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Isolated paediatric neurosarcoidosis presenting as epilepsia partialis continua: A case report and review of literature.
We report the clinical and radiological profile of a 7 year-old boy with epilepsia partialis continua (EPC) who was initially thought to have Acute Disseminated Encephalomyelitis (ADEM), but was subsequently found to have isolated neurosarcoidosis. Additionally, we performed a literature search on Medline and Embase and secondary sources of data such as reference list of articles reviewed. Whilst cranial neuropathy is the commonest presenting feature in adults with neurosarcoidosis, paediatric patients are more likely to present with seizures. Diagnosis presents a clinical challenge as a result of its protean manifestation...
Source: European Journal of Paediatric Neurology - May 16, 2013 Category: Neurology Authors: Anand G, Sin FE, Soilleux E, Chandra J, Piddington K, Quaghebeur G, Wilkinson N, Zaiwalla Z, Kennett R, McShane T Tags: Eur J Paediatr Neurol Source Type: research

Overnight Response to Infliximab in Neurosarcoidosis: A Case Report and Review of Infliximab Treatment Practice
ConclusionsInfliximab seems to be a fast-acting and effective drug for severe neurosarcoidosis. No systematic treatment strategy is available because of lack of controlled trials. Until then, therapy regimens may be adapted to those used in other medical fields where infliximab treatment is well established.
Source: Clinical Neuropharmacology - September 1, 2014 Category: Neurology Tags: Review Article Source Type: research

Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum
In this study, a 35-year-old Indian man with an undiagnosed progressive axial spondyloarthropathy (i.e., AS) is reported presenting with acute-onset longitudinally extensive transverse myelitis, a clinical subset of NMOSD. Neuromyelitis optica spectrum disorder (NMOSD), a primary demyelinating disorder of the central nervous system (CNS), is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels, which manifests with optic neuritis, longitudinally extensive transverse myelitis (LETM), area-postrema syndrome, brainstem syndrome diencephalic syndrome, and cerebral syndrome.1-4 Ankylosing spo...
Source: Herpes - July 22, 2022 Category: Infectious Diseases Authors: Ritwik Ghosh Md Devlina Roy Mois és León-Ruiz Shambaditya Das Souvik Dubey Juli án Benito-León Source Type: research

Analysis of soluble interleukin-2 receptor as CSF biomarker for neurosarcoidosis
Conclusions CSF sIL-2R parameters are elevated in patients with neurosarcoidosis, but this finding is not specific for neurosarcoidosis. Nevertheless, CSF sIL-2R parameters may help distinguishing neurosarcoidosis from MS and are associated with clinical, radiologic, and CSF disease activity markers of neurosarcoidosis. Classification of evidence This study provides Class II evidence that CSF sIL-2R parameters distinguish neurosarcoidosis from NINDs and MS.
Source: Neurology Neuroimmunology and Neuroinflammation - May 10, 2020 Category: Neurology Authors: Otto, C., Wengert, O., Unterwalder, N., Meisel, C., Ruprecht, K. Tags: Article Source Type: research

Neurosarcoidosis - a patient series
Tidsskr Nor Laegeforen. 2021 Mar 22;141(5). doi: 10.4045/tidsskr.20.0361. Print 2021 Mar 23.ABSTRACTBACKGROUND: Neurosarcoidosis is a rare form of sarcoidosis that affects the nervous system. The aim of the study was to survey clinical manifestations, findings from assessments and treatment strategies for patients with neurosarcoidosis.MATERIAL AND METHOD: The study performed a retrospective assessment of 17 patients with definitive, probable and possible neurosarcoidosis diagnosed in the period 2008-2019 at the Department of Neurology, Haukeland University Hospital.RESULTS: The average prevalence of definitive, probable o...
Source: Tidsskrift for den Norske Laegeforening - March 23, 2021 Category: General Medicine Authors: Emilia B ørhaug Christian Alexander Vedeler Source Type: research