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Source: Molecules
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Total 1038 results found since Jan 2013.
Molecules, Vol. 27, Pages 5299: Comparative Investigation of Conventional and Innovative Headspace Extraction Methods to Explore the Volatile Content of Human Milk
This study aimed to devise a simple method to extract a wide range of volatile compounds from small-volume human milk samples. Headspace solid phase micro-extraction (HS-SPME) with a Car/PDMS fiber and dynamic headspace extraction (D-HS) with a Tenax or a trilayer sorbent were tested because of their selective affinity for volatiles. Then, innovative variations of these methods were developed to combine their respective advantages in a one-step extraction: Static headspace with multiple SPME fibers (S-HS-MultiSPME), Dynamic headspace with multiple SPME fibers (D-HS-MultiSPME) and dynamic headspace with multiple SPME fibers...
Source: Molecules - August 20, 2022 Category: Chemistry Authors: Sarah Le Roy Catherine Fillonneau Benoist Schaal Carole Prost Ang élique Villière MILKODOR Consortium Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5316: Walnut Prevents Cognitive Impairment by Regulating the Synaptic and Mitochondrial Dysfunction via JNK Signaling and Apoptosis Pathway in High-Fat Diet-Induced C57BL/6 Mice
This study was conducted to evaluate the protective effect of Juglans regia (walnut, Gimcheon 1ho cultivar, GC) on high-fat diet (HFD)-induced cognitive dysfunction in C57BL/6 mice. The main physiological compounds of GC were identified as pedunculagin/casuariin isomer, strictinin, tellimagrandin I, ellagic acid-O-pentoside, and ellagic acid were identified using UPLC Q-TOF/MS analysis. To evaluate the neuro-protective effect of GC, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), 2′,7′-dichlorodihydrofluorecein diacetate (DCF-DA) analysis were conducted in H2O2 and high gluco...
Source: Molecules - August 20, 2022 Category: Chemistry Authors: Jong Hyun Moon Jong Min Kim Uk Lee Jin Yong Kang Min Ji Kim Hyo Lim Lee Hye Rin Jeong Min Ji Go Hyun-Jin Kim Hye Won Park Chul-Woo Kim Sung Jin Park Ho Jin Heo Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5303: Synthesis and In Silico Docking Study towards M-Pro of Novel Heterocyclic Compounds Derived from Pyrazolopyrimidinone as Putative SARS-CoV-2 Inhibitors
s Romdhane
In addition to vaccines, antiviral drugs are essential in order to suppress COVID-19. Although some inhibitor candidates have been determined to target the SARS-CoV-2 protein, there is still an urgent need to continue researching novel inhibitors of the SARS-CoV-2 main protease ‘Omicron P132H’, a protein that has recently been discovered. In the present study, in the search for therapeutic alternatives to treat COVID-19 and its recent variants, we conducted a structure-based virtual screening using docking studies for a new series of pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives ...
Source: Molecules - August 19, 2022 Category: Chemistry Authors: Mabrouk Horchani Niels V. Heise Ren é Csuk Hichem Ben Ben Jannet Abdel Halim Harrath Anis Romdhane Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5239: CK2 Inhibition and Antitumor Activity of 4,7-Dihydro-6-nitroazolo1,5-apyrimidines
eglova
Oleg G. Makeev
Today, cancer is one of the most widespread and dangerous human diseases with a high mortality rate. Nevertheless, the search and application of new low-toxic and effective drugs, combined with the timely diagnosis of diseases, makes it possible to cure most types of tumors at an early stage. In this work, the range of new polysubstituted 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines was extended. The structure of all the obtained compounds was confirmed by the data of 1H, 13C NMR spectroscopy, IR spectroscopy, and elemental analysis. These compounds were evaluated against human recombinant CK2 usi...
Source: Molecules - August 17, 2022 Category: Chemistry Authors: Daniil N. Lyapustin Svetlana K. Kotovskaya Ilya I. Butorin Evgeny N. Ulomsky Vladimir L. Rusinov Denis A. Babkov Alexander A. Pokhlebin Alexander A. Spasov Vsevolod V. Melekhin Maria D. Tokhtueva Anna V. Shcheglova Oleg G. Makeev Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5232: Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis
Conclusions: Resveratrol has a statistically significant dose–response effect on glucose concentrations, HbA1c, and insulin levels; however, there is not enough scientific evidence to propose a therapeutic dose.
