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Infectious Disease: Tuberculosis

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Total 20273 results found since Jan 2013.

The QuantiFERON-TB Gold In-Tube Assay in Neuro-Ophthalmology
Conclusions: Based on our results, we conclude that routine testing with QFT-GIT in a low-risk cohort did not diagnose active TB infection. We do not recommend routine QFT-GIT testing for TB low-risk individuals, as discerned through patient and exposure history, ocular examination, and clinical judgment, in neuro-ophthalmology practice.
Source: Journal of Neuro-Ophthalmology - August 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum
In this study, a 35-year-old Indian man with an undiagnosed progressive axial spondyloarthropathy (i.e., AS) is reported presenting with acute-onset longitudinally extensive transverse myelitis, a clinical subset of NMOSD. Neuromyelitis optica spectrum disorder (NMOSD), a primary demyelinating disorder of the central nervous system (CNS), is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels, which manifests with optic neuritis, longitudinally extensive transverse myelitis (LETM), area-postrema syndrome, brainstem syndrome diencephalic syndrome, and cerebral syndrome.1-4 Ankylosing spo...
Source: Herpes - July 22, 2022 Category: Infectious Diseases Authors: Ritwik Ghosh Md Devlina Roy Mois és León-Ruiz Shambaditya Das Souvik Dubey Juli án Benito-León Source Type: research

Neurosarcoidosis: Diagnostic Challenges and Mimics A Review
AbstractPurpose of ReviewNeurosarcoidosis is a rare manifestation of sarcoidosis that is challenging to diagnose. Biopsy confirmation of granulomas is not sufficient, as other granulomatous diseases can present similarly. This review is intended to guide the clinician in identifying key conditions to exclude prior to concluding a diagnosis of neurosarcoidosis.Recent FindingsAlthough new biomarkers are being studied, there are no reliable tests for neurosarcoidosis. Advances in serum testing and imaging have improved the diagnosis for key mimics of neurosarcoidosis in certain clinical scenarios, but biopsy remains an import...
Source: Current Allergy and Asthma Reports - May 31, 2023 Category: Allergy & Immunology Source Type: research

Isolated neurosarcoidosis mimicking multifocal meningiomas: a diagnosis pitfall: A case report
Conclusion: The diagnosis of isolated central nervous system sarcoidosis was still difficult because of limitations of available diagnostic tests. So neurosarcoidosis in the clinical work should never be neglected.
Source: Medicine - November 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Teaching NeuroImages: Diffuse cerebral neurosarcoidosis mimicking gliomatosis cerebri
A 30-year-old man with a history of bipolar disease presented with 6 months of cognitive decline, unsteady gait, urinary retention, and bilateral upper extremity tremors. Multiple punctate enhancing lesions were seen on brain MRI (figure). Differential diagnosis included infection (viral, tuberculosis, or cryptococcus), toxic leukoencephalopathy, gliomatosis cerebri, angiocentric lymphoma, and neurosarcoidosis. CT chest scan, CSF studies, HIV testing, hepatitis panel, drug screen, and vasculitis panel were negative. Brain biopsy revealed neurosarcoidosis. The patient responded well to high-dose steroids and IV cyclophospha...
Source: Neurology - August 12, 2013 Category: Neurology Authors: Ramanathan, R. S., Malhotra, K., Scott, T. Tags: RESIDENT AND FELLOW SECTION Source Type: research

Tuberculous perihepatic abscess and neurosarcoidosis: report  of 2 uncommon manifestations of 2 common granulomatous diseases in 1 patient.
We report the case of a 50-year-old Indian man presenting with a tuberculous perihepatic abscess and a systemic inflammatory response after being diagnosed with neurosarcoidosis presenting as a single granuloma in the frontal lobe with lymphadenopathy in 2014. On day of admission the patient presented with right upper abdominal pain and fever for two weeks. With increased inflammatory parameters in serum and after finding of external CT images, a perihepatic abscess was suspected. This encapsulated cave was drained percutaneously under CT control. A high concentration of acid-fast rods was detected using ZN, PCR was positi...
Source: Zeitschrift fur Gastroenterologie - January 1, 2021 Category: Gastroenterology Authors: Gernert JA, Sirtl S, Macke L, Wittmann E, Strueven AK, Schwarze V, Dichtl K, Neumann J, Mayerle J, Schulz C Tags: Z Gastroenterol Source Type: research

