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Total 86952 results found since Jan 2013.

Concepts require flexible grounding
Brain Lang. 2023 Sep 13;245:105322. doi: 10.1016/j.bandl.2023.105322. Online ahead of print.ABSTRACTResearch on semantic memory has a problem. On the one hand, a robust body of evidence implicates sensorimotor regions in conceptual processing. On the other hand, a different body of evidence implicates a modality independent semantic system. The standard solution to this tension is to posit a hub-and-spoke system with modality independent hubs and modality specific spokes. In this paper, I argue in support of an alternative view of grounding which remains committed to neural reenactment but emphasizes the multimodal and mul...
Source: Brain and Language - September 15, 2023 Category: Neurology Authors: Guy Dove Source Type: research

40Hz electroacupuncture relieves the memory dysfunction of 5xFAD mice by regulating neuronal electrical activity
Brain Res. 2023 Sep 13:148576. doi: 10.1016/j.brainres.2023.148576. Online ahead of print.ABSTRACTIn this investigation, we probed the impacts of 40Hz Electroacupuncture (EA) on the cognitive function and brain activity in 5xFAD mice. Three groups of mice were constituted: the Model group of 5xFAD mice, the Wild Type (WT) group of littermate controls, and the EA group of 5xFAD mice subjected to EA treatment. Behavioral tests were conducted to evaluate memory function and anxiety levels, while the presence of Aβ plaques were detected via immunostaining, and neuronal activity was measured using multichannel recordings. Our ...
Source: Brain Research - September 15, 2023 Category: Neurology Authors: Jifei Miao Xiaoming Liu Jiao Lan Source Type: research

Activation of adenosine A < sub > 1 < /sub > receptor potentiates metabotropic glutamate receptor 1-mediated Ca < sup > 2+ < /sup > mobilization in the rat hippocampal marginal zone
In this study, potentiation of the mGluR1-mediated response by A1R activation was demonstrated in hippocampal CR cells. Fluorescence imaging revealed that the application of A1R agonists intensified mGluR1-induced elevation of intracellular Ca2+ concentration ([Ca2+]i). Activation of A1R did not change [Ca2+]i. The potentiated responses were independent of extracellular Ca2+ and prevented by the Gi inhibitor. The potentiation of mGluR1-induced [Ca2+]i. elevation was also enhanced by mGluR2/3 activation. These results suggest that mGluR1 and A1R cooperatively influence postnatal hippocampal development by facilitating Ca2+ ...
Source: Brain Research - September 15, 2023 Category: Neurology Authors: Megumi Taketo Source Type: research

Cognitive-exercise dual-task intervention ameliorates cognitive decline in natural aging rats via inhibiting the promotion of LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3 β Pathway
This study aimed to investigate the effects of CEDI and the role of regulation of the lncRNA NEAT1/miR-124-3p on the caveolin-1-PI3K/Akt/GSK3β pathway in CEDI improving cognitive function. Forty 18-month-old natural aging rats were randomly assigned to four groups: exercise training group, cognitive training group, CEDI group, and aging control group, and underwent 12 weeks of intervention. A novel object recognition test was performed to determine the cognitive function, and the hippocampus was separated three days after the behavioral tests for further molecular detection. In an in vitro study, the mouse hippocampal neu...
Source: Brain Research - September 15, 2023 Category: Neurology Authors: Tiancong Li Xue Tao Ruifeng Sun Conglin Han Xiaoling Li Ziman Zhu Wenshan Li Peiling Huang Weijun Gong Source Type: research

Neurological presentation of profound hypothyroidism
Pract Neurol. 2023 Sep 15:pn-2023-003859. doi: 10.1136/pn-2023-003859. Online ahead of print.NO ABSTRACTPMID:37714702 | DOI:10.1136/pn-2023-003859
Source: Practical Neurology - September 15, 2023 Category: Neurology Authors: Christopher Paisey Gurjit Chohan Source Type: research

MicroRNA-125a-3p modulate amyloid β-protein through the MAPK pathway in Alzheimer's disease
CONCLUSION: Our study indicates that targeting miR-125a-3p may be an applicable therapy for AD in the future. However, more in vitro and in vivo studies with more samples are needed to confirm these results.PMID:37711111 | DOI:10.2174/1567205020666230913105811
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Xi-Chen Zhu Meng-Zhuo Zhu Jing Lu Qing-Yu Yao Jia-Wei Hu Wen-Jun Long Sha-Sha Ruan Wen-Zhuo Dai Rong Li Source Type: research

