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Source: Arquivos de Neuro-Psiquiatria
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Total 977 results found since Jan 2013.
Free carnitine and branched chain amino acids are not good biomarkers in Huntington’s disease
Conclusions: Although valine levels were lower in HD carriers and were related to BMI losses observed in pre-symptomatic individuals, none of these metabolites seem to be biomarkers for HD.RESUMO Introdu ção: A doença de Huntington (DH), causada por uma repetição CAG expandida no HTT, não possui tratamento e biomarcadores são necessários para futuros ensaios clínicos. Objetivo: Nosso objetivo foi verificar se os níveis de carnitina livre e aminoácidos de cadeia ramificada se comportam com o potenciais biomarcadores na DH. Métodos: Portadores sintomáticos e assintomáticos e controles foram recrutados. Idade, s...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Stroke-mimics in stroke-units. Evaluation after changes imposed by randomized trials
Conclusion: Considering that the number of patients admitted for stroke treatment will increase even further with a larger therapeutic window for mechanical thrombectomy and for thrombolysis, a diagnostic decision-making algorithm for stroke patients is required in order to reinforce the suspicion of stroke indicating an urgent MRI.Resumo Uma janela terap êutica maior para o tratamento do AVC exige uma mudança significativa na organização dos serviços de emergência, para evitar o aumento do número de exames de imagem e indiretamente o tempo de tratamento. Objetivo: destacar a relação entre avaliação clínica mai...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Assessment of ventilatory function in patients with spinocerebellar ataxia type 2
Conclusion: Ventilatory dysfunction, even when asymptomatic, is related to balance impairment, independence, and ataxia severity in individuals with SCA2.Resumo Disfun ção ventilatória subclínica tem sido observada em indivíduos com ataxias espinocerebelares (SCA). Não existem estudos relacionando disfunção ventilatória ao declínio clínico e funcional na SCA2. Objetivo: Avaliar a relação dos valores de Pico de Fluxo Expiratório (PFE), Pressão Insp iratória Máxima (PIMAX) e presença de queixas respiratórias com idade, tempo de doença, idade de início dos sintomas, escore de equilíbrio, independência p...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Demyelination in experimental intraventricular neurocysticercosis
In conclusion, the presence of cysticerci and the consequent inflammation were able to promote initial periventricular demyelination followed by parenchymatous demyelination as the infection progressed.Resumo A neurocisticercose (NCC) é classificada como uma doença tropical negligenciada que afeta principalmente a América Latina e a África, apesar de alguns relatos na América do Norte e na Europa. A NCC é responsável por cerca de 30% dos casos de epilepsia em países endêmicos. Estas lesões parecem ter estreita relação com o estádio de desenvolvimento, com a localização e o número de parasitas, bem como a re...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Gliosarcomas: magnetic resonance imaging findings
Conclusion: These findings are discussed in relation to the general characteristics of GSM reported in the literature.Resumo Introdu ção: O gliossarcoma (GSM) do sistema nervoso central (SNC) é uma neoplasia primária rara, caracterizada pela presença de componentes gliais e sarcomatosos. Objetivo: Nosso objetivo é descrever os aspectos clínicos e de neuroimagem de três casos com este diagnóstico e correlacioná-los co m os achados patológicos. Também foi realizada uma breve revisão da literatura relevante. Métodos: Três pacientes foram avaliados por ressonância magnética (RM), e biópsias confirmaram o diag...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
A concise historical perspective of the area postrema structure and function
ABSTRACT First described by Retzius at the end of the 19th century, the structure in the posterior medulla oblongata, then named area postrema, underwent an intense investigation into its function in the decades that followed. Findings, mainly in animal studies, have partially elucidated its role as an emetic center in the central nervous system. In the second half of the 20th century, this function was associated with reports of syndromes characterized by uncontrollable nausea and vomiting related to structural damage in the area postrema, mainly in the context of demyelinating diseases. At the beginning of the 21st centu...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Intracranial isolated varix mimicking a meningioma: the relevance of modern MRI techniques for reliable diagnosis
ABSTRACT First described by Retzius at the end of the 19th century, the structure in the posterior medulla oblongata, then named area postrema, underwent an intense investigation into its function in the decades that followed. Findings, mainly in animal studies, have partially elucidated its role as an emetic center in the central nervous system. In the second half of the 20th century, this function was associated with reports of syndromes characterized by uncontrollable nausea and vomiting related to structural damage in the area postrema, mainly in the context of demyelinating diseases. At the beginning of the 21st centu...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Adult-onset cerebral X-linked adrenoleukodystrophy presenting as obsessive-compulsive disorder
ABSTRACT First described by Retzius at the end of the 19th century, the structure in the posterior medulla oblongata, then named area postrema, underwent an intense investigation into its function in the decades that followed. Findings, mainly in animal studies, have partially elucidated its role as an emetic center in the central nervous system. In the second half of the 20th century, this function was associated with reports of syndromes characterized by uncontrollable nausea and vomiting related to structural damage in the area postrema, mainly in the context of demyelinating diseases. At the beginning of the 21st centu...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Norberto Luiz Cabral, MD, PhD - (1963‒2019)
ABSTRACT First described by Retzius at the end of the 19th century, the structure in the posterior medulla oblongata, then named area postrema, underwent an intense investigation into its function in the decades that followed. Findings, mainly in animal studies, have partially elucidated its role as an emetic center in the central nervous system. In the second half of the 20th century, this function was associated with reports of syndromes characterized by uncontrollable nausea and vomiting related to structural damage in the area postrema, mainly in the context of demyelinating diseases. At the beginning of the 21st centu...
