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Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review
Conclusion: Since the implementation of the COVID-19 vaccination campaign in the past year, several post-COVID-vaccination neuro-ophthalmological complications have been described. However, considering the number of individuals that have been exposed to the vaccines, the risk seems very low, and the clinical outcome in most cases is favorable. Therefore, on a population level, the benefits of the vaccines far outweigh the risk of neuro-ophthalmological complications.
Source: Journal of Neuro-Ophthalmology - May 27, 2022 Category: Opthalmology Tags: Disease of the Year 2021 Encore: COVID-19 Source Type: research

Impact of Covid-19 Pandemic on Neuro-Oncology Multidisciplinary Tumor Board in the Pre-Vaccine Era: the Normandy experience
CONCLUSION: The pre-vaccination era of the COVID19 pandemic did not impact the activity of neuro-oncology multidisciplinary tumor board in the Normandy region. The possible consequences in terms of public health (excess mortality) due to this tumor location should now be investigated.PMID:36870566 | PMC:PMC9979624 | DOI:10.1016/j.neuchi.2023.101429
Source: Neuro-Chirurgie - March 4, 2023 Category: Neurosurgery Authors: Marine Lacaud Arthur Leclerc Florent Marguet Maxime Faisant Paul Lesueur Houria El Ouazzani Fr édéric Di Fiore Chantal Hanzen Evelyne Emery Olivier Langlois Maxime Fontanilles Source Type: research

Re-defining response and treatment effects for neuro-oncology immunotherapy clinical trials
Abstract In much of medical oncology, including neuro-oncology, there is great interest to evaluate the therapeutic potential of immune-based therapies including vaccines, adoptive T cell strategies and modulators of immune checkpoint regulators such as cytotoxic T lymphocyte antigen 4 and programmed death 1. Immune-based treatments exert an indirect anti-tumor effect by generating potent, tumor-targeting immune responses. Robust anti-tumor immune responses have been shown to achieve encouraging radiographic responses across the spectrum of applied immunotherapeutics which are felt to be indicative of a bona fide ...
Source: Journal of Neuro-Oncology - February 24, 2015 Category: Cancer & Oncology Source Type: research

Efferent neuro-ophthalmic complications of coronavirus disease 2019
We describe syndromes affecting ocular motility and elaborate on mechanisms of disease, including para-infectious inflammation, hypercoagulability, endothelial damage, and direct neurotropic viral invasion. Despite global vaccination programs, COVID-19 continues to pose an international threat that may rarely result in diplopia or nystagmus. Recent findings Efferent complications include cranial nerve palsies leading to diplopia, either isolated or in association with Miller Fisher syndrome. Nystagmus has been observed in the setting of hemorrhagic acute necrotizing encephalopathy and brainstem infarcts, and opsoclo...
Source: Current Opinion in Ophthalmology - October 14, 2022 Category: Opthalmology Tags: NEURO-OPHTHALMOLOGY: Edited by Dean Cestari Source Type: research

Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy
A successful therapeutic paradigm established historically in oncology involves combining agents with potentially complementary mechanisms of antitumor activity into rationally designed regimens. For example, cocktails of cytotoxic agents, which were carefully designed based on mechanisms of action, dose, and scheduling considerations, have led to dramatic improvements in survival including cures for childhood leukemia, Hodgkin's lymphoma, and several other complex cancers. Outcome for glioblastoma, the most common primary malignant CNS cancer, has been more modest, but nonetheless our current standard of care derives from...
Source: Neuro-Oncology - October 29, 2015 Category: Cancer & Oncology Authors: Reardon, D. A., Gilbert, M. R., Wick, W., Liau, L. Tags: Articles Source Type: research

Neuro-oncology biotech industry progress report
This article summarizes the current progress in brain tumor research as presented at 2015 The Brain Tumor Biotech Summit.
Source: Journal of Neuro-Oncology - February 20, 2016 Category: Cancer & Oncology Source Type: research

Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum
In this study, a 35-year-old Indian man with an undiagnosed progressive axial spondyloarthropathy (i.e., AS) is reported presenting with acute-onset longitudinally extensive transverse myelitis, a clinical subset of NMOSD. Neuromyelitis optica spectrum disorder (NMOSD), a primary demyelinating disorder of the central nervous system (CNS), is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels, which manifests with optic neuritis, longitudinally extensive transverse myelitis (LETM), area-postrema syndrome, brainstem syndrome diencephalic syndrome, and cerebral syndrome.1-4 Ankylosing spo...
Source: Herpes - July 22, 2022 Category: Infectious Diseases Authors: Ritwik Ghosh Md Devlina Roy Mois és León-Ruiz Shambaditya Das Souvik Dubey Juli án Benito-León Source Type: research

Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review
CONCLUSION: Since the implementation of the COVID-19 vaccination campaign in the past year, several post-COVID-vaccination neuro-ophthalmological complications have been described. However, considering the number of individuals that have been exposed to the vaccines, the risk seems very low, and the clinical outcome in most cases is favorable. Therefore, on a population level, the benefits of the vaccines far outweigh the risk of neuro-ophthalmological complications.PMID:35427282 | DOI:10.1097/WNO.0000000000001537
Source: Herpes - April 15, 2022 Category: Infectious Diseases Authors: Itay Lotan Melissa Lydston Michael Levy Source Type: research

Neuro-ophthalmic complications of varicella-zoster virus
Curr Opin Ophthalmol. 2023 Aug 22. doi: 10.1097/ICU.0000000000000996. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: This review broadly describes recent neuro-ophthalmic manifestations of varicella-zoster virus (VZV) reported in literature.RECENT FINDINGS: Despite varicella vaccination, the incidence of herpes zoster continues to rise, potentially leading to devastating consequences when ocular complications occur.A small but growing literature documents cases of retinal disease because of varicella reactivation after SARS-CoV-2 vaccination, ischemic optic neuropathy occurring during herpes zoster ophthalmicus, VZV-indu...
Source: Herpes - August 21, 2023 Category: Infectious Diseases Authors: Toluwalase O Tofade Bart K Chwalisz Source Type: research

Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication
Viruses. 2022 Apr 22;14(5):869. doi: 10.3390/v14050869.ABSTRACTWe previously isolated an HSV-1 mutant, KOS-NA, that contains two non-synonymous mutations in UL39. One of the mutations, resulting in an R950H amino acid substitution in ICP6, renders KOS-NA severely neuro-attenuated and significantly reduces HSV-1 latency. Vaccination of mice with KOS-NA prior to corneal challenge provides significant protection against HSV-1-mediated eye diseases even at a very low immunizing dose, indicating its utility as a vaccine scaffold. Because KOS-NA contains a neuro-attenuating mutation in a single gene, we sought to improve its saf...
Source: Herpes - May 28, 2022 Category: Infectious Diseases Authors: Hong Wang David J Davido Heba H Mostafa Lynda A Morrison Source Type: research

Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives
Viruses. 2022 Apr 20;14(5):848. doi: 10.3390/v14050848.ABSTRACTPrimary varicella-zoster virus (VZV) infection causes varicella, which remains a prominent public health concern in children. Current varicella vaccines adopt the live-attenuated Oka strain, vOka, which retains the ability to infect neurons, establish latency and reactivate, leading to vaccine-associated zoster in some vaccinees. Therefore, it is necessary to develop a safer next-generation varicella vaccine to help reduce vaccine hesitancy. This paper reviews the discovery and identification of the skin- and neuro-tropic factor, the open reading frame 7 (ORF7)...
Source: Herpes - May 28, 2022 Category: Infectious Diseases Authors: Wei Wang Dequan Pan Tong Cheng Hua Zhu Source Type: research