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Neurosarcoidosis and Ocular Inflammation: A Case Series and Literature Review
Conclusion: NS is an uncommon, but potentially life-threatening, manifestation of sarcoidosis with ocular involvement up to 25% of patients. Patients presenting with neuro-ophthalmic manifestations of sarcoidosis are more likely to have other sites of involvement requiring ophthalmologists to maintain a high index of suspicion for systemic disease.
Source: Journal of Neuro-Ophthalmology - June 1, 2021 Category: Opthalmology Tags: Trainees' Corner Source Type: research

Obstructive Sleep Apnea in Neuro-Ophthalmology
Conclusions: OSA is associated with many diseases seen in neuro-ophthalmology clinics. More studies are required to assess the real ability of CPAP to reverse pathological changes. Ophthalmologists can screen for undiagnosed OSA in patients presenting with certain eye diseases.
Source: Journal of Neuro-Ophthalmology - August 30, 2019 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Secondary Stroke Prevention and Management for the Neuro-Ophthalmologist
Conclusions: The optimal treatment to prevent stroke recurrence is determined by the etiology of stroke. After stroke workup, patients will typically be placed on proper medical therapy for the appropriate duration in addition to counseling on lifestyle modifications to reduce the risk of recurrent strokes. For complex patients, it is reasonable for providers to consider patient referral to stroke specialists for further aid in selection of appropriate medical therapy.
Source: Journal of Neuro-Ophthalmology - November 22, 2020 Category: Opthalmology Tags: Disease of the Year 2020: Cerebrovascular Disorders Source Type: research

Neuro-protection and neuro-regeneration of the optic nerve: recent advances and future directions
Purpose of review Optic neuropathies refer to a collection of diseases in which retinal ganglion cells (RGCs), the specialized neuron of the retina whose axons make up the optic nerve, are selectively damaged. Blindness secondary to optic neuropathies is irreversible as RGCs do not have the capacity for self-renewal and have a limited capacity for self-repair. Numerous strategies are being developed to either prevent further RGC degeneration or replace the cells that have degenerated. In this review, we aim to discuss known limitations to regeneration in central nervous system (CNS), followed by a discussion of previous,...
Source: Current Opinion in Neurology - January 17, 2020 Category: Neurology Tags: NEURO-OPHTHALMOLOGY: Edited by Heather E. Moss Source Type: research

Neuro-Ophthalmic Phenotype of OPA3
Conclusions: This study compiled data regarding neuro-ophthalmic manifestation of OPA 3 Type III patients. Contrary to established literature, poor vision was the presenting symptom in only 50% of our patients. This is the first report of OCT findings in 3MGA patients. The results demonstrated diffused thinning of the RNFL and ganglion cell complex-IPL with correlation to VA, which is in contrast to OPA1 patients in whom the most severe thinning is at the level of the papillomacular bundle. Average retinal thinning was identified at second and third decades of life, possibly resulting from early ganglion cell loss. The...
Source: Journal of Neuro-Ophthalmology - February 25, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research

The use of optical coherence tomography in neuro-ophthalmology
Purpose of review In the last decade, with the advances of optical coherence tomography (OCT) technology, different imaging protocols and analysis algorithms have been introduced to maximize the potential of this diagnostic tool in the evaluation of different eye diseases. This review aims to provide an update on these additional features, with respect to the management of a diverse range of neuro-ophthalmologic conditions. Recent findings Macular ganglion cell complex (mGCC) analysis has been shown to be superior to peripapillary retinal nerve fiber layer (pRNFL) analysis in certain settings, such as differentiating Lebe...
Source: Current Opinion in Ophthalmology - October 12, 2017 Category: Opthalmology Tags: NEURO-OPHTHALMOLOGY: Edited by Dean M. Cestari Source Type: research

An atypical case of neurosarcoidosis presenting with neovascular glaucoma
ConclusionsA patient with neurosarcoidosis presenting with compressive ischemic optic disc edema and neovascular glaucoma is described, increasing the diversity of clinical presentations and confirming the diagnostic challenge of neurosarcoidosis.
Source: Journal of Ophthalmic Inflammation and Infection - April 18, 2018 Category: Opthalmology Source Type: research

Neurosarcoidosis presenting as CRVO combined CRAO: a biopsy-proven case report of a Chinese patient
Neurosarcoidosis is a rare systemic disorder that can affect the eye and other organs, including the central nervous system. Neurosarcoidosis infiltrating the optic nerve presenting as central retinal vein occ...
Source: BMC Ophthalmology - August 27, 2020 Category: Opthalmology Authors: Chaoyi Feng, Qian Chen, Wei Liu, Yingwen Bi, Jiang Qian, Min Wang, Xinghuai Sun and Guohong Tian Tags: Case report Source Type: research

Evolution of Visual Outcomes in Clinical Trials for Multiple Sclerosis Disease-Modifying Therapies
Conclusions: Visual impairment represents a significant component of overall disability in MS. LCLA and OCT enhance the detection of visual pathway injury and can be used as measures of axonal and neuronal integrity. Continued investigation is ongoing to further incorporate these vision-based assessments into clinical trials of MS therapies.
Source: Journal of Neuro-Ophthalmology - May 18, 2018 Category: Opthalmology Tags: Disease of the Year: Multiple Sclerosis Source Type: research

Clinical Role of Smartphone Fundus Imaging in Diabetic Retinopathy and Other Neuro-retinal Diseases
Conclusions: To conclude, smartphone imaging can now be considered as a quick, cost-effective, and digitalized tool for posterior segment screenings, however, their definite role in routine ophthalmic clinics is yet to be established.PMID:34325587 | DOI:10.1080/02713683.2021.1958347
Source: Current Eye Research - July 30, 2021 Category: Opthalmology Authors: Amar Pujari Gunjan Saluja Divya Agarwal Ayushi Sinha Ananya P R Atul Kumar Namrata Sharma Source Type: research

Neuro-ophthalmic complications of varicella-zoster virus
Curr Opin Ophthalmol. 2023 Aug 22. doi: 10.1097/ICU.0000000000000996. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review broadly describes recent neuro-ophthalmic manifestations of varicella-zoster virus (VZV) reported in literature.RECENT FINDINGS: Despite varicella vaccination, the incidence of herpes zoster continues to rise, potentially leading to devastating consequences when ocular complications occur.A small but growing literature documents cases of retinal disease because of varicella reactivation after SARS-CoV-2 vaccination, ischemic optic neuropathy occurring during herpes zoster ophthalmicus, VZV-indu...
Source: Herpes - August 21, 2023 Category: Infectious Diseases Authors: Toluwalase O Tofade Bart K Chwalisz Source Type: research

Neuro-ophthalmic Disease in Pediatric Glaucoma Practice
Precis: Pediatric glaucoma referral to neuro-ophthalmology has a high yield for diagnosing neurological disease and neuroimaging in this cohort often uncovers intracranial abnormalities. Purpose: Multiple studies have examined the utility of neuro-ophthalmology referrals in an adult glaucoma patient population. No similar studies in the pediatric glaucoma population have been completed. An analysis of pediatric referral patterns and clinical characteristics can serve to guide future physician referrals and improve patient outcomes. Materials and Methods: A retrospective review of medical records was conducted to id...
Source: Journal of Glaucoma - January 30, 2020 Category: Opthalmology Tags: Original Studies Source Type: research