Neuro-otologic manifestations of tuberculosis. "The great imitator"
Conclusions Tuberculosis has a wide variety of neurotologic characteristic manifestations from chronic otitis media cadres to vestibular, audiological and neurological manifestations uncertain as well as a large variability in imaging studies
Source: American Journal of Otolaryngology - January 31, 2015 Category: Endocrinology Source Type: research

Neuro-otologic manifestations of tuberculosis. “The great imitator"
Conclusions Tuberculosis has a wide variety of neurotologic manifestations from chronic otitis media cadres to vestibular, audiological and neurological manifestations as well as a large variability in imaging studies.
Source: American Journal of Otolaryngology - May 2, 2015 Category: Endocrinology Source Type: research

Neuro-Sweet disease with positive modified acid-fast staining of the cerebrospinal fluid: A case report.
Authors: Liu JF, Li Y, Li K, Zhang X, Yang YN, Zhao G, Liu ZR Abstract Neuro-Sweet disease (NSD) is Sweet disease with central nervous system (CNS) involvement. To the best of our knowledge, the present case report is the first to describe NSD complicated by endogenous infection with Mycobacterium tuberculosis. The present case report describes a male patient who developed NSD-induced meningitis, which initially manifested as a fever, headache and neck stiffness. Painful erythematous plaques subsequently developed on his face, neck and upper trunk. Brain magnetic resonance imaging was performed and the results were...
Source: Experimental and Therapeutic Medicine - April 15, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Cerebral salt wasting in pediatric critical care; not just a neurosurgical disorder anymore.
CONCLUSION: Cerebral salt-wasting syndrome is increasingly described in the etiology of hyponatremia that is commonly seen in children hospitalized especially at critical care units. Serum sodium, urinary sodium and polyuria should be primarily considered in the diagnosis, and supportive laboratory tests such as uric acid and brain natriuretic peptide (BNP) should not be stipulated. At hospitals providing inpatient care services, clinical and laboratory characteristics of CSWS should be known in detail especially at pediatric critical care units. PMID: 26812288 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - January 28, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Management in primary health care: discourses about the search for respiratory symptomatics of tuberculosis
ABSTRACT The study aimed to analyze the discourse of Primary Health Care managers about the search for respiratory symptomatics as an epidemiological surveillance action of tuberculosis. A qualitative study was undertaken, guided by the theoretical and analytical framework of French Discourse Analysis. Data were produced in May 2012 through semi-structured interviews with 14 subjects. Two discursive blocks were produced: marks of power in the execution of the search for respiratory symptomatics; resistance strategies in the search for respiratory symptomatics. Discursive positions were grounded in the traditional managemen...
Source: Texto e Contexto - Enfermagem - October 3, 2016 Category: Global & Universal Source Type: research

WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships
Publication date: Available online 19 September 2014 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Roopa Ramamoorthi , Katy M. Graef , Jennifer Dent Neglected tropical diseases (NTDs), malaria, and tuberculosis have a devastating effect on an estimated 1.6billion people worldwide. The World Intellectual Property Organization (WIPO) Re:Search consortium accelerates the development of new drugs, vaccines, and diagnostics for these diseases by connecting the assets and resources of pharmaceutical companies, such as compound libraries and expertise, to academic or nonprofit researchers w...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 12, 2014 Category: Parasitology Source Type: research

The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player
The 1940s and 1950s witnessed a diverse search for not just natural product antibiotics but also for synthetic and semisynthetic compounds. This review revisits this epoch, using the research by a Danish pharmaceutical company, LEO Pharma, as an example. LEO adopted a strategy searching for synthetic antibiotics toward specific bacterial pathogens, in particular Mycobacterium tuberculosis, leading to the discovery of a new derivative of a known drug. Work on penicillin during and after WWII lead to the development of associated salts/esters and a search for new natural product antibiotics. This led initially to no new, mar...
Source: Frontiers in Microbiology - June 11, 2020 Category: Microbiology Source Type: research

EDITORIAL:New Developments In The Search For Agents To Treat Tuberculosis.
PMID: 24111910 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - October 10, 2013 Category: Chemistry Authors: Boechat N Tags: Curr Top Med Chem Source Type: research