Mihai Grumezescu A, Maniu H, Curutiu C Tags: Curr Stem Cell Res Ther Source Type: research

Water-soluble chitosan regulates vascular remodeling in hypertension via NFATc1
Conclusion In both cell and animal experiments, we succefully confirmed the regulatory effects of WSC on vascular remodeling in hypertension. Based on the present results, WSC-inhibited vascular remodeling may be related to the modulation on NFATc1 expression. Our experiment provides a solid basis for the clinical application of WSC on hypertension.
Source: European Journal of Heart Failure Supplements - May 23, 2016 Category: Cardiology Authors: Du, M., Kou, L., Li, S. Tags: Articles Source Type: research

Harnessing the Power of SIRT1 and Non-coding RNAs in Vascular Disease.
Abstract Noncommunicable diseases (NCDs) contribute to a significant amount of disability and death in the world. Of these disorders, vascular disease is ranked high, falls within the five leading causes of death, and impacts multiple other disease entities such as those of the cardiac system, nervous system, and metabolic disease. Targeting the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) pathway and the modulation of micro ribonucleic acids (miRNAs) may hold great promise for the development of novel strategies for the treatment of vascular disease since each of these ...
Source: Current Neurovascular Research - November 28, 2016 Category: Neurology Authors: Maiese K Tags: Curr Neurovasc Res Source Type: research

Correlations between Cerebral Vascular Reactivity Deficits and Brain Parenchymal Volumes after Chronic Moderate/Severe TBI (P4.215)
Conclusions:These findings suggest that regional deficits in CVR in chronic TBI are not a consequence of parenchymal neural injury, and likely are a direct measure of vascular dysfunction. Additionally, these findings further support the hypothesis that vascular and neuronal injuries represent distinct TBI endophenotypes, which may respond to different interventional treatments and modalities, and need to be studied independently.Study Supported by: MCNCoE & CNRM, DoDDisclosure: Dr. Flesher has nothing to disclose. Dr. Haber has nothing to disclose. Dr. Amyot has nothing to disclose. Dr. Silverman has nothing to disclo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Flesher, K., Haber, M., Amyot, F., Silverman, E., Moore, C., Kenney, K., Diaz-Arrastia, R. Tags: Neuro-rehabilitation: Mechanism of Recovery Source Type: research

Total Percutaneous Cardiopulmonary Bypass for Robotic and Endoscopic Atrioventricular Valve Surgery
In this report, we provide a stepwise description of our total percutaneous peripheral cardiopulmonary bypass technique.
Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery - July 1, 2017 Category: Cardiovascular & Thoracic Surgery Tags: How-To-Do-It Articles Source Type: research

Identifying people with a learning disability: an advanced search for general practice.
CONCLUSION: The Read Code search supported practices to populate their registers and was quick to run and review, making it a viable choice to support register revalidation. However, it did not find large numbers of people eligible for the LD register who were previously unidentified by their practice, suggesting that additional complementary methods are required to support practices to validate their registers. PMID: 29061717 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - October 23, 2017 Category: Primary Care Authors: Russell AM, Bryant L, House A Tags: Br J Gen Pract Source Type: research

Defining a unified vascular phenotype in systemic sclerosis
This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - November 16, 2017 Category: Rheumatology Authors: Yannick Allanore, Oliver Distler, Marco Matucci ‐Cerinic, Christopher P Denton Tags: Review Article Source Type: research

Review: Defining a Unified Vascular Phenotype in Systemic Sclerosis
Microcirculation impairment and related vasculopathy are hallmarks of systemic sclerosis (SSc). Digital ulceration is second only to Raynaud's phenomenon as a vascular complication occurring in patients with SSc. Digital ulcers are painful and generate disability. Furthermore, patients may develop recurrent digital ulcers, and it is reasonable to question whether the outcomes of such patients might be different from those of patients who are not affected. Recently, several registries have provided relevant information about digital ulcers. Male sex and severe skin disease appear to be the main associated factors observed i...
Source: Arthritis and Rheumatism - January 22, 2018 Category: Rheumatology Authors: Yannick Allanore, Oliver Distler, Marco Matucci ‐Cerinic, Christopher P. Denton Tags: Review Source Type: research

Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair.
Abstract Stroke patients have only limited therapeutic options and often remain with considerable disabilities. To promote neurological recovery, angiogenesis in the ischemic peri-infarct region has been recognized as an encouraging therapeutic target. Despite advances in mechanistic understanding of vascular growth and repair, effective and safe angiogenic treatments are currently missing. Besides the most intensively studied angiogenic growth factors, recent research has indicated that the process of vascular sprouting and migration also requires the participation of guidance molecules, many of which were initia...
Source: Trends in Neurosciences - July 4, 2019 Category: Neuroscience Authors: Rust R, Grönnert L, Weber RZ, Mulders G, Schwab ME Tags: Trends Neurosci Source Type: research

Retrospective study of functional outcomes and disability after non-ischaemic vascular causes of spinal cord dysfunction.
Conclusion: Most patients returned home with significantly improved functional outcomes compared to rehabilitation admission, but with the majority having ongoing major disabilities based on FIM motor scores. PMID: 31403383 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - August 15, 2019 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Neonatal cerebral hypoxia-ischemia in mice triggers age-dependent vascular effects and disabilities in adults; implication of tissue plasminogen activator (tPA).
Abstract Neonatal encephalopathy frequently results from hypoxia-ischemia (HI) or inflammation in preterm or term neonates. Neuropathology depends on cerebral development at insult time, but the poor correlation of neuromotor, cognitive, and behavioral disabilities in infancy with initial imaging and clinical records precludes early prognosis. The Rice-Vannucci HI procedure was applied to wild type and tissue plasminogen activator knockout (tPA-KO) mice as surrogates for human preterm (with five-day-old postnatal (P5) mice) or human term (with ten-day-old postnatal (P10) mice). Acute and delayed T2-magnetic resona...
Source: Experimental Neurology - November 3, 2019 Category: Neurology Authors: Dupré N, Arabo A, Orset C, Maucotel J, Detroussel Y, Hauchecorne M, Gonzalez BJ, Marret S, Vivien D, Leroux P Tags: Exp Neurol Source Type: research

Is functional disability a risk equivalent to the comorbidity of multi-vascular risk factors for cardiovascular events and all-cause death? A 5-year follow-up study.
Conclusion: FD 3-6 months after ischemic stroke is a risk equivalent to comorbidity of conventional vascular risk factors for the incidence of cardiovascular events and mortality of all-cause death. PMID: 32172677 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - March 14, 2020 Category: Neurology Authors: Guan S, Zhang X, Liu H, Zhang Y, Hou C, Ji X, Fang X Tags: Top Stroke Rehabil Source Type: research

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis
DiscussionAntiplatelet –HTPR may predict risks of recurrent vascular events/outcomes in CVD patients. Given the heterogeneity between studies, further prospective, multi-centre studies are warranted.
Source: Journal of Neurology - June 8, 2020 Category: Neurology Source Type: research