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Impact of Covid-19 Pandemic on Neuro-Oncology Multidisciplinary Tumor Board in the Pre-Vaccine Era: the Normandy experience
CONCLUSION: The pre-vaccination era of the COVID19 pandemic did not impact the activity of neuro-oncology multidisciplinary tumor board in the Normandy region. The possible consequences in terms of public health (excess mortality) due to this tumor location should now be investigated.PMID:36870566 | PMC:PMC9979624 | DOI:10.1016/j.neuchi.2023.101429
Source: Neuro-Chirurgie - March 4, 2023 Category: Neurosurgery Authors: Marine Lacaud Arthur Leclerc Florent Marguet Maxime Faisant Paul Lesueur Houria El Ouazzani Fr édéric Di Fiore Chantal Hanzen Evelyne Emery Olivier Langlois Maxime Fontanilles Source Type: research
Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy
A successful therapeutic paradigm established historically in oncology involves combining agents with potentially complementary mechanisms of antitumor activity into rationally designed regimens. For example, cocktails of cytotoxic agents, which were carefully designed based on mechanisms of action, dose, and scheduling considerations, have led to dramatic improvements in survival including cures for childhood leukemia, Hodgkin's lymphoma, and several other complex cancers. Outcome for glioblastoma, the most common primary malignant CNS cancer, has been more modest, but nonetheless our current standard of care derives from...
Source: Neuro-Oncology - October 29, 2015 Category: Cancer & Oncology Authors: Reardon, D. A., Gilbert, M. R., Wick, W., Liau, L. Tags: Articles Source Type: research
Neuro-oncology biotech industry progress report
This article summarizes the current progress in brain tumor research as presented at 2015 The Brain Tumor Biotech Summit.
Source: Journal of Neuro-Oncology - February 20, 2016 Category: Cancer & Oncology Source Type: research
Impact of Covid-19 Pandemic on Neuro-Oncology Multidisciplinary Tumor Board in the Pre-Vaccine Era: the Normandy experience
CONCLUSION: The pre-vaccination era of the COVID19 pandemic did not impact the activity of neuro-oncology multidisciplinary tumor board in the Normandy region. The possible consequences in terms of public health (excess mortality) due to this tumor location should now be investigated.PMID:36870566 | DOI:10.1016/j.neuchi.2023.101429
Source: Neurochirurgie - March 4, 2023 Category: Neurosurgery Authors: Marine Lacaud Arthur Leclerc Florent Marguet Maxime Faisant Paul Lesueur Houria El Ouazzani Fr édéric Di Fiore Chantal Hanzen Evelyne Emery Olivier Langlois Maxime Fontanilles Source Type: research
A review of glioblastoma immunotherapy
ConclusionsCurrent clinical trials are exploring combination therapy and novel treatment strategies beyond immune checkpoint therapies and vaccine therapy such as CAR T cells. There is also an effort to establish synergy between immunotherapy and current standard of care. Furthermore, recent advances in personalized neoantigen vaccines suggest a shift towards personalized, patient-specific GBM treatment.
Source: Journal of Neuro-Oncology - April 5, 2020 Category: Cancer & Oncology Source Type: research
Translational considerations for immunotherapy clinical trials in pediatric neuro-oncology
Neoplasia. 2023 May 25;42:100909. doi: 10.1016/j.neo.2023.100909. Online ahead of print.ABSTRACTWhile immunotherapy for pediatric cancer has made great strides in recent decades, including the FDA approval of agents such as dinutuximab and tisgenlecleucel, these successes have rarely impacted children with pediatric central nervous system (CNS) tumors. As our understanding of the biological underpinnings of these tumors evolves, new immunotherapeutics are undergoing rapid clinical translation specifically designed for children with CNS tumors. Most recently, there have been notable clinical successes with oncolytic viruses...
Source: Neoplasia - May 27, 2023 Category: Cancer & Oncology Authors: Jessica B Foster Marta M Alonso Elias Sayour Tom B Davidson Mika L Persson Matthew D Dun Cassie Kline Sabine Mueller Nicholas A Vitanza Jasper van der Lugt Source Type: research
Atim-09. successful experience with clinical trials for high grade glioma in a community setting
CONCLUSIONS:Our experience demonstrates that clinical trials can successfully be carried out in a comprehensive community cancer center. Acquisition of complex neuro-oncology trials, high patient enrollment and retention, effective study management and reporting of quality data indicate our strong overall trial performance. Therefore, research centers in community hospitals can contribute their patient population to the success of multicenter clinical trials. Our patients are retained and enroll locally with minimal financial and travel burden, maintaining personalized care from their existing medical team.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Anker, L., Dobrea, L. Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research
Cytology versus HPV testing for cervical cancer screening in the general population: a DTA Review from the Cochrane Gynaecological, Neuro-oncology and Orphan Cancers Group, (CGNOC)
Cochrane Reviews are systematic reviews of research in health care and policy. They are internationally recognized as a high-quality source of evidence for decision-making. They collate and summarize all the best available research evidence on the effects of healthcare interventions or the accuracy of diagnostic tests into a systematic review.Diagnostic Test Accuracy Reviews (DTA) provide essential information regarding the accuracy of the available diagnostic tools for key decision makers, including patients, clinicians, guideline developers and researchers. The purpose of a Cochrane DTA review is very like the purpose ...
Source: Cochrane News and Events - August 14, 2017 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news
Vaccination strategies for neuro-oncology
Vaccination against cancer-associated antigens has long held the promise of inducting potent antitumor immunity, targeted cytotoxicity while sparing normal tissues, and long-lasting immunologic memory that can provide surveillance against tumor recurrence. Evaluation of vaccination strategies in preclinical brain tumor models has borne out the capacity for the immune system to effectively and safely eradicate established tumors within the central nervous system. Early phase clinical trials have established the feasibility, safety, and immunogenicity of several vaccine platforms, predominantly in patients with glioblastoma....
Source: Neuro-Oncology - October 29, 2015 Category: Cancer & Oncology Authors: Sampson, J. H., Mitchell, D. A. Tags: Articles Source Type: research
