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Annual Meeting of the North American Neuro-Ophthalmology Society, Puerto Rico, March 1–6, 2014
No abstract available
Source: Journal of Neuro-Ophthalmology - September 1, 2014 Category: Opthalmology Tags: Neuro-Ophthalmology News Source Type: research

Ge-16 * japanese pediatric molecular neuro-oncology group (jpmng): establishment of a nationwide molecular diagnostic network for pediatric malignant brain tumors in japan
Recent intensive molecular biological analyses revealed that pediatric brain tumors can be subclassified into multiple distinct molecular subgroups. The current consensus is that medulloblastomas consist of four core subgroups, and the sub-grouping of ependymomas is being proposed. This molecular sub-grouping system will not only improve our understanding of the biology of these tumors, but may also contribute for the development of novel therapeutic targets and strategies in the future. We have formed the Japanese Pediatric Molecular Neuro-oncology Group (JPMNG) and initiated a new clinical research project to establish a...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Kanemura, Y., Ichimura, K., Shofuda, T., Nishikawa, R., Yamasaki, M., Taylor, M. D., Arai, H., Shibui, S. Tags: GENOMICS AND MOLECULAR PATHOLOGY (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Ni-10 * a mass spectrometry imaging platform to study drug-susceptibility of brain tumors
Brain tumor heterogeneity poses significant challenges to their study and moreover to their treatment. A tool that could characterize a tumor specimen based on its cellular composition and response to treatment could assist the treating neuro-oncologist in determining the optimal treatment. We have developed a chip to culture dissociated cells in an organized array to categorize cell populations and subject them to targeted therapy. The chip was designed for analysis by optical and mass spectrometry imaging. The microwell array coupled to matrix assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) i...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Calligaris, D., Loginov, D., Machaidze, R., Alberta, J. A., Stiles, C. D., Love, J. C., Agar, N. Y. R. Tags: NEURO-IMAGING (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Ni-21 * contrast enhanced t1 subtraction maps improve detection of residual tumor following resection, reduces measurement variability, and predicts survival after anti-angiogenic therapy in glioblastoma
CONCLUSION: T1 subtraction maps improve measurement accuracy and confidence of contrast enhancing tumor burden and should be used for determining extent of resection and response to therapy.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Ellingson, B., Kim, G., Woodworth, D., Pope, W., Nghiemphu, P., Lai, A., Cloughesy, T. Tags: NEURO-IMAGING (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Ni-25 * physiologic imaging in patients with brain metastases; heterogeneity based upon primary tumor subtype
CONCLUSIONS: There was no significant difference in tumor volume based upon tumor type, although there was a trend toward larger tumors at diagnosis for colon and ovarian primaries. There was no significant difference in ADC between tumor type; a significant elevation in rCBV was seen for renal cell and ovarian primary tumors (2.51 and 2.46) when compared with breast, colon, melanoma and lung primary tumors (1.18, 1.24, 1.38, 1.27, respectively). When considering questions of diagnostic specificity, it is important to recognize the relatively low rCBV in many active brain metastases, particularly as compared with primary brain tumors.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Fouke, S., LaMontagne, P., Fontana, E., Marcus, D., Benzinger, T., Rich, K., Abraham, C., Milchenko, M., Robinson, C. Tags: NEURO-IMAGING (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Ni-39 * initial evaluation of an adenosine receptor agonist's ability to transiently disrupt the blood brain barrier (bbb) in patients with in normal brains
CONCLUSION: Significantly higher isotope counts were seen in each of these patients with presumably normal brains in the post-regadenoson setting. However, brain imaging with this standard cardiac imaging protocol, which includes different doses of isotope in the pre and post-regadenoson settings, does not allow a definitive statement regarding the ability of this agent to temporarily disrupt the BBB and allow entry of previously impermeable systemically administered compounds into the brain. Further studies are underway to answer this question definitively as transient disruption of the BBB would be of major importance to...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Jackson, S., Lodge, M., Piotrowski, A., Wahl, R., Grossman, S. Tags: NEURO-IMAGING (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Pt-06 * randomized trial of high-precision conformal radiation therapy compared to conventional radiotherapy in preservation of long-term neuro-cognitive outcomes in young patients with progressive or residual benign/low-grade brain tumors
CONCLUSIONS: We demonstrate high-precision conformal radiotherapy superior to conventional radiotherapy in preservation of neuropsychological functions in young patients with benign/low grade brain tumors. This is among few trials generating evidence for use of modern conformal RT from an appropriately-powered trial with clinically relevant endpoints and act as suitable benchmark for testing newer RT- technologies.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Jalali, R., Gupta, T., Goswami, S., Krishna, U., Dutta, D., Deodhar, J., Kannan, S., Sarin, R. Tags: PEDIATRIC CLINICAL TRIALS Source Type: research