Early Detection of Dementia using Risk Classification in MCI: Outcomes of Shanghai Mild Cognitive Impairment Cohort Study
CONCLUSION: A simple risk classification using the rt. HV and neuropsychological test scores, including those from the ADAS-Cog-C and PACC, could be a practicable and efficient approach to identifying individuals at risk of all-cause dementia.PMID:37711110 | DOI:10.2174/1567205020666230914161034
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Bin Zhou Qianhua Zhao Shinsuke Kojima Ding Ding Satoshi Higashide Masanori Fukushima Zhen Hong Source Type: research

Concepts require flexible grounding
Brain Lang. 2023 Sep 13;245:105322. doi: 10.1016/j.bandl.2023.105322. Online ahead of print.ABSTRACTResearch on semantic memory has a problem. On the one hand, a robust body of evidence implicates sensorimotor regions in conceptual processing. On the other hand, a different body of evidence implicates a modality independent semantic system. The standard solution to this tension is to posit a hub-and-spoke system with modality independent hubs and modality specific spokes. In this paper, I argue in support of an alternative view of grounding which remains committed to neural reenactment but emphasizes the multimodal and mul...
Source: Brain and Language - September 15, 2023 Category: Neurology Authors: Guy Dove Source Type: research

Neurological presentation of profound hypothyroidism
Pract Neurol. 2023 Sep 15:pn-2023-003859. doi: 10.1136/pn-2023-003859. Online ahead of print.NO ABSTRACTPMID:37714702 | DOI:10.1136/pn-2023-003859
Source: Practical Neurology - September 15, 2023 Category: Neurology Authors: Christopher Paisey Gurjit Chohan Source Type: research

Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway
CONCLUSION: Rhein attenuates cerebral I/R injury by inhibiting ferroptosis via the NRF2/SLC7A11/GPX4 axis, highlighting its potential as a therapeutic agent for ischemic stroke.PMID:37714424 | DOI:10.1016/j.expneurol.2023.114541
Source: Experimental Neurology - September 15, 2023 Category: Neurology Authors: Hua Liu Tian-Ai Zhang Wen-Yue Zhang Si-Rui Huang Yue Hu Jia Sun Source Type: research

Concepts require flexible grounding
Brain Lang. 2023 Sep 13;245:105322. doi: 10.1016/j.bandl.2023.105322. Online ahead of print.ABSTRACTResearch on semantic memory has a problem. On the one hand, a robust body of evidence implicates sensorimotor regions in conceptual processing. On the other hand, a different body of evidence implicates a modality independent semantic system. The standard solution to this tension is to posit a hub-and-spoke system with modality independent hubs and modality specific spokes. In this paper, I argue in support of an alternative view of grounding which remains committed to neural reenactment but emphasizes the multimodal and mul...
Source: Brain and Language - September 15, 2023 Category: Neurology Authors: Guy Dove Source Type: research

MicroRNA-125a-3p modulate amyloid β-protein through the MAPK pathway in Alzheimer's disease
CONCLUSION: Our study indicates that targeting miR-125a-3p may be an applicable therapy for AD in the future. However, more in vitro and in vivo studies with more samples are needed to confirm these results.PMID:37711111 | DOI:10.2174/1567205020666230913105811
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Xi-Chen Zhu Meng-Zhuo Zhu Jing Lu Qing-Yu Yao Jia-Wei Hu Wen-Jun Long Sha-Sha Ruan Wen-Zhuo Dai Rong Li Source Type: research

Early Detection of Dementia using Risk Classification in MCI: Outcomes of Shanghai Mild Cognitive Impairment Cohort Study
CONCLUSION: A simple risk classification using the rt. HV and neuropsychological test scores, including those from the ADAS-Cog-C and PACC, could be a practicable and efficient approach to identifying individuals at risk of all-cause dementia.PMID:37711110 | DOI:10.2174/1567205020666230914161034
Source: Current Alzheimer Research - September 15, 2023 Category: Neurology Authors: Bin Zhou Qianhua Zhao Shinsuke Kojima Ding Ding Satoshi Higashide Masanori Fukushima Zhen Hong Source Type: research

Retinal microvasculature features in patients with migraine: a systematic review and meta-analysis
ConclusionMigraine patients are prone to retinal microcirculation disorders, such as decreased blood vessel density and increased avascular area in the fovea. This provides a theoretical basis for OCTA as a candidate for rapid, non-invasive diagnosis of migraine.
Source: Frontiers in Neurology - September 15, 2023 Category: Neurology Source Type: research

Success of conservative therapy for chronic subdural hematoma patients: a systematic review
ConclusionConservative therapy is reported to be successful in the majority of cSDH patients who have either no, or only mild symptoms. Hematoma volume, low hematoma density and absence of paresis could be factors associated with success. However, further research is warranted in order to establish factors consistently associated with a successful conservative therapy.OtherNo funding was acquired for this study. The study was not registered nor was a study protocol prepared.
Source: Frontiers in Neurology - September 15, 2023 Category: Neurology Source Type: research