Source: Molecules - August 16, 2022 Category: Chemistry Authors: Beatriz Isabel Garc ía-Martínez Mirna Ruiz-Ramos Jos é Pedraza-Chaverri Edelmiro Santiago-Osorio V íctor Manuel Mendoza-Núñez Tags: Review Source Type: research
Molecules, Vol. 27, Pages 5198: Electric Current Generation by Increasing Sucrose in Papaya Waste in Microbial Fuel Cells
The objective of this research was to observe the influence on the generation of bioelectricity of sucrose, with different percentages (0%, 5%, 10% and 20%), in papaya waste using microbial fuel cells (MFCs). It was possible to generate voltage and current peaks of 0.955 V and 5.079 mA for the cell with 20% sucrose, which operated at an optimal pH of 4.98 on day fifteen. In the same way, the internal resistance values of all the cells were influenced by the increase in sucrose, showing that the cell without sucrose was 0.1952 ± 0.00214 KΩ and with 20% it was 0.044306 ± 0.0014 K&a...
Source: Molecules - August 15, 2022 Category: Chemistry Authors: Segundo Rojas-Flores Magaly De La Cruz-Noriega Santiago M. Benites Daniel Delf ín-Narciso Angelats-Silva Luis Felix D íaz Cabanillas-Chirinos Luis Gallozzo Cardenas Moises Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5169: Marker Substances in the Aroma of Truffles
as Koch
The aim of this study was to identify specific truffle marker substances within the truffle aroma. The aroma profile of different truffle species was analyzed using static headspace sampling with gas chromatography mass spectrometry analysis (SHS/GC-MS). Possible marker substances were identified, taking the additional literature into account. The selected marker substances were tested in an experiment with 19 truffle dogs. The hypothesis “If trained truffle dogs recognize the substances as supposed truffles in the context of an experiment, they can be regarded as specific” was made....
Source: Molecules - August 13, 2022 Category: Chemistry Authors: Ruben Epping Lilly Bliesener Tilman Weiss Matthias Koch Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5143: Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF- & kappa;B Signaling Cascade in RAW 264.7 Cells
This study exhibits the value of esculetin for the treatment of LTA-induced inflammation by targeting NF-κB signaling pathways via its antioxidant properties.
Source: Molecules - August 12, 2022 Category: Chemistry Authors: Thanasekaran Jayakumar Chun-Jen Huang Ting-Lin Yen Chih-Wei Hsia Joen-Rong Sheu Periyakali Saravana Bhavan Wei-Chieh Huang Cheng-Ying Hsieh Chih-Hsuan Hsia Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5150: Electrochemical Bottom-Up Synthesis of Chiral Carbon Dots from L-Proline and Their Application as Nano-Organocatalysts in a Stereoselective Aldol Reaction
izio Vetica
Chirality is undoubtedly a fundamental property of nature since the different interactions of optically active molecules in a chiral environment are essential for numerous applications. Thus, in the field of asymmetric synthesis, the search for efficient, sustainable, cost-effective and recyclable chiral catalysts is still the main challenge in organic chemistry. The field of carbon dots (CDs) has experienced tremendous development in the last 15 years, including their applications as achiral catalysts. Thus, understanding the implications of chirality in CDs chemistry could be of utmost importance to achie...
Source: Molecules - August 12, 2022 Category: Chemistry Authors: Martina Bortolami Ingrid Izabela Bogles Cecilia Bombelli Fabiana Pandolfi Marta Feroci Fabrizio Vetica Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5128: Traditional Use, Phytochemical Profiles and Pharmacological Properties of Artemisia Genus from Central Asia
In conclusion, the examination of details between different Artemisia species in our research has shown that plant materials are good as an antioxidant and eznyme inhibitory functional natural source.
