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Vaccination: Whooping Cough (Pertussis) Vaccine

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Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age
ConclusionsThere was no overall association between delayed DTaP and food allergy, however children with delayed DTaP had less eczema and less use of eczema medication. Timing of routine infant immunizations may affect susceptibility to allergic disease.This article is protected by copyright. All rights reserved.
Source: Allergy - December 29, 2015 Category: Allergy & Immunology Authors: Nicholas Kiraly, Jennifer J Koplin, Nigel W Crawford, Samantha Bannister, Katie L Flanagan, Patrick G Holt, Lyle C Gurrin, Adrian J Lowe, Mimi LK Tang, Melissa Wake, Anne‐Louise Ponsonby, Shyamali C Dharmage, Katrina J Allen Tags: Original Article: Epidemiology and Genetics Source Type: research

Since The Start Of The Vaccines For Children Program, Uptake Has Increased, And Most Disparities Have Decreased Children's Vaccination In The United States
This study examined the impact that this intervention had on race and ethnicity–related and income-related disparities for diphtheria-tetanus-acellular pertussis, measles-mumps-rubella, and polio vaccinations, using data from the National Immunization Survey, 1995–2013. Vaccination rates increased across all races, ethnicities, and income groups following the introduction of the Vaccines for Children program. Disparities among race and ethnic groups narrowed considerably over time since the introduction of the vaccine program, although income-related disparities changed at different rates within racial and ethn...
Source: Health Affairs - February 8, 2016 Category: Global & Universal Authors: Walsh, B., Doherty, E., ONeill, C. Tags: Health Promotion/Disease Prevention, Maternal And Child Health, Vaccines Children ' s Vaccination In The United States Source Type: research

ADVERSE EVENTS POST-DTAP AND DTwP VACCINATION IN THAI CHILDREN.
In conclusion, children who received the DTwP vaccines were more likely to have early post-vaccination fever and higher fever but there was no significant difference between the two groups in parental days lost from work. PMID: 26867397 [PubMed - in process]
Source: Southeast Asian Journal of Tropical Medicine and Public Health - February 13, 2016 Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research

Immunogenicity and safety of quinvaxem® (diphtheria, tetanus, whole-cell pertussis, hepatitis b and haemophilus influenzae type b vaccine) given to vietnamese infants at 2 to 4 months of age.
IMMUNOGENICITY AND SAFETY OF QUINVAXEM® (DIPHTHERIA, TETANUS, WHOLE-CELL PERTUSSIS, HEPATITIS B AND HAEMOPHILUS INFLUENZAE TYPE B VACCINE) GIVEN TO VIETNAMESE INFANTS AT 2 TO 4 MONTHS OF AGE. Southeast Asian J Trop Med Public Health. 2015 Jul;46(4):753-63 Authors: Huu TN, Phuong NT, Toan NT, Thang HV Abstract Vietnam plans to replace the routine childhood diphtheria, pertussis and tetanus combination (DPT) vaccine with a pentavalent vaccine. The present study was performed to assess the immunogenicity and safety of the combined diphtheria, tetanus, whole-cell pertussis, hepatitis B (HepB), and Haemoph...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - February 13, 2016 Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research

Bordetella pertussis epidemiology and evolution in the light of pertussis resurgence.
Abstract Whooping cough, or pertussis, is resurgent in many countries world-wide. This is linked to switching from the use of whole cell vaccines to acellular vaccines in developed countries. Current evidence suggests that this has resulted in the earlier waning of vaccine-induced immunity, an increase in asymptomatic infection with concomitant increases in transmission and increased selection pressure for B. pertussis variants that are better able to evade vaccine-mediated immunity than older isolates. This review discusses recent findings in B. pertussis epidemiology and evolution in the light of pertussis resur...
Source: Infection, Genetics and Evolution - February 27, 2016 Category: Genetics & Stem Cells Authors: Sealey KL, Belcher T, Preston A Tags: Infect Genet Evol Source Type: research

