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Drug: Nicotine
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Total 8521 results found since Jan 2013.
Fishing for a deeper understanding of nicotine effects using zebrafish behavioural models
Publication date: Available online 26 November 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Olga Wronikowska, Agnieszka Michalak, Krystyna Skalicka-Woźniak, Alexander D. Crawford, Barbara BudzyńskaAbstractNicotine, the primary psychoactive component of tobacco, is the most widely used drug of abuse. Although the substance is well-known, there is still a lack of information concerning its long-term neurological and physiological effects and its mechanisms of action. In order to search for new, effective drugs in the therapy of nicotinism, as well as to design new drugs that exert po...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 27, 2019 Category: Psychiatry Source Type: research
Ventral hippocampal nicotinic acetylcholine receptors mediate stress-induced analgesia in mice
Publication date: 2 January 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 56 Author(s): Zahra Ghasemzadeh , Ameneh Rezayof Evidence suggests that various stressful procedures induce an analgesic effect in laboratory animals commonly referred to as stress-induced analgesia (SIA). The aim of the present study was to assess the role of ventral hippocampal (VH) nicotinic acetylcholine receptors (nAChRs) in SIA in adult male NMRI mice. The VHs of animals were bilaterally cannulated and nociceptive threshold was measured using infrared source in a tail-flick apparatus. Acute stress was evok...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 6, 2014 Category: Psychiatry Source Type: research
Regional brain 11Ccarfentanil binding following tobacco smoking
Conclusion The present study demonstrates that BPND changes induced by avnic smoking in OPRM1 *G carriers were blunted compared to the AA carriers. Also *G smokers had less free mu opioid receptor availability in Amy and NAcc.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 20, 2015 Category: Psychiatry Source Type: research
The possible role of maternal bonding style and CHRNB2 gene polymorphisms in smoking and related depressive phenotype
Conclusions Our results highlight the important role of 3′ UTR in the CHRNB2 gene in the shared molecular background of ND and depressive phenotype. Parental bonding style can be suggested as a significant environmental factor in further GxE studies of depression. The presented significant GxE interaction on smoking-related suicidal subphenotype may help establish further investigations on development of more effective and safer smoking cessation and antidepressant agents.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - January 30, 2015 Category: Psychiatry Source Type: research
The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype
Conclusions Our results highlight the important role of 3′ UTR in the CHRNB2 gene in the shared molecular background of ND and depressive phenotype. Parental bonding style can be suggested as a significant environmental factor in further GxE studies of depression. The presented significant GxE interaction on smoking-related suicidal subphenotype may help establish further investigations on development of more effective and safer smoking cessation and antidepressant agents.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 5, 2015 Category: Psychiatry Source Type: research
Classic Hallucinogens in the Treatment of Addictions
Publication date: Available online 14 March 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Michael P. Bogenschutz , Matthew W. Johnson Addictive disorders are very common and have devastating individual and social consequences. Currently available treatment are moderately effective at best. After many years of neglect, there is renewed interest in potential clinical uses for classic hallucinogens in the treatment of addictions and other behavioral health conditions. In this paper we provide a comprehensive review of both historical and recent clinical research on the use of classic ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 16, 2015 Category: Psychiatry Source Type: research
Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.
In this study, we examined the effects of blocking D1 and D2 receptors in the nucleus accumbens shell (AcS), anterior cingulate cortex (ACC), and parietal association cortex (PtA) on nicotine self-administration in rats. Female Sprague-Dawley rats were fitted with jugular catheters and allowed to self-administer nicotine (0.03 mg/kg/infusion) on an FR1 schedule. Rats were fitted with bilateral infusion cannulae to allow infusion of D1 or D2 antagonists (SCH-23390 or haloperidol) into each targeted brain area. Acute local infusions of SCH-23390 (1-4 μg/side) into the AcS and PtA significantly reduced nicotine self-administ...