Source: Arquivos de Neuro-Psiquiatria - March 9, 2020 Category: Neurology Source Type: research
Arquivos 2020
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Association between cognitive impairment and criteria for frailty syndrome among older adults
Conclusion: Older adults with frailty have a greater likelihood of concomitant cognitive impairment than prefrail and robust older adults. The prevalence of cognitive impairment and frailty is consistent with data reported in literature. The present findings contribute to the investigation of cognitive frailty.Resumo A associa ção entre comprometimento cognitivo e fragilidade tem sida estudada em idosos e os critérios de fragilidade e níveis de fragilidade podem também apresentar influência na função cognitiva. Objetivo: Analisar a associação entre comprometimento cognitivo e os critérios de fragilidade em id os...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Clinical performance of fixed-pressure Sphera Duo® hydrocephalus shunt
Conclusion: Sphera Duo® shunt system is safe when used in adult patients suffering from hydrocephalus, pseudotumor cere bri or arachnoid cyst.Resumo Introdu ção: As complicações da hidrodinâmica cerebral em pacientes com derivação ventriculoperitoneal são frequentemente relacionadas ao malfuncionamento do sistema. O objetivo deste estudo retrospectivo de coorte de centro único é avaliar a segurança e performance clínica do Sistema Sphera® Duo quando utilizado em adultos com hidrocefalia, pseudotumor cerebral ou cistos aracnoides. Métodos: Avaliamos os prontuários de 112 pacientes adultos submetidos a cirurg...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Feasibility of a Brazilian samba protocol for patients with Parkinson's disease: a clinical non-randomized study
Conclusion: The samba protocol seems to be feasible and saf e for patients with PD. Moreover, it has pleasant characteristics and offers sufficient physical benefits for combination with drug treatment. There were also benefits in social relationships and as a possible rehabilitation tool in individuals with Parkinson's disease.Resumo Fundamentos: Novos protocolos aplicados na reabilita ção da doença de Parkinson possibilitam diferentes estratégias de atuação para profissionais de saúde, além de um novo leque de atividades para estes indivíduos. Entretanto, não se encontrou na literatura qualquer protocolo de sam...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Spinal protein kinase A and phosphorylated extracellular signal-regulated kinase signaling are involved in the antinociceptive effect of phytohormone abscisic acid in rats
Conclusions: Overall, i.t. administration of ABA (10 µg/rat) induced analgesia and p-ERK down-expression likely by involving the PKA-dependent mechanism.Resumo Objetivo: O ácido fito-hormônio abscísico (ABA) existe como molécula sinalizadora em vários tipos de organismos, de multicelulares a células e tecidos animais. Foi demonstrado que o ABA tem efeito antinociceptivo em roedores. O presente estudo foi desenhado para avaliar o possível papel da PKA e da ERK f osforilada (p-ERK) nos efeitos antinociceptivos do ABA intratecal (i.t.) em ratos Wistar machos. Métodos: Os animais foram canulados por via i.t. e dividid...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
Resolution of headache after reduction of prolactin levels in hyperprolactinemic patients
Conclusion: Data allow us to conclude that, in this series, in the majority of cases the reduction in the level of PRL was followe3d by cessation or relief of the pain.Resumo Os adenomas secretores de prolactina (PRL) est ão associados à alta incidência de cefaleia. O papel da hiperprolactinemia no contexto da dor de cabeça não está claro, nem o efeito da redução dos níveis da PRL na cefaleia. Métodos: O presente estudo longitudinal avaliou pacientes hiperprolactinêmicos (69), quanto à presença e às c aracterísticas da cefaleia antes e após o tratamento da hiperprolactinemia. Resultados: Cefaleia foi relata...
Source: Arquivos de Neuro-Psiquiatria - February 14, 2020 Category: Neurology Source Type: research
