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Neuro-Ophthalmic Features of Autoimmune Encephalitides
Conclusions: The novel cell-surface protein-directed autoimmune encephalitis group can present with a wide range of afferent and efferent neuro-ophthalmic manifestations. Neuro-ophthalmologists should be familiar with these antibody-associated syndromes, which are treatable and often require a high index of suspicion for diagnosis.
Source: Journal of Neuro-Ophthalmology - August 25, 2020 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Re-defining response and treatment effects for neuro-oncology immunotherapy clinical trials
Abstract In much of medical oncology, including neuro-oncology, there is great interest to evaluate the therapeutic potential of immune-based therapies including vaccines, adoptive T cell strategies and modulators of immune checkpoint regulators such as cytotoxic T lymphocyte antigen 4 and programmed death 1. Immune-based treatments exert an indirect anti-tumor effect by generating potent, tumor-targeting immune responses. Robust anti-tumor immune responses have been shown to achieve encouraging radiographic responses across the spectrum of applied immunotherapeutics which are felt to be indicative of a bona fide ...
Source: Journal of Neuro-Oncology - February 24, 2015 Category: Cancer & Oncology Source Type: research

P21.04 Clinical pathway in glioma management; from NOSC (Neuro-Oncology Scientific Club) meetings to bedside practice
Characterizing a working-team concept in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum which has been operational in Iran since 2011 attempting towards a connect-approach in the management of CNS malignancies. NOSC comprises nation-wide group of experts and pursues its mission through interval strategic meetings, tumor-boards, case-discussions as well as publishing neuro-oncology updates and newsletters. The most recent NOSC clinical forum in Mashhad (February 2016), put together insights from internat...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Anvari, K., Fazl Ersi, M., Etemad-Rezaie, H., Nekooie, S., Arbabi, F., Ganjeifar, B., Bidouei, F., Nikkhah, K., Afarid, M., Torabi-Nami, M. Tags: P21 Miscellaneous Source Type: research

Immune checkpoint inhibitors: what neuro-ophthalmologists need to know
Purpose of review Immune checkpoint inhibitors are currently an exceedingly powerful tool in the management of hitherto incurable malignancies and their use in clinical practice is expected to increase in the near future. The purpose of this review is to discuss the current medical uses of checkpoint inhibitors with a focus on their neuro-ophthalmic side-effects. Recent findings Immune checkpoint inhibitors have emerged as a promising breakthrough in the treatment of several tumor types. However, these targeted therapies can induce a wide range of immune-related ophthalmic and neuro-ophthalmic toxicities. It is import...
Source: Current Opinion in Ophthalmology - October 4, 2019 Category: Opthalmology Tags: NEURO-OPHTHALMOLOGY: Edited by Dean M. Cestari Source Type: research

Insights from a Neuro-Rheumatology Clinic
Neuro-rheumatology is a fast-growing field. Better testing and imaging have increased recognition of once-infrequent diagnoses, such as neuro-sarcoidosis and amyloid beta-related angiitis. Concurrently, the rapid expansion of immunotherapy options to treat cancer and their untoward neurological side effects have increased the frequency of referrals to both neurologists and rheumatologists. Identifying and treating neurologic manifestations of... [Read More]
Source: The Rheumatologist - April 7, 2023 Category: Rheumatology Authors: Kristin Galetta, MD, Shamik Bhattacharyya, MD, & Simon M. Helfgott, MD Tags: Practice Management collaboration Collaboration Initiatives interdisciplinary neuro-rheumatology Neurology Source Type: research

Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy
A successful therapeutic paradigm established historically in oncology involves combining agents with potentially complementary mechanisms of antitumor activity into rationally designed regimens. For example, cocktails of cytotoxic agents, which were carefully designed based on mechanisms of action, dose, and scheduling considerations, have led to dramatic improvements in survival including cures for childhood leukemia, Hodgkin's lymphoma, and several other complex cancers. Outcome for glioblastoma, the most common primary malignant CNS cancer, has been more modest, but nonetheless our current standard of care derives from...
Source: Neuro-Oncology - October 29, 2015 Category: Cancer & Oncology Authors: Reardon, D. A., Gilbert, M. R., Wick, W., Liau, L. Tags: Articles Source Type: research

Ethical considerations of neuro-oncology trial design in the era of precision medicine
AbstractThe field of oncology is currently undergoing a paradigm shift. Advances in the understanding of tumor biology and in tumor sequencing technology have contributed to the shift towards precision medicine, the therapeutic framework of targeting the individual oncogenic changes each tumor harbors. The success of precision medicine therapies, such as targeted kinase inhibitors and immunotherapies, in other cancers have motivated studies in brain cancers. The high specificity and cost of these therapies also encourage a shift in clinical trial design away from randomized control trials towards smaller, more exclusive ea...
Source: Journal of Neuro-Oncology - May 29, 2017 Category: Cancer & Oncology Source Type: research

Neurosarcoidosis - a patient series
Tidsskr Nor Laegeforen. 2021 Mar 22;141(5). doi: 10.4045/tidsskr.20.0361. Print 2021 Mar 23.ABSTRACTBACKGROUND: Neurosarcoidosis is a rare form of sarcoidosis that affects the nervous system. The aim of the study was to survey clinical manifestations, findings from assessments and treatment strategies for patients with neurosarcoidosis.MATERIAL AND METHOD: The study performed a retrospective assessment of 17 patients with definitive, probable and possible neurosarcoidosis diagnosed in the period 2008-2019 at the Department of Neurology, Haukeland University Hospital.RESULTS: The average prevalence of definitive, probable o...
Source: Tidsskrift for den Norske Laegeforening - March 23, 2021 Category: General Medicine Authors: Emilia B ørhaug Christian Alexander Vedeler Source Type: research