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Total 18140 results found since Jan 2013.

Nutrition and neurodevelopment: the search for candidate nutrients in the Seychelles Child Development Nutrition Study
Neurotoxicology. 2020 Dec;81:300-306. doi: 10.1016/j.neuro.2020.09.021. Epub 2020 Oct 14.ABSTRACTThis review examines the role of nutrients in child development and outlines the key nutrients identified as potentially important to neurodevelopment among high fish consumers in the Seychelles Child Development Nutrition Study (SCDNS). It describes the clinical assessment of these nutrients in the blood and breast milk samples collected from the cohort of 300 pregnant women who were recruited, at their first antenatal visit, on the SCDNS. These key nutrients include the long chain polyunsaturated fatty acids (LCPUFA), docosoh...
Source: Neurotoxicology - March 20, 2021 Category: Neurology Authors: J J Strain Maxine P Bonham Emeir M Duffy Julie M W Wallace Paula J Robson Thomas W Clarkson Conrad Shamlaye Source Type: research

Zinc oxide nanoparticles and L-carnitine effects on neuro-schistosomiasis mansoni induced in mice.
Abstract Neuro-schistosomiasis can induce neurological symptoms and severe disability. Since the resistance against the chemotherapy "praziquantel" was reported, the aim of the present study was investigating the anti-neuro-schistosomal effects of ZnO nanoparticles and/or L-carnitine (as free radicals scavenger) on schistosome-infected mice, where technology of nanoparticles has come to the forefront in the medical diagnosis and therapeutic drug delivery. In the human body, nanoscale-sized particles can move freely and reveal unique biological, mechanical, electrical, and chemical properties. In the present study,...
Source: Environmental Science and Pollution Research International - March 22, 2020 Category: Environmental Health Authors: Bauomy AA Tags: Environ Sci Pollut Res Int Source Type: research

Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats
We evaluated the neuro-, immuno-, and male reproductive toxicity of zinc oxide nanoparticles (ZnO NPs) alone and in combination with lead acetate. We also studied the therapeutic role of α-lipoic acid postexposure. Lead (10 mg/kg, body weight), ZnO NPs (100 mg/kg, bwt) alone, and their combination were administered orally in Wistar rats for 28 days, followed by the administration of α-lipoic acid (15 mg/kg, bwt) for the next 15 days. Our results demonstrated protective effects of α-lipoic acid on lead and ZnO NP–induced biochemical alterations in neurological, immunological, and male reproductive organs in rats. ...
Source: Frontiers in Pharmacology - July 8, 2021 Category: Drugs & Pharmacology Source Type: research

Late onset Wilson Disease with normal neuro-psychiatric status: A case report
CONCLUSIONS: In spite of being uncommon in later age, WD and its different variations like with normal neuro-psychiatric status should be considered as an etiology in cases of unexplained liver diseases.PMID:35638048 | PMC:PMC9142667 | DOI:10.1016/j.amsu.2022.103678
Source: Annals of Medicine - May 31, 2022 Category: Internal Medicine Authors: Bishal Dhakal K C Prabhat Abinash Karki Ayush Mohan Bhattarai Sachin Sapkota Binaya Subedi Abhinav Dahal Source Type: research

Zinc deficiency in rats is associated with up-regulation of hippocampal NMDA receptor
Conclusions The procedure of zinc restriction in rats causes behavioral changes that share some similarities to the pathophysiology of depression. Obtained data indicated that depressive-like behavior induced by zinc deficiency is associated with the changes in NMDAR signaling pathway. Graphical abstract
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 6, 2014 Category: Psychiatry Source Type: research

Zinc in drug-naïve patients with short-illness-duration first episode major depressive disorder: impact on psychopathological features.
CONCLUSION: The study provides evidence for unchanged plasma zinc concentration at early stage of MDD and failed to demonstrate any correlation between plasma zinc and psychopathological features including severity of symptoms and specific psychopathological dimensions in MDD. PMID: 25702304 [PubMed - indexed for MEDLINE]
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants
Conclusions Contrary to some – but not all – previous findings, this study of a large sample of schizophrenia cases and healthy controls reveals no evidence for association between grey matter alterations and variation in rs1344706 (ZNF804A). Differences in sample sizes and ethnicities may account for discrepant findings between the present and previous studies.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 6, 2018 Category: Psychiatry Source Type: research

