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Total 6899 results found since Jan 2013.

Opposing effects of alcohol on the immune system
Publication date: 4 February 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 65 Author(s): Tasha Barr, Christa Helms, Kathleen Grant, Ilhem Messaoudi Several studies have described a dose-dependent effect of alcohol on human health with light to moderate drinkers having a lower risk of all-cause mortality than abstainers, while heavy drinkers are at the highest risk. In the case of the immune system, moderate alcohol consumption is associated with reduced inflammation and improved responses to vaccination, while chronic heavy drinking is associated with a decreased frequency of lymp...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 4, 2015 Category: Psychiatry Source Type: research

Development of a skin- and neuro-attenuated live vaccine for varicella
Nat Commun. 2022 Feb 11;13(1):824. doi: 10.1038/s41467-022-28329-1.ABSTRACTVaricella caused by the primary infection of varicella-zoster virus (VZV) exerts a considerable disease burden globally. Current varicella vaccines consisting of the live-attenuated vOka strain of VZV are generally safe and effective. However, vOka retains full neurovirulence and can establish latency and reactivate to cause herpes zoster in vaccine recipients, raising safety concerns. Here, we rationally design a live-attenuated varicella vaccine candidate, v7D. This virus replicates like wild-type virus in MRC-5 fibroblasts and human PBMCs, the ca...
Source: Herpes - February 12, 2022 Category: Infectious Diseases Authors: Wei Wang Dequan Pan Wenkun Fu Xiangzhong Ye Jinle Han Lianwei Yang Jizong Jia Jian Liu Rui Zhu Yali Zhang Che Liu Jianghui Ye Anca Selariu Yuqiong Que Qinjian Zhao Ting Wu Yimin Li Jun Zhang Tong Cheng Hua Zhu Ningshao Xia Source Type: research

Vaccine donation supports search dogs
DOGS belonging to the Search and Rescue Dog Association (SARDA) England have received a free health check and vaccinations thanks to support from the veterinary corporate group CVS. The charity's dogs are all owned by their handlers and have recently completed a deployment helping in the parts of the UK that were hit by flooding over the winter, including Cumbria and Yorkshire. During their March national training weekend at the Castleshaw Outdoor Centre in Oldham, Vicky Weedon, a vet at the CVS practice West Mount Vets, gave all the dogs a health check and vaccinated them. Ms Weedon has a long-standing relationship with t...
Source: Veterinary Record - March 23, 2016 Category: Veterinary Research Tags: News and Reports Source Type: research

Transcriptomics of Haemophilus (Gl ässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens
Haemophilus (Gl ässerella) parasuis is the etiological agent of Glässer’s disease in pigs. Control of this disorder has been traditionally based on bacterins. The search for alternative vaccines has focused mainly...
Source: BMC Veterinary Research - November 6, 2018 Category: Veterinary Research Authors: Álvaro Álvarez-Estrada, César B. Gutiérrez-Martín, Elías F. Rodríguez-Ferri and Sonia Martínez-Martínez Tags: Research article Source Type: research

Ebolavirus: Comparison of Survivor Immunology and Animal Models in the Search for a Correlate of Protection
Ebola viruses are enveloped, single-stranded RNA viruses belonging to the Filoviridae family and can cause Ebola virus disease (EVD), a serious haemorrhagic illness with up to 90% mortality. The disease was first detected in Zaire (currently the Democratic Republic of Congo) in 1976. Since its discovery, Ebola virus has caused sporadic outbreaks in Africa and was responsible for the largest 2013–2016 EVD epidemic in West Africa, which resulted in more than 28,600 cases and over 11,300 deaths. This epidemic strengthened international scientific efforts to contain the virus and develop therapeutics and vaccines. Immunology...
Source: Frontiers in Immunology - February 19, 2021 Category: Allergy & Immunology Source Type: research

Plague vaccines: new developments in an ongoing search
Appl Microbiol Biotechnol. 2021 Jun 18. doi: 10.1007/s00253-021-11389-6. Online ahead of print.ABSTRACTAs the reality of pandemic threats challenges humanity, exemplified during the ongoing SARS-CoV-2 infections, the development of vaccines targeting these etiological agents of disease has become increasingly critical. Of paramount concern are novel and reemerging pathogens that could trigger such events, including the plague bacterium Yersinia pestis. Y. pestis is responsible for more human deaths than any other known pathogen and exists globally in endemic regions of the world, including the four corners region and North...
Source: Applied Microbiology and Biotechnology - June 18, 2021 Category: Microbiology Authors: Jason A Rosenzweig Emily K Hendrix Ashok K Chopra Source Type: research