A Novel IgM‐capture ELISA Using Recombinant Vag8 Fusion Protein for the Accurate and Early Diagnosis of Bordetella pertussis Infection
Abstract An enzyme‐linked immunosorbent assay (ELISA) that measures anti‐pertussis toxin (PT) IgG antibody has been used widely for the serodiagnosis of pertussis; however, the IgG‐based ELISA is inadequate for patients during the acute phase of the disease due to the slow response of anti‐PT IgG antibodies. To solve this problem, we developed a novel IgM‐capture ELISA that measures serum anti‐Bordetella pertussis Vag8 IgM levels for the accurate and early diagnosis of pertussis. First, we confirmed that Vag8 was highly expressed in all B. pertussis isolates tested (n = 30), but little or none in other Bord...
Source: Microbiology and Immunology - March 21, 2016 Category: Microbiology Authors: Nao Otsuka, Kensei Gotoh, Naoko Nishimura, Takao Ozaki, Yukitsugu Nakamura, Kiyohito Haga, Makoto Yamazaki, Fumio Gondaira, Kenji Okada, Yusuke Miyaji, Hiromi Toyoizumi‐Ajisaka, Keigo Shibayama, Yoshichika Arakawa, Kazunari Kamachi Tags: Original Article Source Type: research

Injection Site Lichenoid Dermatitis Following Pneumococcal Vaccination: Report and Review of Cutaneous Conditions Occurring at Vaccination Sites
Conclusions Dermatoses at the injection sites of vaccines can be granulomatous, immunity-related conditions, infections, lichenoid, neutrophilic, or pseudolymphomatous. Basal cell carcinoma and squamous cell carcinoma are the most common vaccination site-associated malignancies; however, melanoma and sarcomas (dermatofibrosarcoma protuberans, fibrosarcoma, and malignant fibrous histiocytoma) are also smallpox vaccine-related site neoplasms. A cutaneous immunocompromised district that is created by vaccine-induced local immunologic changes is hypothesized to be the pathogenesis of vaccination site reactions.
Source: Dermatology and Therapy - March 16, 2016 Category: Dermatology Source Type: research

Protective Effect of Contemporary Pertussis Vaccines: A Systematic Review and Meta-analysis
Conclusions. Although all contemporary aP and wP formulations protect against pertussis disease, in this meta-analysis the point estimate for short-term protective effect against WHO-defined pertussis in young children was lower for currently available aP vaccines than wP vaccines.
Source: Clinical Infectious Diseases - April 7, 2016 Category: Infectious Diseases Authors: Fulton, T. R., Phadke, V. K., Orenstein, W. A., Hinman, A. R., Johnson, W. D., Omer, S. B. Tags: ARTICLES AND COMMENTARIES Source Type: research

Quadracel: Vaccination Against Diphtheria, Tetanus, Pertussis, and Poliomyelitis in Children.
CONCLUSION: Quadracel should be recommended to parents who have children between the ages of 4 and 6 years who meet the necessary administration criteria and need to finalize their DTaP and IPV series. Quadracel's administration in the vaccination series replaces one additional injection, which may benefit children who are afraid of receiving shots and parents who need to schedule one less doctor's appointment. PMID: 27069343 [PubMed]
Source: P and T - April 15, 2016 Category: Drugs & Pharmacology Tags: P T Source Type: research

Resurgence of Vaccine-Preventable Diseases in the United States: Anesthetic and Critical Care Implications.
Abstract Vaccine-preventable diseases (VPDs) such as measles and pertussis are becoming more common in the United States. This disturbing trend is driven by several factors, including the antivaccination movement, waning efficacy of certain vaccines, pathogen adaptation, and travel of individuals to and from areas where disease is endemic. The anesthesia-related manifestations of many VPDs involve airway complications, cardiovascular and respiratory compromise, and unusual neurologic and neuromuscular symptoms. In this article, we will review the presentation and management of 9 VPDs most relevant to anesthesiolog...
Source: Anesthesia and Analgesia - April 14, 2016 Category: Anesthesiology Authors: Porteous GH, Hanson NA, Sueda LA, Hoaglan CD, Dahl AB, Ohlson BB, Schmidt BE, Wang CC, Fagley RE Tags: Anesth Analg Source Type: research

