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Total 24287 results found since Jan 2013.

Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions
ConclusionCompounds of high interest as potential antihyperalgesic agents are: curcumin, resveratrol, capsaicin, quercetin, eugenol, naringenin and epigallocatechin gallate (EGCG). Current knowledge about molecular targets of pain and their regulation by these phytochemicals is elaborated and the scope of further research is discussed.
Source: Inflammation Research - May 16, 2018 Category: Research Source Type: research

Matrine protects neuro-axon from CNS inflammation-induced injury.
Abstract Neuro-axonal injury in the central nervous system (CNS) is one of the major pathological hallmarks of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has recently been shown to effectively suppress EAE through an anti-inflammatory mechanism. However, whether MAT can also protect myelin/axons from damage is not known. In the present study we show that, while untreated rats developed severe clinical disease, CNS inflammatory demyelination, and axonal damage, these clinical a...
Source: Experimental and Molecular Pathology - January 7, 2015 Category: Pathology Authors: Kan QC, Lv P, Zhang XJ, Xu YM, Zhang GX, Zhu L Tags: Exp Mol Pathol Source Type: research

Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice.
In conclusion, these findings suggest that administration of berberine could prevent depressive-like behaviors in CUMS mice by suppressing neuro-inflammation in the hippocampus. PMID: 28842306 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - August 22, 2017 Category: Neurology Authors: Liu YM, Niu L, Wang LL, Bai L, Fang XY, Li YC, Yi LT Tags: Brain Res Bull Source Type: research

Molecules, Vol. 23, Pages 2920: Mitigation Effects of a Novel Herbal Medicine, Hepad, on Neuroinflammation, Neuroapoptosis, and Neuro-Oxidation
This study also showed that the neuroprotective effects of Hepad include anti-inflammatory, anti-apoptotic, and anti-oxidative properties, in addition to activation of the protein kinase B, extracellular-signal-regulated kinase, and c-Jun N-terminal kinase signaling pathways. Furthermore, oral administration of Hepad 1 and 2 attenuated the death of tyrosine hydroxylase-positive substantia nigra neurons that was induced by 20 mg/kg MPTP. Therefore, our results suggest that Hepad 1 and 2 are useful for treating PD and other disorders associated with neuro-inflammatory, neuro-apoptotic, and neuro-oxidative damage.
Source: Molecules - November 8, 2018 Category: Chemistry Authors: Da Hye Song Gyeong-Ji Kim Kwon Jai Lee Jae Soo Shin Dong-Hee Kim Byung-Jun Park Jeung Hee An Tags: Article Source Type: research

What the ancient Greeks and Romans knew (and did not know) about seasickness
Conclusion: The triggers, symptoms, and preventive measures of seasickness were well-known in antiquity. The implications for transport of troops and military actions were repeatedly described, e.g., by Livius and Caesar. At that time, the pathophysiologic mechanism was explained by the humoral theory of Empedokles and Aristoteles. Seneca Minor localized the bodily symptoms in various organs such as stomach, gullet, and esophagus, and also attributed them to an imbalance of bile. Recommended medication included ingestion of the plant white hellebore, a violent gastrointestinal poison. This remedy contains various alkaloids...
Source: Neurology - February 8, 2016 Category: Neurology Authors: Huppert, D., Oldelehr, H., Krammling, B., Benson, J., Brandt, T. Tags: Clinical neurology history, All Neuro-ophthalmology, All Neurotology, Vertigo, All clinical neurophysiology HISTORICAL NEUROLOGY Source Type: research

Dietary supplementation with Allium hirtifolium and/or Astragalus hamosus improved memory and reduced neuro-inflammation in the rat model of Alzheimer ’s disease
Applied Physiology, Nutrition, and Metabolism, e-First Articles. Allium hirtifolium Boiss and Astragalus hamosus L. are mentioned in Iranian traditional medicine documentation as therapy for a kind of dementia with the features and symptoms similar to those of Alzheimer ’s disease (AD). In the present study, the effects of these herbs on neuro-inflammation and memory have been evaluated as new therapies in amyloid beta (Aβ)-induced memory impairment model. Separate groups of rats were fed with A. hirtifolium or A. hamosus extract (both 100 mg/(kg·day)−1) star ted 1 week before stereotaxic surgery to 24 h before behav...
Source: Applied Physiology, Nutrition, and Metabolism - December 20, 2017 Category: Physiology Authors: Zahra Bahaeddin Asal Yans Fariba Khodagholi Shamim Sahranavard Source Type: research