Source: Molecules - August 11, 2022 Category: Chemistry Authors: Aliya Nurlybekova Aidana Kudaibergen Aizhan Kazymbetova Magzhan Amangeldi Aizhamal Baiseitova Meirambek Ospanov Haji Akber Aisa Yang Ye Mohamed Ali Ibrahim Janar Jenis Tags: Article Source Type: research
Molecules, Vol. 27, Pages 5095: Natural Polyphenols as SERCA Activators: Role in the Endoplasmic Reticulum Stress-Related Diseases
ova
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is a key protein responsible for transporting Ca2+ ions from the cytosol into the lumen of the sarco/endoplasmic reticulum (SR/ER), thus maintaining Ca2+ homeostasis within cells. Accumulating evidence suggests that impaired SERCA function is associated with disruption of intracellular Ca2+ homeostasis and induction of ER stress, leading to different chronic pathological conditions. Therefore, appropriate strategies to control Ca2+ homeostasis via modulation of either SERCA pump activity/expression or relevant signaling pathways may represent a useful approach to comb...
Source: Molecules - August 10, 2022 Category: Chemistry Authors: Jana Viskupicova Petronela Rezbarikova Tags: Review Source Type: research
Molecules, Vol. 27, Pages 5072: Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy
n Safi
Yuan Seng Wu
Rusli Nordin
Mohammad Nazmul Hasan Maziz
Vinoth Kumarasamy
Pei Teng Lum
Neeraj Kumar Fuloria
Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R...
Source: Molecules - August 9, 2022 Category: Chemistry Authors: Shivkanya Fuloria Mahendran Sekar Farrah Syazana Khattulanuar Siew Hua Gan Nur Najihah Izzati Mat Rani Subban Ravi Vetriselvan Subramaniyan Srikanth Jeyabalan M. Yasmin Begum Kumarappan Chidambaram Kathiresan V. Sathasivam Sher Zaman Safi Yuan Seng Wu Rus Tags: Review Source Type: research
Molecules, Vol. 27, Pages 5045: Isolation and Characterization of Galloylglucoses Effective against Multidrug-Resistant Strains of Escherichia coli and Klebsiella pneumoniae
Holzgrabe
The search for new antibiotics against multidrug-resistant (MDR), Gram-negative bacteria is crucial with respect to filling the antibiotics development pipeline, which is subject to a critical shortage of novel molecules. Screening of natural products is a promising approach for identifying antimicrobial compounds hosting a higher degree of novelty. Here, we report the isolation and characterization of four galloylglucoses active against different MDR strains of E. coli and K. pneumoniae. A crude acetone extract was prepared from Paeonia officinalis Linnaeus leaves, and bioautography-guided isolation of activ...
Source: Molecules - August 8, 2022 Category: Chemistry Authors: Nelson E. Masota Knut Ohlsen Curd Schollmayer Lorenz Meinel Ulrike Holzgrabe Tags: Article Source Type: research
Molecules, Vol. 27, Pages 4978: Non-Invasive and Confirmatory Differentiation of Hermaphrodite from Both Male and Female Cannabis Plants Using a Hand-Held Raman Spectrometer
In this study, we investigate the potential of Raman spectroscopy (RS), an emerging sensing technique that can be used to probe plant biochemistry. Our results show that the biochemistry of male, female and hermaphroditic cannabis plants is drastically different which allows for their confirmatory identification using a hand-held Raman spectrometer. Furthermore, the coupling of machine learning approaches enables the identification of hermaphrodites with 98.7% accuracy, whereas both male and female plants can be identified with 100% accuracy. Considering the label-free, non-invasive and non-destructive nature of RS, the de...
Source: Molecules - August 5, 2022 Category: Chemistry Authors: Nicolas K. Goff James F. Guenther John K. Roberts Mickal Adler Michael Dalle Molle Greg Mathews Dmitry Kurouski Tags: Article Source Type: research
Molecules, Vol. 27, Pages 4989: In Vitro Cytotoxic Activity of African Plants: A Review
a Pinho
In African countries, cancer not only is a growing problem, but also a challenge because available funding and resources are limited. Therefore, African medicinal plants play a significant role in folk medicine and some of them are traditionally used for the treatment of cancer. The high mortality rate and adverse effects associated with cancer treatments have encouraged the search for novel plant-based drugs, thus, some African plants have been studied in recent years as a source of molecules with proven cytotoxicity. This review aims to discuss the cytotoxic activity, in vitro, of African plant crude extracts...
Source: Molecules - August 5, 2022 Category: Chemistry Authors: Isabel Canga Pedro Vita Ana Isabel Oliveira Mar ía Ángeles Castro Cl áudia Pinho Tags: Review Source Type: research