Source: Neuropharmacology - March 19, 2015 Category: Drugs & Pharmacology Authors: Hall BJ, Slade S, Allenby C, Levin ED Tags: Neuropharmacology Source Type: research
Stress is a principal factor that promotes tobacco use in females
Publication date: Available online 22 April 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Oscar V. Torres , Laura E. O'Dell Tobacco use is a major economic and health problem. It is particularly concerning that women consume more tobacco products, have a more difficult time quitting smoking and are less likely to benefit from smoking cessation therapy than men. As a result, women are at higher risk of developing tobacco-related diseases. Clinical evidence suggests that women are more susceptible to anxiety disorders, and are more likely to smoke in order to cope with stress than me...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - April 28, 2015 Category: Psychiatry Source Type: research
D3 Receptors Mediate Context-Induced Reinstatement of Nicotine Seeking
Publication date: Available online 14 August 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Pamela Sabioni, Patricia Di Ciano, Bernard Le Foll Despite the existence of several treatment options for smoking cessation, the rate of relapse after treatment is very high. We and others have proposed that targeting the dopamine D3 receptor (DRD3) may be a good strategy for treatment of nicotine dependence. In human participants, reintroduction to an environment previously associated with drug-taking may induce relapse. In animals, such phenomenon can be studied using the context-induced...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - August 14, 2015 Category: Psychiatry Source Type: research
Effect of a D3 receptor antagonist on context-induced reinstatement of nicotine seeking
Publication date: 4 January 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 64 Author(s): Pamela Sabioni, Patricia Di Ciano, Bernard Le Foll Despite the existence of several treatment options for smoking cessation, the rate of relapse after treatment is very high. We and others have proposed that targeting the dopamine D3 receptor (DRD3) may be a good strategy for treatment of nicotine dependence. In human participants, reintroduction to an environment previously associated with drug-taking may induce relapse. In animals, such phenomenon can be studied using the context-induced reins...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - September 4, 2015 Category: Psychiatry Source Type: research
Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse
Publication date: 4 February 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 65 Author(s): C.E. Van Skike, S.E. Maggio, A.R. Reynolds, E.M. Casey, M.T. Bardo, L.P. Dwoskin, M.A. Prendergast, K. Nixon Polysubstance abuse of alcohol and nicotine has been overlooked in our understanding of the neurobiology of addiction and especially in the development of novel therapeutics for its treatment. Estimates show that as many as 92% of people with alcohol use disorders also smoke tobacco. The health risks associated with both excessive alcohol consumption and tobacco smoking create an ur...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 4, 2015 Category: Psychiatry Source Type: research
Enhanced vulnerability to tobacco use in persons with diabetes: A behavioral and neurobiological framework
Publication date: 4 February 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 65 Author(s): Laura E. O’Dell, Arbi Nazarian Tobacco use significantly magnifies the negative health complications associated with diabetes. Although tobacco use is strongly discouraged in persons with diabetes, clinical evidence suggests that they often continue to smoke and have more difficulty quitting despite serious contraindications. Here, we suggest that a potential reason for enhanced vulnerability to tobacco use in persons with diabetes is greater rewarding effects of nicotine. This review summariz...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 4, 2015 Category: Psychiatry Source Type: research
Unusual way of suicide by carbon monoxide. Case Report.
CONCLUSIONS: The authors discuss an unusual case of suicide by CO intoxication rarely seen in the area of forensic medicine and toxicology that is specific due to its sophisticated way of execution.
PMID: 26757130 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - January 15, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Genetic polymorphisms by deletion in genes that encode for glutathione S-transferases are associated with nicotine dependence and tobacco use-related medical disorders.
This study comprised 182 tobacco users and 182 controls (neversmokers). GSTM1 and GSTT1 polymorphisms were assessed using a Multiplex- PCR based protocol.
RESULTS: Logistic regression analyses showed a significant association between ND and the GSTM1 and GSTT1 null genotypes. There were no significant associations between GSTT1, GSTM1 and GSTT1/M1 genetic variants and the Fagerström test for ND, age at onset, smoking cessation or a family history of ND. Patients with ND had increased rates of a family ND history and an increased prevalence of cardiovascular disease, hypertension, and lung disease. The null genotypes w...
Source: Neuroendocrinology Letters - January 28, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats
Publication date: 3 June 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 67 Author(s): Adriana Mary Nunes Costa Okamura, Patrícia Xavier L. Gomes, Gersilene V. de Oliveira, Fernanda Yvelize R. de Araújo, Viviane S. Tomaz, Adriano José Maia Chaves Filho, Francisca Cléa F. de Sousa, Silvânia Maria Mendes Vasconcelos, David Freitas de Lucena, Danielle Macêdo Kindling is a form of behavioral sensitization that is related to the progression of several neuropsychiatric disorders such as bipolar disorder. We recently demonstrated that female periadolescent rats are more vulnera...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 12, 2016 Category: Psychiatry Source Type: research
