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Total 13238 results found since Jan 2013.

Peristalsis and propulsion of colonic content can occur after blockade of major neuro-neuronal and neuro-muscular transmitters in isolated guinea-pig colon.
In this study we investigated whether blockade of the major receptors that underlie excitatory neuro-muscular transmission are required for hexamethonium-resistant peristalsis to occur. Methods: Video imaging of colonic wall movements was used to make spatio-temporal maps and determine the velocity of peristalsis. Propagation of artificial fecal pellets in the guinea-pig distal colon was studied in hexamethonium, atropine, ω-conotoxin (GVIA), ibodutant (MEN15596) and tetrodotoxin (TTX). Results: Hexamethonium and ibodutant alone did not retard peristalsis. In contrast, ω-conotoxin abolished peristalsis in a proportion of...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 10, 2013 Category: Physiology Authors: Sia TC, Brookes SJ, Dinning PG, Wattchow DA, Spencer NJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Characteristics of Patients with Hereditary Transthyretin Amyloidosis-Polyneuropathy (ATTRv-PN) in NEURO-TTRansform, an Open-label Phase 3 Study of Eplontersen
ConclusionThe recruited population in the ongoing NEURO-TTRansform study has global representation characteristic of contemporary clinical practice.Trial RegistrationClinicalTrials.gov identifier NCT04136184.
Source: Neurology and Therapy - December 16, 2022 Category: Neurology Source Type: research

Late onset Wilson Disease with normal neuro-psychiatric status: A case report
CONCLUSIONS: In spite of being uncommon in later age, WD and its different variations like with normal neuro-psychiatric status should be considered as an etiology in cases of unexplained liver diseases.PMID:35638048 | PMC:PMC9142667 | DOI:10.1016/j.amsu.2022.103678
Source: Annals of Medicine - May 31, 2022 Category: Internal Medicine Authors: Bishal Dhakal K C Prabhat Abinash Karki Ayush Mohan Bhattarai Sachin Sapkota Binaya Subedi Abhinav Dahal Source Type: research

ITA-MNGIE: an Italian regional and national survey for mitochondrial neuro-gastro-intestinal encephalomyopathy
Abstract Mitochondrial neuro-gastro-intestinal encephalomyopathy (MNGIE) is a rare and unavoidably fatal disease due to mutations in thymidine phosphorylase (TP). Clinically it is characterized by gastrointestinal dysfunction, malnutrition/cachexia and neurological manifestations. MNGIE diagnosis remains a challenge mainly because of the complexity and rarity of the disease. Thus, our purposes were to promote a better knowledge of the disease in Emilia-Romagna region (ERR) by creating an accurate and dedicated network; to establish the minimal prevalence of MNGIE in Italy starting from ERR. Blood TP activity level...
Source: Neurological Sciences - March 22, 2016 Category: Neurology Source Type: research

Search for Genetic Modifiers of PSC: Time to Increase the Number of Needles in the Haystack.
Authors: Krawczyk M, Lammert F Abstract Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene locus has been shown to modulate the course of PSC. Here we briefly discuss the phenotypes related to this polymorphism and propose alternative directions of research t...
Source: Annals of Hepatology - October 24, 2017 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The search for noninvasive methods to identify liver fibrosis in children with nonalcoholic fatty liver disease.
Authors: Mandelia C, Kabbany MN, Conjeevaram Selvakumar PK, Alkhouri N Abstract Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity epidemic. Recent studies have clearly shown that the stage of fibrosis in adults with NAFLD is the most important histological feature in long-term outcomes and the development of liver-related complications. Despite the paucity of data regarding the natural history of pediatric NAFLD, its progression to cirrhosis and end-stage liver disease requiring liver transplantation is well documented. Given the high prevalence of NAFLD in children and adults, th...
Source: Future Medicine: Biomarkers in Medicine - March 10, 2018 Category: Internal Medicine Tags: Biomark Med Source Type: research

Search for Genetic Modifiers of PSC: Time to Increase the Number of Needles in the Haystack.
Authors: Krawczyk M, Lammert F Abstract Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene locus has been shown to modulate the course of PSC. Here we briefly discuss the phenotypes related to this polymorphism and propose alternative directions of research t...
Source: Annals of Hepatology - June 9, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Contribution of Turkey in Liver Transplant Research: A Scopus Database Search
CONCLUSIONS: Among countries, Turkey had the most living donor liver transplants in 2019 and could serve as a model to European countries for donor shortages. Although the United States performs 5 times more liver transplants than Turkey, their publications rate was almost 22 times more. Combining a workload of performing research and publishing along with transplant surgery is together hard to master. Although Turkey has valuable experiences and has opened frontiers in transplantation, publications need to keep up with their hard work and innovations.PMID:35607793 | DOI:10.6002/ect.2021.0491
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 24, 2022 Category: Transplant Surgery Authors: Oru ç Numan Gökçe Sevil Alkan Source Type: research

Aedes –Chikungunya Virus Interaction: Key Role of Vector Midguts Microbiota and Its Saliva in the Host Infection
Conclusion and Perspectives Arbovirus infections, such as CHIKV, have been growing worldwide and are becoming a major public health problem, especially in immuno-compromised classes such as children and the elderly. CHIKV is dangerous since it can cause arthritis, fever and other impairments, making it necessary to seek new ways to counter the proliferation of this virus. Knowing the vector’s competence is fundamentally important, including an understanding of the vector virus interaction and the modulation of this interaction. Despite advances in the knowledge of mosquito competence in the transmission of CHIKV, l...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Innate Lymphoid Cells in Helminth Infections —Obligatory or Accessory?
Conclusion ILC2s are clearly an inherent feature of the immune response to helminth infection, and in all probability their evolution has been driven by the threat of parasites. While in experimental model systems they are not always found to be essential, they are often center stage, particularly in the early phases of infection of each helminth system so far analyzed. They also form an important conceptual and mechanistic link with the allergic response that will allow us to understand in more detail the genesis and control of allergic disorders. In this respect, a much fuller analysis of ILC biology and function in the...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research