Filtered By:
Nutrition: Sodium
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 37278 results found since Jan 2013.
State-Dependent Inhibition of Voltage-Gated Sodium Channels in Neuroblastoma Neuro-2A Cells by Arachidonic Acid from < em > Halichondria okadai < /em >
This study aimed to identify Nav inhibitors from two snake venoms and H. okadai using mouse neuroblastoma Neuro-2A cells (N2A), which primarily express the specific Nav subtype Nav1.7, using whole-cell patch-clamp recordings. We successfully isolated arachidonic acid (AA, 1) from the hexane extract of H. okadai, and then the fatty acid-mediated modulation of Nav in N2A was investigated in detail for the first time. Octanoic acid (2), palmitic acid (3), and oleic acid (4) showed no inhibitory activity at 100 μM, whereas AA (1), dihomo-γ-linolenic acid (DGLA, 5), and eicosapentaenoic acid (EPA, 6) showed IC50 values of 6.1...
Source: Cell Research - October 31, 2022 Category: Cytology Authors: Osamu Chiba Noriko Shimada Shutaro Yoshio Yuta Kudo Yuko Cho Mari Yotsu-Yamashita Keiichi Konoki Source Type: research
Detection of a nonerythropoietic erythropoietin, Neuro ‐EPO, in blood after intranasal administration in rat
Neuro ‐EPO is a new nonerythropoietic drug investigated to treat brain diseases. Neuro‐EPO migrates in the same area as endogenous EPO by SDS‐PAGE. Neuro‐EPO can be identified by IEF using a 2–10 pH gradient. Neuro‐EPO can be detected in plasma from 2 to 48‐h post‐intranasal administration . AbstractNonerythropoietic erythropoietins (EPOs) are investigated for their high antioxidant properties. A new drug candidate under clinical investigation to treat brain diseases is Neuro ‐EPO, produced by selecting EPO isoforms with low sialic acid content. Intranasal administration allows to bypass the blood–brain...
Source: Drug Testing and Analysis - September 8, 2020 Category: Drugs & Pharmacology Authors: Laurent Martin,
Julio Cesar Garcia Rodriguez,
Michel Audran,
Magnus Ericsson,
Tangui Maurice,
Alexandre Marchand Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
Perspectives of X-nuclei magnetic resonance imaging in neuro-oncology.
CONCLUSIONS: X‑nuclei MRI is a rapidly evolving field in metabolic and functional imaging. In coming years, sodium MRI is expected to be increasingly used as an additional clinical tool in oncology to enhance diagnostic accuracy.
PMID: 33025136 [PubMed - as supplied by publisher]
Source: Der Radiologe - October 6, 2020 Category: Radiology Authors: Regnery S, Platt T Tags: Radiologe Source Type: research
Intensity-dependent mass search for improving metabolite database matches in chemical isotope labeling LC-QTOF-MS-based metabolomics
Anal Chim Acta. 2023 Sep 1;1272:341467. doi: 10.1016/j.aca.2023.341467. Epub 2023 Jun 1.ABSTRACTLiquid chromatography mass spectrometry (LC-MS) has been increasingly used for metabolome analysis. One of the critical steps in the LC-MS metabolome analysis workflow is related to metabolite identification. Among the measured parameters, peak mass is commonly used to search against a database for potential metabolite matches. Higher accuracy mass measurement allows the use of a narrower mass tolerance window for mass search. While various types of mass analyzers can routinely measure a peak mass with an error of less than a fe...
Source: Analytica Chimica Acta - June 24, 2023 Category: Chemistry Authors: Yunong Li Hao Li Taibo Luo Guohui Lin Liang Li Source Type: research
HBK-14 and HBK-15, triple 5-HT1A, 5-HT7 and 5-HT3 antagonists with potent antidepressant- and anxiolytic-like properties, increase seizure threshold in various seizure tests in mice
Publication date: 3 October 2017 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 79, Part B Author(s): Karolina Pytka, Katarzyna Socała, Anna Rapacz, Dorota Nieoczym, Mateusz Pieróg, Anna Gryboś, Agata Siwek, Anna Waszkielwicz, Piotr Wlaź Most antidepressants lower seizure threshold, which might be due to the modulation of serotonergic neurotransmission. Here, we investigated the effects of two 5-HT1A, 5-HT7 and 5-HT3 antagonists, i.e., 1-(2-(2-(2,6-dimethylphenoxy)ethoxy)ethyl)-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-14) and 1-{2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl}-4-(2-m...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 26, 2017 Category: Psychiatry Source Type: research
