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Cognitive Impairment Associated with Cancer: A Brief Review
CONCLUSION
Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research
Lactoferrin for Mental Health: Neuro-Redox Regulation and Neuroprotective Effects across the Blood-Brain Barrier with Special Reference to Neuro-COVID-19
J Diet Suppl. 2021 May 12:1-35. doi: 10.1080/19390211.2021.1922567. Online ahead of print.ABSTRACTOverall mental health depends in part on the blood-brain barrier, which regulates nutrient transfer in-and-out of the brain and its central nervous system. Lactoferrin, an innate metal-transport protein, synthesized in the substantia nigra, particularly in dopaminergic neurons and activated microglia is vital for brain physiology. Lactoferrin rapidly crosses the blood-brain barrier via receptor-mediated transcytosis and accumulates in the brain capillary endothelial cells. Lactoferrin receptors are additionally present on glio...
Source: Journal of Dietary Supplements - May 12, 2021 Category: Nutrition Authors: Sreus A G Naidu Taylor C Wallace Kelvin J A Davies A Satyanarayan Naidu Source Type: research
Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia
Publication date: July 2018 Source:Neurochemistry International, Volume 117 Author(s): Shannon Chiang, Danuta S. Kalinowski, Patric J. Jansson, Des R. Richardson, Michael L.-H. Huang Mitochondrial homeostasis is essential for maintaining healthy cellular function and survival. The detrimental involvement of mitochondrial dysfunction in neuro-degenerative diseases has recently been highlighted in human conditions, such as Parkinson's, Alzheimer's and Huntington's disease. Friedreich's ataxia (FA) is another neuro-degenerative, but also cardio-degenerative condition, where mitochondrial dysfunction plays a crucial role in d...
Source: Neurochemistry International - June 14, 2018 Category: Neuroscience Source Type: research
Direct red 89 dye degradation by advanced oxidation process using sulfite and zero valent under ultraviolet irradiation: Toxicity assessment and adaptive neuro-fuzzy inference systems modeling
Environ Res. 2022 Mar 4:113059. doi: 10.1016/j.envres.2022.113059. Online ahead of print.ABSTRACTSulfate-based advanced oxidation process mediated by zero-valent iron (ZVI) and ultraviolet radiation for the decomposition of sulfite salts resulted in the formation of strong oxidizing species (sulfate and hydroxide radicals) in aqueous solution is reported. Degradation of direct red 89 (DR89) dye via UV/ZVI/sulfite process was systematically investigated to evaluate the effect of pH, ZVI dose, sulfite, initial DR89 concentration, and reaction time on DR89 degradation. The synergy factor of UV/ZVI/sulfite process was found to...
Source: Environmental Research - March 8, 2022 Category: Environmental Health Authors: Sara Mahmoudi Saeid Fadaei Ensiyeh Taheri Ali Fatehizadeh Tejraj M Aminabhavi Source Type: research
Clinical delineation of GTPBP2-associated neuro-ectodermal syndrome: Report of two new families and review of the literature.
This article is protected by copyright. All rights reserved.
PMID: 30790272 [PubMed - as supplied by publisher]
Source: Clinical Genetics - February 20, 2019 Category: Genetics & Stem Cells Authors: Carter MT, Venkateswaran S, Shapira-Zaltsberg G, Davila J, Humphreys P, Care4Rare Canada Consortium, Kernohan KD, Boycott KM Tags: Clin Genet Source Type: research
Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor
Publication date: Available online 9 December 2019Source: Neuroscience LettersAuthor(s): Yun-Jin Chen, Zhong-Ming Qian, Yuan Sheng, Jie Zheng, Yong LiuAbstractAngiotensin II (ANGII) modulates expression of iron intake and export proteins in cultured neurons. However, the relevant mechanisms have not been fully elucidated. Here, we investigated the effects of ANGII and/or candesartan, a ANGII-Type-1 Receptor (AT1R) antagonist, and PD123319, a ANGII-Type-2 Receptor (AT2R) antagonist on expression of transferrin receptor 1 (TfR1), ferroportin 1 (Fpn1)and ferritin as well as iron regulatory proteins (IRPs), hepcidin and nuclea...
Source: Neuroscience Letters - December 10, 2019 Category: Neuroscience Source Type: research