European medicinal and edible plants associated with subacute and chronic toxicity part II: Plants with hepato-, neuro-, nephro- and immunotoxic effects.
Abstract A tremendous surge of public interest in natural therapies has been reported in the past several decades in both developing and developed countries. Furthermore, edible wild-growing plants whose use had long been associated with poverty and famine have also gained in popularity among people in developed countries. An important fraction of herbal products evade all control measures and are generally perceived as safe. However, this may not always be true. It is important to recognize that some plants are not associated with acute toxicity but rather produce more insidious problems, which develop only with ...
Source: Food and Chemical Toxicology - March 20, 2016 Category: Food Science Authors: Kristanc L, Kreft S Tags: Food Chem Toxicol Source Type: research

Review of Neuro-nutrition Used as Anti-Alzheimer Plant, Spinach, Spinacia oleracea.
The objective of this article was to conduct a review on various ethnomedicinal uses of the spinach and its influences on the pathophysiology of Alzheimer's disease based on a literature review. PMID: 28082792 [PubMed - in process]
Source: Pharmacognosy Reviews - January 15, 2017 Category: Drugs & Pharmacology Tags: Pharmacogn Rev Source Type: research

The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice
In conclusion, these results suggest that the essential oil derived from S. odoratissima produces an anxiolytic-like effect without altering motor performance and that this effect is mediated by 5-HT1A but not via benzodiazepine receptors. In addition, the major component, β-caryophyllene, also has an anxiolytic-like effect that may contribute to the effects of EO, but this effect does not seem to be mediated via 5-HT1A or benzodiazepine receptors. Graphical abstract Highlights ► S. odoratissima essential oil (EO) and β-caryophyllene has anxiolytic-like effect. ► EO or β-caryophyllene does not produce motor impai...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 21, 2014 Category: Psychiatry Source Type: research

Determination of antioxidative properties of herbal extracts: Agrimonia herba, Cynare folium, and Ligustri folium.
Authors: Topolska D, Valachova K, Nagy M, Soltes L Abstract OBJECTIVES: Hyaluronan (HA) molecules were exposed to free radical-mediated degradation performed by the reaction mixture Cu(II) and ascorbate, the so-called Weissberger biogenic oxidative system, which mimics the situation of acute inflammation. To achieve protection of HA from degradation, herbal extracts such as Agrimonia herba, Cynare folium, and Ligustri folium were selected. METHODS: Time- and dose- dependent changes of dynamic viscosity of the HA solutions in the presence and absence of the herbal extracts were recorded by rotational viscometry ...
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Multiple sclerosis in an acupuncture practice.
We present a case of 66-year-old female patient who has been treated by both conventional and Chinese traditional medicine after diagnosis was confirmed in 2008 as MS and antiphospholipid syndrome associated with CNS vasculitis. After diagnosis with clinical image confirmed with CT and MRI scan, where demyelinating zones were present, she started pharmacological therapy without major improvement. Patient suffered with fatigue, walking difficulties, weakness, was unable to articulate due to vocal cords spasms. We started acupuncture treatment in 2010 with herbal supplement therapy as well and patient had in total of 197 se...
Source: Neuroendocrinology Letters - June 27, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

A Chinese herbal medicine (Modified Guomin Decoction) Influences the differentiation of CD4+ T-cell subsets in OVA-induced asthmatic mice.
Authors: Abstract OBJECTIVE: Modified Guomin Decoction (MGD) is an effective Chinese herbal medicine for treatment of various allergic diseases, especially allergic asthma. Its water decoction is conventionally used for treatment of allergic bronchitis in China. Up to date, the underlying mechanisms of this herbal combination have not been fully investigated yet. METHODS: In the in vivo study, the mice were treated with Chicken egg ovalbumin (OVA) and aluminum hydroxide gel as the classic allergic asthma animal model. After treatment with MGD, the lung tissues were examined by Histological assessment. The flow...
Source: Neuroendocrinology Letters - August 2, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

An open prospective pilot study of a herbal combination "Relief" as a supportive dietetic measure during alcohol withdrawal.
CONCLUSIONS: Despite the limitations of the present study, the findings showed the potential of Relief for the improvement of the clinical situation of patients with symptoms of alcohol withdrawal and therefore, justify a full-scale well-controlled study design to be implemented. PMID: 29604618 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - April 3, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Zuoguiwan Ameliorates Cognitive Deficits and Neuro-Inflammation in Streptozotocin-Induced Alzheimer ’s Disease Rats
Conclusion: The results indicated that ZGW might be a novel therapeutic strategy to slow the process of AD by modulating ER β.Neuroimmunomodulation
Source: Neuroimmunomodulation - July 28, 2021 Category: Allergy & Immunology Source Type: research