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Drug: Estradiol

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Total 6465 results found since Jan 2013.

Biphasic modulation of neuro- and interrenal steroidogenesis in juvenile African sharptooth catfish (Clarias gariepinus) exposed to waterborne di-(2-ethylhexyl) phthalate.
Abstract Receptor (i.e genomic) and non-receptor (or non-genomic) effects of endocrine toxicology have received limited or almost non-existent attention for tropical species and regions. In the present study, we have studied the effects of di-(2-ethylhexyl) phthalate (DEHP) on neuro- and interrenal steroidogenesis of the African catfish (Clarias gariepinus) using molecular, immunochemical and physiological approaches. Juvenile fish (mean weight and length: 5.6 ± 0.6g and 8.2 ± 1.2 cm, respectively), were randomly distributed into ten 120 L rectangular glass tanks containing 60 L of dechlorinated tap water, at 50...
Source: General and Comparative Endocrinology - September 14, 2017 Category: Endocrinology Authors: Arukwe A, Ibor OR, Adeogun AO Tags: Gen Comp Endocrinol Source Type: research

High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets
This study examined the interaction of E and diet in surgically menopausal nonhuman primates with a 2×2 block design. Marmosets (Callithrix jacchus; n =4/group) were placed on control-low fat diet (LFD; 14%kcal from fat) or high fat diet (HFD; 28%kcal from fat) 1month prior to ovariectomy (Ovx). Empty (placebo) or E-filled Silastic capsules were implanted immediately following Ovx surgery. Treatments extended 6months. The established groups were: placebo+LFD, E+LFD, placebo+HFD, or E+HFD. At necropsy, the brain was flushed with saline and harvested. The midbrain was dissected and a small block containing the dorsal raphe ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 8, 2015 Category: Psychiatry Source Type: research

Estrogen levels modify scopolamine-induced amnesia in gonadally intact rats
Publication date: 4 August 2014 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 53 Author(s): André de Macêdo Medeiros , Geison Souza Izídio , Diego Silveira Sousa , Priscila Tavares Macedo , Anatildes Feitosa Silva , Victor Kenji Medeiros Shiramizu , Alicia Cabral , Alessandra Mussi Ribeiro , Regina Helena Silva Previous studies suggested that estrogen plays a role in cognitive function by modulating the cholinergic transmission. However, most of the studies dealing with this subject have been conducted using ovariectomized rats. In the present study we evaluated the effects of physiolog...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 8, 2015 Category: Psychiatry Source Type: research

Immediate effect of blue-enhanced light on reproductive hormones in women.
CONCLUSION: Moderately bright blue-enhanced white light, compared to matched-by-irradiance red light, transiently (within 22 minutes) and mildly stimulated morning secretion of follicle-stimulating hormone in women in mid-to-late follicular phase of their menstrual cycle suggesting a direct functional link between the light and reproductive system. PMID: 25789589 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Effects of 17beta-estradiol and IGF-1 on L-type voltage-activated and stretch-activated calcium currents in cultured rat cortical neurons.
CONCLUSION: Both hormones regulate voltage-activated calcium channels in a synergistic way, but only 17β-estradiol has an inhibitory effect on stretch-activated calcium channels. These effects are not mediated by classical receptors and may be relevant to the neuroprotective effects of both hormones because they diminish calcium entry into the neuron and decrease the possibility for the onset of apoptotic signaling. PMID: 25702302 [PubMed - indexed for MEDLINE]
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Differential effect of the 17β-aminoestrogens prolame, butolame and pentolame in anxiety and depression models in rats
Publication date: Available online 31 July 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): C. Lemini, E. García-Albor, B. Cruz-López, G. Matamoros-Trejo, L. Martínez-Mota Estrogens of clinical use produce consistent antidepressant- and anxiolytic-like effects in animal models of menopause. Regulation of the hypothalamic-pituitary-adrenal (HPA) or stress axis, has been proposed as a pathway through which estrogens improve affective-like behaviors. Anticoagulant 17β-aminoestrogens (17β-AEs) butolame and pentolame mimic some effects of estradiol (E2), i.e. on female rodent sex...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 2, 2015 Category: Psychiatry Source Type: research

