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Neuro-Ophthalmology of Space Flight
Conclusions: We previously hypothesized that the optic nerve and ocular changes that we described in astronauts may be the result of orbital and cranial cephalad fluid shifts brought about by prolonged microgravity exposure. The findings we reported previously and continue to see in astronauts may represent parts of a spectrum of ocular and cerebral responses to extended microgravity exposure. Future investigations hopefully will lead to countermeasures that can be used to eliminate or lessen the magnitude of these potentially harmful findings before long-duration space flight including the possibility of a manned mission to Mars.
Source: Journal of Neuro-Ophthalmology - February 19, 2016 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research
Neuro-Behçet Disease Presenting With Oculopalatal Tremor
Abstract: A 39-year-old woman with a history of Behçet disease presented for evaluation of oscillopsia that began postpartum. Examination showed oculopalatal tremor (OPT), documented videographically. Brain magnetic resonance imaging revealed bilateral pseudohypertrophy of the inferior olivary nuclei. Treatment with gabapentin was initiated for OPT presumed secondary to neuro-Behçet disease.
Source: Journal of Neuro-Ophthalmology - February 26, 2015 Category: Opthalmology Tags: Clinical Observation Source Type: research
Neurosarcoidosis: a clinical approach to diagnosis and management
AbstractSarcoidosis is a rare but important cause of neurological morbidity, and neurological symptoms often herald the diagnosis. Our understanding of neurosarcoidosis has evolved from early descriptions of a uveoparotid fever to include presentations involving every part of the neural axis. The diagnosis should be suspected in patients with sarcoidosis who develop new neurological symptoms, those presenting with syndromes highly suggestive of neurosarcoidosis, or neuro-inflammatory disease where more common causes have been excluded. Investigation should look for evidence of neuro-inflammation, best achieved by contrast-...
Source: Journal of Neurology - May 1, 2017 Category: Neurology Source Type: research
Magnetic resonance imaging and symptoms in patients with neurosarcoidosis and central diabetes insipidus.
CONCLUSION: Patients with both neurosarcoidosis and CDI symptoms often do not improve, despite the fact that brain MRI findings often improve following treatment. More studies involving detailed pathological analyses and longer follow-up periods are necessary.
PMID: 31681969 [PubMed - in process]
Source: Endokrynologia Polska - November 6, 2019 Category: Endocrinology Authors: Kakehi E, Adachi S, Fukuyasu Y, Hashimoto Y, Sakurai S, Hirotani A, Danbara H, Shimizu K, Fujita R, Teraura H, Kotani K, Matsumura M Tags: Endokrynol Pol Source Type: research
Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum
In this study, a 35-year-old Indian man with an undiagnosed progressive axial spondyloarthropathy (i.e., AS) is reported presenting with acute-onset longitudinally extensive transverse myelitis, a clinical subset of NMOSD. Neuromyelitis optica spectrum disorder (NMOSD), a primary demyelinating disorder of the central nervous system (CNS), is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels, which manifests with optic neuritis, longitudinally extensive transverse myelitis (LETM), area-postrema syndrome, brainstem syndrome diencephalic syndrome, and cerebral syndrome.1-4 Ankylosing spo...
Source: Herpes - July 22, 2022 Category: Infectious Diseases Authors: Ritwik Ghosh Md Devlina Roy Mois és León-Ruiz Shambaditya Das Souvik Dubey Juli án Benito-León Source Type: research
Case Report: Uncommon Presentation of Neurosarcoidosis (P6.027)
CONCLUSIONS: Neurosarcoidosis is an atypical but treatable cause of subarachnoid hemorrhage. Complete work up is often challenging but essential in establishing a diagnosis that leads to optimal treatment.Study Supported by: Not applicable Disclosure: Dr. Lee has nothing to disclose. Dr. Khatri's institution has received research support from Penumbra, Inc. and Genentech, Inc. Dr. Kendler has nothing to disclose. Dr. Molano has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lee, I., Khatri, P., Kendler, A., Molano, J. Tags: General Neurology VI Source Type: research
Endoscopic biopsy for the diagnosis of neurosarcoidosis at the fourth ventricle outlet with hydrocephalus.
CONCLUSION: Endoscopic procedure is less invasive and more effective for biopsy of neurosarcoidosis with hydrocephalus, even if the lesion is located at the fourth ventricle outlet.
PMID: 26682088 [PubMed]
Source: Surgical Neurology International - December 20, 2015 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Isolated neurosarcoidosis presenting with multiple cranial nerve palsies.
CONCLUSIONS: Isolated neurosarcoidosis is difficult to diagnose. Successful diagnosis requires compatible clinical findings, histological demonstration of noncaseating granulomas, and exclusion of other granulomatous diseases. Isolated neurosarcoidosis has a relatively good clinical prognosis, which could be characteristic of the disease.
PMID: 27168947 [PubMed - as supplied by publisher]
Source: Surgical Neurology International - May 12, 2016 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Neurosarcoidosis: an update on diagnosis and therapy
Expert Rev Neurother. 2022 Aug 1. doi: 10.1080/14737175.2022.2108705. Online ahead of print.ABSTRACTINTRODUCTION: Clinically overt granulomatous involvement of the nervous system (i.e., neurosarcoidosis) can be seen in up to 10% of patients with sarcoidosis. Establishing a diagnosis of neurosarcoidosis is often challenging due to the heterogeneity of clinical presentations that are sometimes non-specific, and inaccessibility of tissue confirmation. Recommended treatments are based on expert opinions that are derived from clinical experience and limited data from retrospective studies, as data from randomized controlled stu...
Source: Expert Review of Neurotherapeutics - August 1, 2022 Category: Neurology Authors: Patompong Ungprasert Persen Sukpornchairak Brandon P Moss Manuel L Ribeiro Neto Daniel A Culver Source Type: research
