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FDA, Google met to discuss use of search to find adverse drug reactions
Google met with the FDA last month to discuss the possibility of the FDA using Google search data to learn about drug side effects, according to a report in Bloomberg, which spotted a public record of the meeting and secured additional information from an FDA spokesperson. The talk appears to have been an informal, early-stage discussion on […]
Source: mobihealthnews - July 16, 2015 Category: Information Technology Authors: Jonah Comstock Tags: Government/Regulation adverse drug reaction adverse event FDA FDA adverse event reporting Google Google search side effects Source Type: news

Ben Miller on the search for alien life - podcast
Why are we so fascinated by the idea that we aren’t alone in the universe?Since abandoning his PhD in Physics at Cambridge for a career in comedy, Ben Miller has returned to his roots, publishing his first popular science book, It’s Not Rocket Science in 2012 and now The Aliens are Coming, published this month.In the book, Ben looks at animal intelligence; the latest search for alien intelligence; and the conditions needed to kickstart life. And he asks what evolution can tell us about extraterrestrial life. Continue reading...
Source: Guardian Unlimited Science - February 12, 2016 Category: Science Authors: Nicola Davis, Iain Chambers and Kit Buchan Tags: Science Alien life Seti (Search for Extraterrestrial Intelligence) Astronomy Space Source Type: news

Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain
SRGAP2 (Slit – Robo GTPase-activating protein 2) is a cytoplasmic protein found to be involved in neuronal branching, restriction of neuronal migration and restriction of the length and density of dendritic postsynaptic spines. The extended F-BAR (F-BARx) domain of SRGAP2 generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were collected from two significantly n...
Source: Acta Crystallographica Section D - November 28, 2016 Category: Biochemistry Authors: Sporny, M. Guez-Haddad, J. Waterman, D.G. Isupov, M.N. Opatowsky, Y. Tags: exhaustive search SRGAP2 F-BAR coiled coil molecular replacement research papers Source Type: research

Combinatorial refinement of thin-film microstructure, properties and process conditions: iterative nanoscale search for self-assembled TiAlN nanolamellae
Because of the tremendous variability of crystallite sizes and shapes in nanomaterials, it is challenging to assess the corresponding size – property relationships and to identify microstructures with particular physical properties or even optimized functions. This task is especially difficult for nanomaterials formed by self-organization, where the spontaneous evolution of microstructure and properties is coupled. In this work, two compositionally graded TiAlN films were (i) grown using chemical vapour deposition by applying a varying ratio of reacting gases and (ii) subsequently analysed using cross-sectional synchrotr...
Source: Journal of Applied Crystallography - November 30, 2016 Category: Physics Authors: Zalesak, J. Todt, J. Pitonak, R. K ö pf, A. Wei ß enbacher, R. Sartory, B. Burghammer, M. Daniel, R. Keckes, J. Tags: X-ray nanodiffraction thin films nanomaterials combinatorial search research papers Source Type: research

Authors' reply re: Surrogacy: a family-building option in search of legitimacy.
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 27, 2017 Category: OBGYN Authors: Authors' reply re: Surrogacy: a family-building option in search of legitimacy. Tags: BJOG Source Type: research

Everybody lies: how Google search reveals our darkest secrets
What can we learn about ourselves from the things we ask online? US data scientist Seth Stephens ‑Davidowitz analysed anonymous Google search results, uncovering disturbing truths about our desires, beliefs and prejudicesEverybody lies. People lie about how many drinks they had on the way home. They lie about how often they go to the gym, how much those new shoes cost, whether they read that book. They call in sick when they ’re not. They say they’ll be in touch when they won’t. They say it’s not about you when it is. They say they love you when they don’t. They say they’re happy while in the dumps. They say ...
Source: Guardian Unlimited Science - July 9, 2017 Category: Science Authors: Seth Stephens-Davidowitz Tags: Google Books Alphabet Technology Big data Search engines Internet Psychology Science Race issues World news Culture Source Type: news

Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland, Brandee L. Branche, Lauren E. Howard, Robert J. Hamilton, William J. Aronson, Martha K. Terris, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research