Poor responders in IVF - is there any evidence-based treatment for them?
Authors: Szymusik I, Marianowski P, Zygula A, Wielgos M Abstract Despite the vast experience in controlled ovarian hyperstimulation, there are still women who respond poorly to gonadotropins, which results in few oocytes at retrieval, reduced number of embryos for transfer and consequently unsatisfactory pregnancy rates. Although such patients are quite common in IVF practice, the exact prevalence of so-called "poor responders" is difficult to estimate due to the variety of applied definitions. The urgent need for an internationally accepted definition of poor ovarian response (POR) was addressed by an ESHRE Worksh...
Source: Neuroendocrinology Letters - August 29, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Morphine Inhibited the Rat Neural Stem Cell Proliferation Rate by Increasing Neuro Steroid Genesis.
Abstract Up to present, a large number of reports unveiled exacerbating effects of both long- and short-term administration of morphine, as a potent analgesic agent, on opium-addicted individuals and a plethora of cell kinetics, although contradictory effect of morphine on different cells have been introduced until yet. To address the potent modulatory effect of morphine on neural multipotent precursors with emphasis on endogenous sex-related neurosteroids biosynthesis, we primed the rat neural stem cells isolated from embryonic rat telencephalon to various concentrations of morphine including 10, 20, 50 and 100 ...
Source: Neurochemical Research - January 30, 2016 Category: Neuroscience Authors: Feizy N, Nourazarian A, Rahbarghazi R, Nozad Charoudeh H, Abdyazdani N, Montazersaheb S, Narimani M Tags: Neurochem Res Source Type: research

Exposure of rats to exogenous endocrine disruptors 17alpha-ethinylestradiol and benzo(a)pyrene and an estrogenic hormone estradiol induces expression of cytochromes P450 involved in their metabolism.
Authors: Borek-Dohalska L, Klusonova Z, Holecova J, Martinkova M, Barta F, Dracinska H, Cajthaml T, Stiborova M Abstract OBJECTIVES: The term "endocrine disruptor" (ED) is used for compounds that mimic or antagonize the effects of endogenous hormones. Synthetic estrogen 17α-ethinylestradiol (EE2) and a human carcinogen benzo[a]pyrene (BaP) are assigned as exogenous endocrine disruptors and an estrogenic hormone estradiol is a natural endogenous disruptor. Here, the potency of these three disruptors administered to rats individually and in combination to induce expression of cytochrome P450 (CYP) enzymes involved i...
Source: Neuroendocrinology Letters - March 8, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Association of testosterone levels and heroin usage characteristics in male heroin users.
CONCLUSIONS: Our data reveal testosterone might promote injection drug use and repeated relapse in male heroin users. PMID: 28650606 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - June 27, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Complete objective response, stable for 5 years, with the Di Bella Method, of multiple-metastatic carcinoma of the breast.
We present a case of a woman with carcinoma of the breast and multiple metastases after right mastectomy, axillary dissection, repeated cycles of chemo and radiotherapy, and estrogen block. Biological method formulated by Prof. L. Di Bella (DBM) produced a complete and stable objective response without toxicity. The DBM includes antiproliferative molecules, such as somatostatin, prolactin and estrogen inhibitors together with differentiating and apoptotic molecules such as melatonin (MLT), Retinoids, Vitamin E, D3, Vit. C, Calcium, Amino sugars, associated with metronomic microdoses of chemotherapy drugs. The blood tests d...
Source: Neuroendocrinology Letters - January 4, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Expression of matrix metalloproteinase enzymes in endometrium of women with abnormal uterine bleeding.
CONCLUSION: Lack of correlation between proMMP-2 and MMP-2 levels suggest different pathway of their activation in AUB. ProMMP-2 is up regulated by estradiol and down regulated by progesterone while MMP-2 levels increase with the length of bleeding. PMID: 29504731 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - March 7, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Estradiol-induced enhancement of fear extinction in female rats: The role of NMDA receptor activation
Publication date: 30 August 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86 Author(s): Bronwyn M. Graham, Elliot Scott Converging cross-species evidence indicates that fear extinction (the laboratory basis of exposure therapy for anxiety disorders) in females is modulated by endogenous and exogenous estradiol. The mechanisms underlying estradiol's influences on fear extinction are largely undefined. However, one likely candidate is the NMDA-receptor (NMDAr), activation of which is necessary for estradiol-mediated enhancements in structural and functional neural plasticity, as well as ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - May 17, 2018 Category: Psychiatry Source Type: research