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Drug: Metformin
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Clinical Efficacy of Different Doses of Canagliflozin Combined with Metformin in the Treatment of Type 2 Diabetes: Meta-Analysis
CONCLUSION: The meta-analysis demonstrates that high doses of canagliflozin combined with metformin may be potentially effective in patients with T2DM, as evidenced by LS means of HbA1c and FPG, and the above conclusions need to be verified by more high-quality studies.PMID:37499149
Source: Alternative Therapies in Health and Medicine - July 27, 2023 Category: Complementary Medicine Authors: GuangZhi Li Dongmei Zhang Jie Ni Shizhen Wang Source Type: research
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: Am J Physiol Renal P... - July 27, 2023 Category: Urology & Nephrology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research
Primary Hyperparathyroidism overlapping with Multiple Sclerosis: a catastrophic marriage
Acta Biomed. 2023 Jul 24;94(S1):e2023128. doi: 10.23750/abm.v94iS1.14446.ABSTRACTPrimary hyperparathyroidism (PHPT) often leads to neurological or psychiatric disorders, thus mimicking different diseases. Here we present a 77-years old man visited in the Emergency Department complaining for fatigue, multiple falls, nausea, anorexia, and constipation. Symptoms were rapidly worsening, and on admission he appeared sleepy, responsive to verbal stimulus, disoriented, dehydrated, unable to maintain upright position. He suffered from mild, relapsing and remitting Multiple Sclerosis (MS) since the age of 45, at that moment not req...
Source: Acta Bio-Medica : Atenei Parmensis - July 24, 2023 Category: General Medicine Authors: Gianfranco Cervellin Vincenzo Brianti Lorenzo Viani Lucia Feldmann Gianni Rastelli Source Type: research
Pterostilbene ameliorates type-2 diabetes mellitus - induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain
Brain Res. 2023 Jul 19:148494. doi: 10.1016/j.brainres.2023.148494. Online ahead of print.ABSTRACTOne of the most serious mental health comorbidities associated with diabetes mellitus is depression. The occurrence is almost double in type 2 diabetes mellitus (T2DM) compared with the general population. Pterostilbene (PTE), a dimethylated analog of resveratrol, has been reported for significant neuroprotective, anti-inflammatory, hypolipidemic, hypoglycaemic and antioxidant effects. However, its effect on diabetes-induced depression-like behavior (DID) has not been studied. The current study aimed at studying the effects of...
Source: Brain Research - July 21, 2023 Category: Neurology Authors: Rashmi Patil Urmila Aswar Nishant Vyas Source Type: research
Pterostilbene ameliorates type-2 diabetes mellitus - Induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain
Brain Res. 2023 Jul 20;1817:148494. doi: 10.1016/j.brainres.2023.148494. Online ahead of print.ABSTRACTOne of the most serious mental health comorbidities associated with diabetes mellitus is depression. The occurrence is almost double in type 2 diabetes mellitus (T2DM) compared with the general population. Pterostilbene (PTE), a dimethylated analog of resveratrol, has been reported for significant neuroprotective, anti-inflammatory, hypolipidemic, hypoglycaemic and antioxidant effects. However, its effect on diabetes-induced depression-like behavior (DID) has not been studied. The current study aimed at studying the effec...
Source: Brain Research - July 21, 2023 Category: Neurology Authors: Rashmi Patil Urmila Aswar Nishant Vyas Source Type: research
The mechanism of metformin combined with total flavonoids of Rhizoma Drynariae on ovariectomy-induced osteoporotic rats
In conclusion, Met combined with TFRD ameliorated bone mass in osteoporotic rats through regulating Wnt/β-catenin signaling pathway and OPG/RANKL/RANK axis.PMID:37473680 | DOI:10.1016/j.biopha.2023.115181
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 20, 2023 Category: Drugs & Pharmacology Authors: Ningning Jiang Hui Jin Kun Yang Zhongyuan Zhang Wenshu Xu Xiaoxue Chen Zhenhua Zhang Hui Xu Source Type: research
Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response
In conclusion, our study suggests that the synergistic effects of MET and glucose deprivation suppress cell proliferation in TNBC by activating pro-apoptotic molecules through UPRER stress. These findings have potential implications for the anti-tumor application of MET in TNBC.PMID:37473529 | DOI:10.1016/j.bbrc.2023.07.029
Source: Cell Research - July 20, 2023 Category: Cytology Authors: Ying Li Qingqian Zhang Jintao Yang Weiping He Yulan Jiang Yu Chen Yifan Wang Source Type: research
Inhibition of protein Kinase C- α and activation of ezrin by < em > Lactobacillus < /em > < em > acidophilus < /em > restore Na < sup > + < /sup > /H < sup > + < /sup > exchange activity and fluid absorption in < em > db/db < /em > mice
In this study, we investigated whether NHE3 expression is altered in type 2 diabetic intestine and the underlying mechanism that dysregulates NHE3. NHE3 expression in the brush border membrane (BBM) of the intestine of diabetic mice and humans was decreased. Protein kinase C (PKC) activation is associated with pathologies of diabetes and immunofluorescence analysis revealed increased BBM PKCα abundance. Inhibition of PKCα increased NHE3 BBM abundance and NHE3-mediated intestinal fluid absorption in db/db mice. Previous studies have shown that Lactobacillus acidophilus (LA) stimulates intestinal ion transporters. LA incre...
Source: Am J Physiol Endocri... - July 19, 2023 Category: Endocrinology Authors: Yiran Han Shanthi Srinivasan C Chris Yun Source Type: research