SHEDDING LIGHT ON THE TOXICITY OF SARS-CoV-2-DERIVED PEPTIDE IN NON-TARGET COVID-19 ORGANISMS: A STUDY INVOLVING INBRED AND OUTBRED MICE
Neurotoxicology. 2022 Apr 5:S0161-813X(22)00048-1. doi: 10.1016/j.neuro.2022.03.012. Online ahead of print.ABSTRACTDespite advances in research on the vaccine and therapeutic strategies of COVID-19, little attention has been paid to the possible (eco)toxicological impacts of the dispersion of SARS-CoV-2 particles in natural environments. Thus, in this study, we aimed to evaluate the behavioral and biochemical consequences of the short exposure of outbred and inbred mice (male Swiss and C57Bl/6J mice, respectively) to PSPD-2002 (peptide fragments of the Spike protein of SARS-CoV-2) synthesized in the laboratory. Our data de...
Source: Neurotoxicology - April 8, 2022 Category: Neurology Authors: Thiarlen Marinho da Luz Amanda Pereira da Costa Ara újo Fernanda Neves Estr êla Rezende Abner Marcelino Silva Ives Charlie-Silva Helyson Lucas Bezerra Braz Paulo R S Sanches Md Mostafizur Rahman Dami à Barceló Guilherme Malafaia Source Type: research

Innate Lymphoid Cells in Helminth Infections —Obligatory or Accessory?
Conclusion ILC2s are clearly an inherent feature of the immune response to helminth infection, and in all probability their evolution has been driven by the threat of parasites. While in experimental model systems they are not always found to be essential, they are often center stage, particularly in the early phases of infection of each helminth system so far analyzed. They also form an important conceptual and mechanistic link with the allergic response that will allow us to understand in more detail the genesis and control of allergic disorders. In this respect, a much fuller analysis of ILC biology and function in the...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Viruses, Vol. 13, Pages 2522: The Valproic Acid Derivative Valpromide Inhibits Pseudorabies Virus Infection in Swine Epithelial and Mouse Neuroblastoma Cell Lines
Morales Pseudorabies virus (PRV) infection of swine can produce Aujeszky’s disease, which causes neurological, respiratory, and reproductive symptoms, leading to significant economic losses in the swine industry. Although humans are not the natural hosts of PRV, cases of human encephalitis and endophthalmitis caused by PRV infection have been reported between animals and workers. Currently, a lack of specific treatments and the emergence of new PRV strains against which existing vaccines do not protect makes the search for effective antiviral drugs essential. As an alternative to traditional nucleoside an...
Source: Viruses - December 15, 2021 Category: Virology Authors: Sabina Andreu In és Ripa Beatriz Praena Jos é Antonio López-Guerrero Raquel Bello-Morales Tags: Article Source Type: research

GSE142325 Comparison of multiple passages of VEEV V4020 to VEEV TC-83 at 2 days after intracranial inoculation in BALB/c mice
This study suggests a complex polygenic basis for neuro-virulent reversion in VEEV live attenuated vaccines and provides evidence for the advanced safety and genetic stability of V4020.
Source: GEO: Gene Expression Omnibus - June 1, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

The Effectiveness of Disaster Risk Communication: A Systematic Review of Intervention Studies
The objectives of the interventions were to improve the health knowledge and behaviour in relation to disasters, and to decrease the incidence of negative health events. The studies were chosen on that basis, and several studies reported additional outcomes that were outside the scope of this review. The knowledge, behaviour and incidence outcomes are described in detail in Appendix 3 (characteristics and results of included studies). Results of Individual Studies 1 Effect of Risk Communication Interventions to Promote Disaster Mitigation and Preparedness 1.1 Communication to Promote Mitigation and Preparedness for Infec...
Source: PLOS Currents Disasters - August 22, 2014 Category: Global & Universal Authors: dtbradley Source Type: research