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Total 109056 results found since Jan 2013.

Repurposing Simvastatin in Parkinson's Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the < em > Substantia nigra < /em >
Int J Mol Sci. 2023 Jun 21;24(13):10414. doi: 10.3390/ijms241310414.ABSTRACTParkinson's disease is a neurodegenerative disorder characterized by oxidative stress and immune activation in the nigro-striatal pathway. Simvastatin regulates cholesterol metabolism and protects from atherosclerosis disease. Simvastatin-tween 80 was administered 7 days before sterotaxic intrastriatal administration of MPP+ (1-methyl-4-phenylpyridine) in rats. Fluorescent lipidic product formation, dopamine levels, and circling behavior were considered damage markers. Twenty-four hours and six days after, the animal group lesioned with MPP+ showed...
Source: Atherosclerosis - July 14, 2023 Category: Cardiology Authors: Mois és Rubio-Osornio Carmen T Gom éz-De León Sergio Montes Carmen Rubio Camilo R íos Antonio Monroy Jorge Morales-Montor Source Type: research

PROMIS ® and Neuro-QoLTM measures are valid measures of health-related quality of life among patients with familial chylomicronemia syndrome.
Conclusion: Results support the ability of PROMIS and Neuro-QoL measures to detect HRQOL impairment among patients with FCS. PROMIS and Neuro-QoL measures captured the functional impact and symptom burden associated with FCS, and the broad range of symptom severity experienced by patients with FCS. PMID: 32223345 [PubMed - as supplied by publisher]
Source: Expert Review of Cardiovascular Therapy - April 2, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Neuro-arrhythmology: a challenging field of action and research: a review from the Task Force of Neuro-arrhythmology of Italian Association of Arrhythmias and Cardiac Pacing
There is a growing interest in the study of the mechanisms of heart and brain interactions with the aim to improve the management of high-impact cardiac rhythm disorders, first of all atrial fibrillation. However, there are several topics to which the scientific interests of cardiologists and neurologists converge constituting the basis for enhancing the development of neuro-arrhythmology. This multidisciplinary field should cover a wide spectrum of diseases, even beyond the classical framework corresponding to stroke and atrial fibrillation and include the complex issues of seizures as well as loss of consciousness and sy...
Source: Journal of Cardiovascular Medicine - October 7, 2019 Category: Cardiology Tags: Review Source Type: research

Neuro-oncological Ventral Antigen 2 Regulates Splicing of Vascular Endothelial Growth Factor Receptor 1 and Is Required for Endothelial Function
In conclusion, NOVA2 was found to regulate FLT1 splicing in the endothelium. Loss of NOVA2 resulted in impaired endothelial function, at least partially dependent on VEGF. In PE patients, we observed a negative correlation between NOVA2 and sFLT1.PMID:35927413 | DOI:10.1007/s43032-022-01044-4
Source: Atherosclerosis - August 4, 2022 Category: Cardiology Authors: Veerle Kremer Jetta J Oppelaar Theresa Gimbel Susanne Koziarek Wessel Ganzevoort Mari ëlle G van Pampus Bert-Jan van den Born Liffert Vogt Christianne de Groot Reinier A Boon Source Type: research

Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux
Sci Rep. 2022 Oct 21;12(1):17665. doi: 10.1038/s41598-022-21617-2.ABSTRACTAutophagy is an intracellular recycling process that degrades harmful molecules and enables survival during starvation, with implications for diseases including dementia, cancer and atherosclerosis. Previous studies demonstrate how a limited number of transcription factors (TFs) can increase autophagy. However, this knowledge has not resulted in translation into therapy, thus, to gain understanding of more suitable targets, we utilized a systems biology approach. We induced autophagy by amino acid starvation and mTOR inhibition in HeLa, HEK 293 and S...
Source: Atherosclerosis - October 21, 2022 Category: Cardiology Authors: Aaron E Casey Wenjun Liu Leanne K Hein Timothy J Sargeant Stephen M Pederson Ville-Petteri M äkinen Source Type: research

Abstract 179: ACE2 Overexpression Prevents DOCA-Salt Hypertension by Modulating Cyclooxygenase Mediated Neuro-inflammation in the Central Nervous System Poster Session I
DOCA-salt hypertension, a low-renin hypertension model, is mediated through activation of the renin angiotensin system within the brain and is mediated by inflammation. We previously reported that central Angiotensin Converting Enzyme 2 (ACE2) overexpression prevents the development of hypertension induced by DOCA-salt in a transgenic mouse model (syn-hACE2; SA) with human ACE2 targeted selectively to neurons. The present study examined whether ACE2 modulates cyclooxygenase (COX)-mediated neuro-inflammation in DOCA-salt-mediated hypertension. DOCA-salt treatment (1 mg/g body weight DOCA, 1% saline in drinking water, 3 week...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Sriramula, S., Xia, H., Lazartigues, E. Tags: Poster Session I Source Type: research