Bordetella pertussis: new concepts in pathogenesis and treatment
Purpose of review: The purpose of this review is to summarize and discuss recent findings and selected topics of interest in Bordetella pertussis virulence and pathogenesis and treatment of pertussis. It is not intended to cover issues on immune responses to B. pertussis infection or problems with currently used pertussis vaccines. Recent findings: Studies on the activities of various B. pertussis virulence factors include the immunomodulatory activities of filamentous hemagglutinin, fimbriae, and adenylate cyclase toxin. Recently emerging B. pertussis strains show evidence of genetic selection for vaccine escape mutants,...
Source: Current Opinion in Infectious Diseases - April 29, 2016 Category: Infectious Diseases Tags: PATHOGENESIS AND IMMUNE RESPONSE: Edited by Dennis L. Stevens Source Type: research

Antibody Persistence in Young Children 5 Years after Vaccination with Combined Haemophilus influenzae type b-Neisseria meningitidis Serogroup C or MenC Conjugate Vaccines Co-Administered with DTPa-Containing and Pneumococcal Conjugate Vaccines.
CONCLUSION: Approximately 5 years after booster vaccination, the majority of children retained seroprotective anti-PRP antibody concentrations. The percentage of children retaining seroprotective rSBA-MenC titres was low (≤40%), suggesting that a significant proportion of children may be unprotected against MenC disease. PMID: 27145999 [PubMed - as supplied by publisher]
Source: Clinical and Vaccine Immunology - May 3, 2016 Category: Allergy & Immunology Authors: Tejedor JC, Brzostek J, Konior R, Grunert D, Kolhe D, Baine Y, Van Der Wielen M Tags: Clin Vaccine Immunol Source Type: research

A Novel IgM‐capture enzyme‐linked immunosorbent assay using recombinant Vag8 fusion protein for the accurate and early diagnosis of Bordetella pertussis infection
ABSTRACT An ELISA that measures anti‐PT IgG antibody has been used widely for the serodiagnosis of pertussis; however, the IgG‐based ELISA is inadequate for patients during the acute phase of the disease because of the slow response of anti‐PT IgG antibodies. To solve this problem, we developed a novel IgM‐capture ELISA that measures serum anti‐Bordetella pertussis Vag8 IgM levels for the accurate and early diagnosis of pertussis. First, we confirmed that Vag8 was highly expressed in all B. pertussis isolates tested (n = 30), but little or none in other Bordetella species, and that DTaP vaccines did not induc...
Source: Microbiology and Immunology - May 17, 2016 Category: Microbiology Authors: Nao Otsuka, Kensei Gotoh, Naoko Nishimura, Takao Ozaki, Yukitsugu Nakamura, Kiyohito Haga, Makoto Yamazaki, Fumio Gondaira, Kenji Okada, Yusuke Miyaji, Hiromi Toyoizumi‐Ajisaka, Keigo Shibayama, Yoshichika Arakawa, Kazunari Kamachi Tags: Original Article Source Type: research

Adult vaccination against tetanus and diphtheria: The European perspective
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - May 31, 2016 Category: Allergy & Immunology Authors: Birgit Weinberger Tags: Review Source Type: research

How I vaccinate blood and marrow transplant recipients
Vaccination guidelines for recipients of blood and marrow transplantation (BMT) have been published by 3 major societies: American Blood and Marrow Transplantation, European Group of Blood and Marrow Transplantation, and Infectious Disease Society of America. Despite these extensive review articles, clinicians caring for BMT recipients continue to field frequently asked questions (FAQs) regarding the "who, when, and how" of feasible and effective posttransplant vaccination, frequently in the absence of adequate data. This may reflect discomfort with a "one size fits all" policy that makes no adjustments for different postt...
Source: Blood - June 8, 2016 Category: Hematology Authors: Carpenter, P. A., Englund, J. A. Tags: Pediatric Hematology, Transplantation, How I Treat, Free Research Articles, Clinical Trials and Observations Source Type: research