Authorship Order in Medical Education Publications: In Search of Practical Guidance for the Community.
This study describes principles commonly applied to authorship order decisions within the medical education community and educators' opinions about the significance of authorship order. Approach: A questionnaire was developed to ascertain current practices related to authorship decisions. Sixteen items were rated in terms of frequency of actual use and the desirability of the practice using a 4-point rating scale: 1 (never), 2 (sometimes), 3 (often), and 4 (always). Additional questions addressed the perceived significance of authorship order. The last set of questions provided information about respondents' personal and c...
Source: Teaching and Learning in Medicine - December 15, 2018 Category: Universities & Medical Training Authors: Authorship Order in Medical Education Publications: In Search of Practical Guidance for the Community. Tags: Teach Learn Med Source Type: research

Finding the best-fit background function for whole-powder-pattern fitting using LASSO combined with tree search
A new linear function for modelling the background in whole-powder-pattern fitting has been derived by applying LASSO (least absolute shrinkage and selection operator) and the technique of tree search. The background function (BGF) consists of terms bnL(2 θ /180) − n/2   and bnH(1   −   2 θ /180) − n/2 for the low- and high-angle sides, respectively. Some variable parameters of the BGF should be fixed at zero while others should be varied in order to find the best fit for a given data set without inducing overfitting. The LASSO algorithm can automatically select the variables in linear regression analysis. Ho...
Source: Journal of Applied Crystallography - February 14, 2021 Category: Physics Authors: Toraya, H. Tags: background functions LASSO tree search least absolute shrinkage and selection operator whole-powder-pattern fitting X-ray powder diffraction research papers Source Type: research

Neurosarcoidosis: a clinical approach to diagnosis and management
AbstractSarcoidosis is a rare but important cause of neurological morbidity, and neurological symptoms often herald the diagnosis. Our understanding of neurosarcoidosis has evolved from early descriptions of a uveoparotid fever to include presentations involving every part of the neural axis. The diagnosis should be suspected in patients with sarcoidosis who develop new neurological symptoms, those presenting with syndromes highly suggestive of neurosarcoidosis, or neuro-inflammatory disease where more common causes have been excluded. Investigation should look for evidence of neuro-inflammation, best achieved by contrast-...
Source: Journal of Neurology - May 1, 2017 Category: Neurology Source Type: research

Management of neurosarcoidosis: a clinical challenge
Purpose of review Sarcoidosis is a complex disease with many faces, and the clinical manifestation and course of neurosarcoidosis are particularly variable. Although neurosarcoidosis occurs in up to 10% of sarcoidosis patients, it can lead to significant morbidity and some mortality. Recent findings Three criteria are usually required for a diagnosis of (neuro)sarcoidosis: clinical and radiologic manifestations, noncaseating granulomas, and no evidence of alternative disease. Recent guidelines have helped to clarify criteria for diagnosing neurosarcoidosis. No firm guidelines exist on whether, when, and how treatment ...
Source: Current Opinion in Neurology - May 1, 2019 Category: Neurology Tags: WIDENING SPECTRUM OF CNS INFLAMMATORY DISORDERS OF THE CNS: Edited by Francesc Graus Source Type: research

Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid.
This study led to the identification of several proteins which can be used for the diagnosis and/or monitoring of neurosarcoidosis. These putative biomarkers have to be confirmed on a larger cohort and assessed for their sensitivity and specificity. PMID: 28751284 [PubMed - in process]
Source: Annales de Biologie Clinique - July 30, 2017 Category: Biochemistry Authors: Taibi L, Boursier C, Clodic G, Bolbach G, Bénéteau-Burnat B, Vaubourdolle M, Baudin B Tags: Ann Biol Clin (Paris) Source Type: research

An atypical case of neurosarcoidosis presenting with neovascular glaucoma
ConclusionsA patient with neurosarcoidosis presenting with compressive ischemic optic disc edema and neovascular glaucoma is described, increasing the diversity of clinical presentations and confirming the diagnostic challenge of neurosarcoidosis.
Source: Journal of Ophthalmic Inflammation and Infection - April 18, 2018 Category: Opthalmology Source Type: research

Magnetic resonance imaging and symptoms in patients with neurosarcoidosis and central diabetes insipidus.
CONCLUSION: Patients with both neurosarcoidosis and CDI symptoms often do not improve, despite the fact that brain MRI findings often improve following treatment. More studies involving detailed pathological analyses and longer follow-up periods are necessary. PMID: 31681969 [PubMed - in process]
Source: Endokrynologia Polska - November 6, 2019 Category: Endocrinology Authors: Kakehi E, Adachi S, Fukuyasu Y, Hashimoto Y, Sakurai S, Hirotani A, Danbara H, Shimizu K, Fujita R, Teraura H, Kotani K, Matsumura M Tags: Endokrynol Pol Source Type: research