Zinc as a therapy in a rat model of autism prenatally induced by valproic acid
Publication date: 8 June 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 84, Part A Author(s): Luana Carvalho Cezar, Thiago Berti Kirsten, Caio Cesar Navarrete da Fonseca, Ana Paula Nascimento de Lima, Maria Martha Bernardi, Luciano Freitas Felicio Autism is characterized by numerous behavioral impairments, such as in communication, socialization and cognition. Recent studies have suggested that valproic acid (VPA), an anti-epileptic drug with teratogenic activity, is related to autism. In rodents, VPA exposure during pregnancy induces autistic-like effects. Exposure to VPA may alter zin...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 4, 2018 Category: Psychiatry Source Type: research

Can we predict treatment response in children with ADHD to a vitamin-mineral supplement? An investigation into pre-treatment nutrient serum levels, MTHFR status, clinical correlates and demographic variables
ConclusionsThis study replicates Rucklidge et al.(Rucklidge et al., 2014b) showing the limited value of using serum nutrient levels to predict treatment response although we cannot rule out that other non-assayed nutrient levels may be more valuable. Additionally, no specific demographic or clinical characteristics, including MTHFR genetic status, were identified that would preclude children with ADHD from trying this treatment approach.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - September 12, 2018 Category: Psychiatry Source Type: research

Potential of the multivitamin-mineral-trace element composition LaVita ® before, during and after pregnancy.
CONCLUSION: The regular intake filled up the respective storage compartments and reservoirs in the tissues, and improved the metabolic status. Female participants tended to benefit more than male. We conclude that the composition is safe, and warrants optimized micronutrient supply during pregnancy or postnatal breastfeeding. PMID: 30860682 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - March 14, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Serum copper and zinc levels correlate with biochemical metabolite ratios in the prefrontal cortex and lentiform nucleus of patients with major depressive disorder
ConclusionOur findings suggest that higher serum copper and lower serum zinc levels may contribute to neuronal impairment by affecting neuronal biochemical metabolite ratios in the right PFC and right LN of MDD patients. Abnormal copper and zinc levels may play an important role in the pathophysiology of MDD.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 26, 2019 Category: Psychiatry Source Type: research

Anorexia nervosa, zinc deficiency and the glutamate system: The ketamine option
Publication date: Available online 10 March 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Daniel F. Hermens, Gabrielle Simcock, Megan Dutton, Ana P. Bouças, Adem T. Can, Chris Lilley, Jim Lagopoulos
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - March 11, 2020 Category: Psychiatry Source Type: research

Molecules, Vol. 23, Pages 1876: Be Aware of Aggregators in the Search for Potential Human ecto-5 ′-Nucleotidase Inhibitors
Molecules, Vol. 23, Pages 1876: Be Aware of Aggregators in the Search for Potential Human ecto-5′-Nucleotidase Inhibitors Molecules doi: 10.3390/molecules23081876 Authors: Lucas G. Viviani Erika Piccirillo Arquimedes Cheffer Leandro de Rezende Henning Ulrich Ana Maria Carmona-Ribeiro Antonia T.-do Amaral Promiscuous inhibition due to aggregate formation has been recognized as a major concern in drug discovery campaigns. Here, we report some aggregators identified in a virtual screening (VS) protocol to search for inhibitors of human ecto-5′-nucleotidase (ecto-5′-NT/CD73), a...
Source: Molecules - July 27, 2018 Category: Chemistry Authors: Lucas G. Viviani Erika Piccirillo Arquimedes Cheffer Leandro de Rezende Henning Ulrich Ana Maria Carmona-Ribeiro Antonia T.-do Amaral Tags: Article Source Type: research

Molecules, Vol. 24, Pages 446: Novel Approach for the Search for Chemical Scaffolds with Dual Activity with Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor—A Perspective for the Treatment of Neurodegenerative Disorders
homas Balle Neurodegenerative disorders, including Alzheimer’s disease, belong to the group of the most difficult and challenging conditions with very limited treatment options. Attempts to find new drugs in most cases fail at the clinical stage. New tactics to develop better drug candidates to manage these diseases are urgently needed. It is evident that better understanding of the neurodegeneration process is required and targeting multiple receptors may be essential. Herein, we present a novel approach, searching for dual active compounds interacting with acetylcholinesterase (AChE) and the &al...
Source: Molecules - January 27, 2019 Category: Chemistry Authors: Natalia M. Kowal Dinesh C. Indurthi Philip K. Ahring Mary Chebib Elin S. Olafsdottir Thomas Balle Tags: Article Source Type: research