Sp-03 * care of the caregiver: enhancing neuro-oncology patient care
UCSF Neuro Oncology has developed a formalized program to identify and meet the needs of caregivers of brain tumor patients. To date the program has targeted care to three groups of caregivers, those of new patients seen at clinic, caregivers of patients with newly diagnosed glioblastoma, and caregivers of patients deemed to be at " high risk", either by an interaction with the healthcare provider, or because of the phase in the illness trajectory. Caregiver assistance has been offered at specific points in the first 4 months of illness to 30 caregivers of patients with newly diagnosed glioblastoma, 13 of which received ca...
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Page, M., Molina, I., Patt, J., Chang, S. Tags: SUPPORTIVE AND PALLIATIVE CARE Source Type: research

IgG4-Related Disease: A Neuro-Ophthalmological Perspective
Abstract:Immunoglobulin G4–related disease (IgG4-RD) is a multifocal inflammatory disorder that causes tumefactive lesions with a dense lymphoplasmacytic infiltrate rich in IgG4 plasma cells and storiform-pattern fibrosis. The clinical symptoms are relatively mild, and the condition is usually recognized by organ swelling and damage. When referring to the ophthalmic manifestations of IgG4-RD, the term IgG4-related ophthalmic disease (IgG4-ROD) is used. IgG4-ROD is characterized by bilateral lacrimal gland enlargement accompanied by 3 distinctive features: infraorbital nerve enlargement, extraocular myositis, and compress...
Source: Journal of Neuro-Ophthalmology - December 1, 2014 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

EUNOS Neuro-Ophthalmology Update Course Held at Schloss Au, Switzerland, June 10–11, 2014
No abstract available
Source: Journal of Neuro-Ophthalmology - December 1, 2014 Category: Opthalmology Tags: Neuro-Ophthalmology News Source Type: research

Reviewer Lists for Neuro-Oncology
Source: Neuro-Oncology - December 23, 2014 Category: Cancer & Oncology Tags: Reviewer Lists for Neuro-Oncology Source Type: research

IgG4-Related Disease: A Neuro-Ophthalmological Perspective
Abstract: Immunoglobulin G4–related disease (IgG4-RD) is a multifocal inflammatory disorder that causes tumefactive lesions with a dense lymphoplasmacytic infiltrate rich in IgG4 plasma cells and storiform-pattern fibrosis. The clinical symptoms are relatively mild, and the condition is usually recognized by organ swelling and damage. When referring to the ophthalmic manifestations of IgG4-RD, the term IgG4-related ophthalmic disease (IgG4-ROD) is used. IgG4-ROD is characterized by bilateral lacrimal gland enlargement accompanied by 3 distinctive features: infraorbital nerve enlargement, extraocular myositis, and compres...
Source: Journal of Neuro-Ophthalmology - December 1, 2014 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Neuro-Behçet Disease Presenting With Oculopalatal Tremor
Abstract: A 39-year-old woman with a history of Behçet disease presented for evaluation of oscillopsia that began postpartum. Examination showed oculopalatal tremor (OPT), documented videographically. Brain magnetic resonance imaging revealed bilateral pseudohypertrophy of the inferior olivary nuclei. Treatment with gabapentin was initiated for OPT presumed secondary to neuro-Behçet disease.
Source: Journal of Neuro-Ophthalmology - February 26, 2015 Category: Opthalmology Tags: Clinical Observation Source Type: research

Neuro-Ophthalmology in Hungary
No abstract available
Source: Journal of Neuro-Ophthalmology - February 26, 2015 Category: Opthalmology Tags: Worldwide Neuro-Ophthalmology Source Type: research

Neuro-Ophthalmology in China
No abstract available
Source: Journal of Neuro-Ophthalmology - February 26, 2015 Category: Opthalmology Tags: Worldwide Neuro-Ophthalmology Source Type: research