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Total 38222 results found since Jan 2013.
Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore
ConclusionOur findings suggest that concomitant use of simvastatin with rivaroxaban may be associated with bleeding events in an Asian cohort. Further studies using physiologically based pharmacokinetic modelling are required to investigate the drug-drug interactions between these drugs.
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
NICE moves CVD advice closer to QOF and updates treatment escalation options
NICE draft guidance on cardiovascular disease backs a new target for lipid levels for secondary prevention and offers advice on escalating treatment for people on statins.
Source: GP Online News - September 22, 2023 Category: Primary Care Tags: Clinical News Source Type: news
Influence of non-osteoporotic treatments in patients on active anti-osteoporotic therapy: evidence from the OSTEOMED registry
ConclusionThe potential beneficial or detrimental effects of the different drugs evaluated on fracture risk are masked by treatment with anabolic or antiresorptive drugs that have a more potent action on bone metabolism, with two exceptions: letrozole and oral corticosteroids. These findings may have important clinical implications, as patients receiving these treatments are not fully protected by bisphosphonates, which may imply the need for more potent anti-osteoporotic drugs such as denosumab or teriparatide.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
Acute spinal cord infarction secondary to ankylosing spondylitis: a case report and literature review
ConclusionAlthough this is a rare entity, it is necessary for physicians to consider it when evaluating patients with a sudden loss of sensation and strength in their lower limbs.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research
Atorvastatin vs Aspirin in People With HIV Atorvastatin vs Aspirin in People With HIV
Which of these two drugs are better at reducing HIV-associated inflammation, and in turn, the risk for cardiovascular disease?AIDS
Source: Medscape Hiv-Aids Headlines - September 21, 2023 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news
The effects of statins on the function and differentiation of blood cells
Arch Med Sci. 2022 Dec 25;19(5):1314-1326. doi: 10.5114/aoms/158546. eCollection 2023.ABSTRACTStatins are inhibitors of β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). They are used in patients with cardiovascular risk and/or suffering with cardiovascular disease. In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. Statins also regulate innate and acquired immunity. The focus of this review is to...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Sajjad Chamani Omid Kooshkaki Maryam Moossavi Mandana Rastegar Sara Saffar Soflaei Alice P McCloskey Maciej Banach Amirhossein Sahebkar Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
The effects of statins on the function and differentiation of blood cells
Arch Med Sci. 2022 Dec 25;19(5):1314-1326. doi: 10.5114/aoms/158546. eCollection 2023.ABSTRACTStatins are inhibitors of β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). They are used in patients with cardiovascular risk and/or suffering with cardiovascular disease. In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. Statins also regulate innate and acquired immunity. The focus of this review is to...
Source: Archives of Medical Science - September 21, 2023 Category: General Medicine Authors: Sajjad Chamani Omid Kooshkaki Maryam Moossavi Mandana Rastegar Sara Saffar Soflaei Alice P McCloskey Maciej Banach Amirhossein Sahebkar Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: General Medicine Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
The effects of statins on the function and differentiation of blood cells
Arch Med Sci. 2022 Dec 25;19(5):1314-1326. doi: 10.5114/aoms/158546. eCollection 2023.ABSTRACTStatins are inhibitors of β-hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase (HMGCR). They are used in patients with cardiovascular risk and/or suffering with cardiovascular disease. In addition to their efficient lipid-lowering effects, statins exhibit independent so called pleiotropic effects potentially affecting several immune response properties including immune cell activation, migration, cytokine generation, immune metabolism, and survival. Statins also regulate innate and acquired immunity. The focus of this review is to...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Sajjad Chamani Omid Kooshkaki Maryam Moossavi Mandana Rastegar Sara Saffar Soflaei Alice P McCloskey Maciej Banach Amirhossein Sahebkar Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
Quantifying the impact of taking medicines for primary prevention: a time-trade off study to elicit direct treatment disutility in the UK
Conclusions
Statins and bisphosphonates have a quantifiable DTD. The size of estimated disutilities suggest they are likely to be important for cost-effectiveness, particularly in individuals at low-risk when treated for primary prevention.
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Thompson, A., Youn, J.-H., Guthrie, B., Hainsworth, R., Donnan, P., Rogers, G., Morales, D., Payne, K. Tags: Open access, Health economics Source Type: research
Frequency of lipoprotein(a) measurements in patients with or at risk of cardiovascular disease
Lipoprotein (a) [Lp(a)] is an apolipoprotein B-containing low density lipoprotein with an additional apolipoprotein(a) bound. It is a highly prevalent, genetically determined, biomarker strongly predicting atherosclerotic cardiovascular disease (ASCVD) events and calcific aortic stenosis.1 Lp(a) contributes to cardiovascular disease through pro-atherogenic, pro-inflammatory, and pro-thrombotic effects.2,3 A meta-analysis of statin-treated patients with an elevated baseline and on-statin lipoprotein(a) showed a linear relationship with cardiovascular risk.
Source: Journal of Clinical Lipidology - September 21, 2023 Category: Lipidology Authors: Bhavana Upadhyaya, Ying Wang, Jeffrey Bruckel, Robert C Block Tags: Original Research Source Type: research
Evidence For Underprescription of Guideline-recommended Cardiovascular Medications to Adults With Peripheral Artery Disease: A Systematic Review and Meta-analysis
The aim of this study was to systematically review and meta-analyze the incidence and prevalence of underprescription of antiplatelet, statin, and antihypertensive medications, adjusted risk factors for underprescription, and outcomes associated with underprescription.
Source: Journal of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Maude Paquet, Aidan M. Kirkham, David de Launay, Ian D. Graham, Dean Fergusson, Sudhir K. Nagpal, Risa Shorr, Jeremy M. Grimshaw, Derek J. Roberts Source Type: research
