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Drug: Metformin

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Total 6341 results found since Jan 2013.

Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice.
Abstract The association of diabetes and cognitive decline may indicate that high sugar level might be a risk factor for Alzheimer's disease. A collective term 'diabetes associated cognitive decline' (DACD) has been coined for the patients with type 2 diabetes mellitus showing decline in their cognitive function, especially weak episodic memory, cognitive inflexibility and poor psychomotor performance leading towards Alzheimer's disease. However, at present, no specific treatment exists for the prevention and/or treatment of DACD. Genistein, an isoflavone phytoestrogen, reveals neuroprotective effects in many expe...
Source: Chemico-Biological Interactions - February 28, 2017 Category: Molecular Biology Authors: Rajput MS, Sarkar PD Tags: Chem Biol Interact Source Type: research

Tm-09 * inhibition of glioma cancer stem cell by combination of 2-deoxyglucose and metformin
This study investigated whether the combination of 2-deoxygluxose (2-DG) and metformin inhibit gCSCs. We evaluated the antitumor activity of 2-DG, metformin alone, and combination of 2-DG and metformin. 2-DG alone did hardly affect cell viability, however, metformin alone showed dose-dependent antitumor effect on gCSC line. Moreover, 2-DG in combination either with 5mmol/L or 15mmol/L of metformin induced 100% of cell death. When gCSC line was treated with combined 2-DG and metformin, surface markers of gCSC such as Nestin, CD133 and stemness-regulating transcription factors including Sox-2 and Notch4 were both suppressed....
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Kim, E., Kim, P., Kang, S.-G. Tags: TUMOR METABOLISM Source Type: research

Pomegranate and licorice juices modulate metformin pharmacokinetics in rats.
CONCLUSION: Pre-administration of pomegranate significantly reduced metformin maximum plasma concentration from 1410 to 1031 ng/ml. On the other hand, pre-administration of licorice significantly delayed metformin reaching its maximum plasma concentration. In conclusion, pre-administration of pomegranate may potentially reduce efficacy of metformin while licorice might delay metformin action. Thus, both juices should be cautiously administrated with metformin, the mainstay drug for type-2 diabetes mellitus management. PMID: 27618606 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - September 13, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Nimg-39. cytostatic agents combined with tumor treating fields (ttfields) in glioma cell lines
TTFields are low-intensity intermediate frequency alternating electric fields that disrupt mitosis. This innovative treatment approach is approved for the treatment of patients with recurrent glioblastoma and a recent phase 3 study demonstrated superior progression free and overall survival in patients with newly diagnosed glioblastoma when TTFields were added to standard of care. The goal of this study was to determine possible additive or synergistic effects of TTFields in combination with different cytostatic agents that were chosen based on their known pre-clinical anti-glioma activity, oral administration, safety, and...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Groves, M., Schneiderman, R., Zeevi, E., Voloshin, T., Giladi, M., Kirson, E., Weinberg, U. Tags: NEURO-IMAGING Source Type: research

Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice
Publication date: Available online 1 March 2017 Source:Chemico-Biological Interactions Author(s): Mithun Singh Rajput, Purnima Dey Sarkar The association of diabetes and cognitive decline may indicate that high sugar level might be a risk factor for Alzheimer's disease. A collective term ‘diabetes associated cognitive decline’ (DACD) has been coined for the patients with type 2 diabetes mellitus showing decline in their cognitive function, especially weak episodic memory, cognitive inflexibility and poor psychomotor performance leading towards Alzheimer's disease. However, at present, no specific treatment exists for ...
Source: Chemico Biological Interactions - March 1, 2017 Category: Biochemistry Source Type: research

Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus
Publication date: Available online 3 June 2017 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Yi-Chun Kuan, Kuang-Wei Huang, Cheng-Li Lin, Chaur-Jong Hu, Chia-Hung Kao Epidemiological evidence reveals that patients with type 2 diabetes mellitus (T2DM) have an increased risk of neurodegenerative diseases (NDs), including dementia and Parkinson's disease (PD). The effects of metformin exposure on dementia and PD risk in patients with T2DM are unknown. We evaluated the effects of metformin exposure on the risk of dementia and PD in patients with T2DM. We performed a cohort study by using Tai...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - June 3, 2017 Category: Psychiatry Source Type: research

Gestational diabetes - is diet and insulin the only solution?
Authors: Abstract Gestational diabetes (GDM) is a relatively common complication of pregnancy. Maternal hyperglycemia causes many serious side effects for mothers, fetuses and newborns. In 90% of women diagnosed with GDM, a dietary treatment results in satisfactory levels of blood glucose. The remaining 10% require insulin therapy to achieve the recommended glycemic levels. The majority of recent studies show the efficiency of metformin in gestational diabetes and prove that it is not a cause for any harmful side effects to the embryo and/or fetus. Metformin is an effective alternative to insulin in glycemic contr...
Source: Neuroendocrinology Letters - November 8, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress.
CONCLUSIONS Metformin can improve the neurological function and oxidative stress status of acute stroke patients with type 2 diabetes, and its mechanism may be related to the AMPK/mTOR signaling pathway and oxidative stress. PMID: 30905926 [PubMed - in process]
Source: Medical Science Monitor - March 26, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants
The objective of this narrative review is to critically appraise the literature surrounding drugs commonly used as anti-hyperglycemic agents and their effects on the brain, while discussing their potential as a new treatment for mental illnesses, and specifically, mood disorders.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 26, 2019 Category: Psychiatry Source Type: research

Hemichorea in ketotic hyperglycemia with hyperdense striatum mimicking hemorrhagic transformation in a patient using apixaban.
CONCLUSION: Diabetic striatopathy is a rare but treatable disorder and should be considered in patients with poorly controlled diabetes who present with hemichorea. PMID: 33307650 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - December 16, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

The safety and efficacy of metformin in fragile X syndrome: An open-label study
Publication date: Available online 20 March 2021Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Mélodie Proteau-Lemieux, Angélina Lacroix, Luc Galarneau, François Corbin, Jean-François Lepage, Artuela Çaku
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 21, 2021 Category: Psychiatry Source Type: research

In search of the mechanisms of metformin in cancer
In search of the mechanisms of metformin in cancer, Published online: 26 September 2018; doi:10.1038/s41574-018-0104-3In search of the mechanisms of metformin in cancer
Source: Nature Reviews Endocrinology - September 26, 2018 Category: Endocrinology Authors: Alan Morris Source Type: research

Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database
rman & S J Freedland
Source: Prostate Cancer and Prostatic Diseases - October 8, 2013 Category: Urology & Nephrology Authors: E H AllottM R AbernL GerberC J KetoW J AronsonM K TerrisC J KaneC L AmlingM R CooperbergP G MoormanS J Freedland Tags: metformin diabetes biochemical recurrence outcomes Source Type: research

Search list of recalled metformin products
Source: FDA Center for Drug Evaluation and Research - What's New - July 13, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Melatonin and Metformin Counteract Cognitive Dysfunction Equally in Male Rats with Doxorubicin-induced Chemobrain
Neurotoxicology. 2022 Dec 1:S0161-813X(22)00193-0. doi: 10.1016/j.neuro.2022.11.012. Online ahead of print.NO ABSTRACTPMID:36463981 | DOI:10.1016/j.neuro.2022.11.012
Source: Neurotoxicology - December 4, 2022 Category: Neurology Authors: Titikorn Chunchai Hiranya Pintana Apiwan Arinno Benjamin Ongnok Patcharapong Pantiya Thawatchai Khuanjing Nanthip Prathumsap Chayodom Maneechote Nipon Chattipakorn Siriporn C Chattipakorn Source Type: research