Meta-Analysis Comparing Usefulness of Neuro-Humoral Antagonist Use among Patients ≥75 Years Versus < 75 Years Receiving Cardiac Resynchronization Therapy
Neuro-humoral antagonists are the foundation of heart failure therapy in patients with reduced left ventricular ejection fraction. Cardiac resynchronization therapy (CRT) has also been associated with improved outcomes in these patients. We aimed to evaluate the use of neuro-humoral antagonists in patients ≥75 years compared to
Source: The American Journal of Cardiology - February 3, 2018 Category: Cardiology Authors: Ahmed AlTurki, Riccardo Proietti, Hasan Alturki, Paul Dorian, Jeff S. Healey, Isabelle Greiss, Teresa Kus, Vidal Essebag, Thao Huynh Source Type: research

Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (From the Neuro-TAVI Trial)
This study sought to determine the frequency of neurologic injury, cerebral ischemic lesions, and cognitive dysfunction in subjects undergoing contemporary commercial transcatheter aortic valve implantation (TAVI) in the United States. Neuro-TAVR is the first prospective, multicenter study to employ serial systematic neurologic and cognitive assessments and DW-MRI (at 4 ±2 days postprocedure) to investigate the incidence and severity of neurologic injury following contemporary unprotected TAVI in the US.
Source: The American Journal of Cardiology - August 22, 2016 Category: Cardiology Authors: Alexandra J. Lansky, David Brown, Constantino Pena, Cody G. Pietras, Helen Parise, Vivian G. Ng, Stephanie Meller, Kevin J. Abrams, Michael Cleman, Pauliina Margolis, George Petrossian, Adam M. Brickman, Szilard Voros, Jeffrey Moses, John K. Forrest Source Type: research

Myocardial involvement in Beh çet's disease may be higher in patients with Neuro-Behçet's disease: a speckle tracking echocardiographic study
CONCLUSIONS: BD is associated with impaired LV and LA functions. LV-GLS and LA conduit strains of the patients with NBD were lower. NBD was an independent predictor of LV-GLS, suggesting a link between neurological manifestations and cardiac dysfunction in BD patients.PMID:34392811 | DOI:10.1080/00015385.2021.1965354
Source: Acta Cardiologica - August 16, 2021 Category: Cardiology Authors: Murat Sunbul Ipek Gursoy Midi Seda Kutlug Agackiran Esin Engin Selen Ucem Fatma Alibaz-Oner Nurten Sayar Haner Direskeneli Beste Ozben Sad ıc Source Type: research

Seasonal trends in hypertension in Poland: evidence from Google search engine query data.
CONCLUSIONS: In conclusion, hypertension is more likely to occur during winter months, which correlates with increased interest in searching phrase 'hypertension' in Google. PMID: 29297185 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - January 3, 2018 Category: Cardiology Authors: Płatek AE, Sierdziński J, Krzowski B, Szymański FM Tags: Kardiol Pol Source Type: research

Systematic Search for Present and Potential Portals of Entry for Infective Endocarditis
ConclusionsOur search for the POEs of present IEs was often successful, as was searching for an oral or dental or a gastrointestinal POE of a new IE episode. We advise the systematic performance of stomatologic examinations in patients with IE and performance of colonoscopy in patients ≥50 years of age or at high risk for colorectal cancer.
Source: Journal of the American College of Cardiology - January 12, 2016 Category: Cardiology Source Type: research

Google Search Activity and Heart Failure: Analysis of the US Population's Interest in Heart Failure and its Correlation with Heart Failure-Associated Mortality
While evidence-based management of heart failure (HF) has led to improved survival, it has also increased the overall symptom burden. Online health information is popular with many patients, who use search engines in their pursuit of information. Google Trends (GT) is a publicly available online tool for analyzing Google search data. GT has been used to examine the impact of infectious diseases and mental health, but not for cardiovascular disorders [1]. We hypothesized that internet search activity related to HF would mirror its prevalence in the United States and correlate positively with HF associated mortality.
Source: Journal of Cardiac Failure - November 11, 2020 Category: Cardiology Authors: Aakash Sheth, Ruchi Bhandari, Harsh Patel, Daniel P Morin, Paari Dominic Tags: Research Letter Source Type: research

The Dogged Search for Cryptic Effects of Ticagrelor: Wishful Thinking or Real Benefits Beyond P2Y12 Inhibition?
Abstract Greater protection against ischemic event occurrences has been associated with lower levels of platelet reactivity to adenosine diphosphate in patients with high risk coronary artery disease (1-3). The latter observations serve as the basis of the "platelet hypothesis"- i.e. greater inhibition of P2Y12 =less thrombotic event occurrence (4). Ticagrelor, a cyclo-pentyl-triazolo-pyrimidine, is indisputably a more potent P2Y12 inhibitor than clopidogrel (5) and when administered to patients with acute coronary syndrome (ACS) in the PLATelet inhibition and patient Outcomes (PLATO) trial resulted in a reduction...
Source: Circulation - October 26, 2016 Category: Cardiology Authors: Gurbel PA, Jeong YH, Tantry U Tags: Circulation Source Type: research