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Total 39823 results found since Jan 2013.
Myelin oligodendrocyte glycoprotein antibody and N-methyl-d-aspartate receptor antibody overlapping syndrome: insights from the recent case reports
Clin Exp Immunol. 2023 Sep 19:uxad109. doi: 10.1093/cei/uxad109. Online ahead of print.ABSTRACTThe overlapping of two or more types of neural autoantibodies in one patient has increasingly been documented in recent years. The coexistence of myelin oligodendrocyte glycoprotein (MOG) and N-methyl-d-aspartate receptor (NMDAR) antibodies is most common, which leads to a unique condition known as the MOG antibody and NMDAR antibody overlapping syndrome (MNOS). Here, we have reviewed the pathogenesis, clinical manifestations, paraclinical features, and treatment of MNOS. Forty-nine patients with MNOS were included in this study....
Source: Clinical and Developmental Immunology - September 19, 2023 Category: Allergy & Immunology Authors: Bing-Qing Du Qi-Lun Lai Er-Chuang Li Meng-Ting Cai Gao-Li Fang Chun-Hong Shen Yin-Xi Zhang Mei-Ping Ding Source Type: research
A Ruptured Cystic Echinococcosis in the Gallbladder and Intra/Extrahepatic Biliary Tract, Radiological and Surgical Imaging Findings
Turkiye Parazitol Derg. 2023 Sep 18;47(3):200-203. doi: 10.4274/tpd.galenos.2023.65265.ABSTRACTCystic echinococcosis is a common parasitic infestation that can still cause serious complications in endemic areas. Intrabiliary rupture is a well-defined complication, but rupture into the gallbladder is rare. The disease may present with cholecystitis and cholangitis. Clinicians and radiologists working in the emergency room will find the management of the disease much easier if they become familiar with the clinical and radiological findings of the cyst. In this article, a 28-year-old male admitted to the emergency department...
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Saim T ürkoğlu Abdurrahman Ekici Leyla Turgut Çoban İlyas Dündar Ozan Okyay Esra G ürbüz Source Type: research
Sub-second whole brain T < sub > 2 < /sub > mapping via multiband SENSE multiple overlapping-echo detachment imaging and deep learning
Phys Med Biol. 2023 Sep 19. doi: 10.1088/1361-6560/acfb71. Online ahead of print.ABSTRACTObjective.Most quantitative magnetic resonance imaging (qMRI) methods are time-consuming. Multiple overlapping-echo detachment (MOLED) imaging can achieve quantitative parametric mapping of a single slice within around one hundred milliseconds. Nevertheless, imaging the whole brain, which involves multiple slices, still takes a few seconds. To further accelerate qMRI, we introduce multiband SENSE (MB-SENSE) technology to MOLED to realize simultaneous multi-slice T2mapping.
Approach.The multiband MOLED (MB-MOLED) pulse sequence ...
Source: Physics in Medicine and Biology - September 19, 2023 Category: Physics Authors: Simin Li Taishan Kang Jian Wu Weikun Chen Qing Lin Zhigang Wu Jiazheng Wang Congbo Cai Shuhui Cai Source Type: research
Smell and Taste Disorders in Primary Care
Am Fam Physician. 2023 Sep;108(3):240-248.ABSTRACTDisorders of smell and taste are reported by approximately one-fifth of people 40 years and older, and one-third of people 80 years and older. These disorders affect quality of life and the ability to identify smoke and toxins. Smell and taste disorders can be early signs of dementia or Parkinson disease and are associated with increased mortality. Dysfunction may be apparent or may develop insidiously. Screening questionnaires are available, but many patients are unaware of their disorder. Most smell and taste disorders are due to sinonasal disease but also could be caused...
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Dillon J Savard Francesca G Ursua Heidi L Gaddey Source Type: research
mpMRI-targeted biopsy of the prostate in men ≥ 75 years. 7-year report from a high-volume referral center
CONCLUSION: After evaluation of a large patient cohort, we show that age≥75 years represents a significant risk factor for the detection of clinically significant prostate cancer. Further studies on mid- and long term outcome are necessary to draw conclusions for clinical decision making in this patient cohort.PMID:37718788 | DOI:10.3233/CH-238101
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Michael Chaloupka Nikolaos Pyrgidis Benedikt Ebner Paulo Pfitzinger Yannic Volz Elena Berg Benazir Abrarova Michael Atzler Troya Ivanova Paulo Pfitzinger Christian G Stief Maria Apfelbeck Dirk-Andr é Clevert Source Type: research
Baseline prostate health index risk category and risk category changes during active surveillance predict grade reclassification
CONCLUSIONS: Baseline PHI risk category and PHI changes over time were both independent predictors of GR after confirmatory biopsy, but the added benefit over PSAD seemed modest. However, baseline PHI and PHI risk category changes provided clinically useful risk stratification for time to GR, so further evaluation of PHI's ability to help reduce the frequency of mpMRI and/or surveillance biopsies with more PHI data points over time may be warranted.PMID:37722985 | DOI:10.1016/j.urolonc.2023.08.011
Source: Urologic Oncology - September 18, 2023 Category: Urology & Nephrology Authors: Claire M de la Calle Yuezhou Jing Mufaddal M Mamawala Patricia Landis Katarzyna J Macura Bruce J Trock Jonathan I Epstein Lori J Sokoll Christian P Pavlovich Source Type: research
The Value of < sup > 18 < /sup > F-FDG PET/MRI in Detecting Lumbar Radiculopathy for Selective Percutaneous Endoscopic Discectomy: a Case Report
Nucl Med Mol Imaging. 2023 Oct;57(5):247-250. doi: 10.1007/s13139-023-00797-3. Epub 2023 Mar 29.ABSTRACTMagnetic resonance imaging (MRI) is the most popular imaging modality for investigating intervertebral disc herniation. However, it has a high chance for identifying incidental findings that are morphologically or structurally abnormal but not responsible for patients' symptoms. Although a previous study suggested that 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) may help identify neuroinflammation in lumbar radiculopathy, there is currently no direct evidence obtaine...
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Chih-Ying Su Guo-Shu Huang Wei-Chou Chang Chih-Chien Wang Chun-Wen Chen Yi-Chih Hsu Source Type: research
Stimuli-Responsive Codelivery System Self-Assembled from < em > in Situ < /em > Dynamic Covalent Reaction of Macrocyclic Disulfides for Cancer Magnetic Resonance Imaging and Chemotherapy
ACS Appl Mater Interfaces. 2023 Sep 18. doi: 10.1021/acsami.3c10245. Online ahead of print.ABSTRACTSupramolecular self-assembly has gained increasing attention to construct multicomponent drug delivery systems for cancer diagnosis and therapy. Despite that these self-assembled nanosystems present surprising properties beyond that of each subcomponent, the spontaneous nature of co-self-assembly causes significant difficulties in control of the synthesis process and consequently leads to unsatisfactory influences in downstream applications. Hence, we utlized an in situ dynamic covalent reaction based on thiol-disulfide excha...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Xiaoxia Wu Dinghu Zhang Ting Pan Jianwei Li Yujiao Xie Chenguang Zhang Chunshu Pan Zhewei Zhang Jie Lin Aiguo Wu Guoliang Shao Source Type: research
Infant body composition: A comprehensive overview of assessment techniques, nutrition factors, and health outcomes
Nutr Clin Pract. 2023 Oct;38 Suppl 2:S7-S27. doi: 10.1002/ncp.11059.ABSTRACTBody composition assessment is a valuable tool for clinical assessment and research that has implications for long-term health. Unlike traditional measurements such as anthropometrics or body mass index, body composition assessments provide more accurate measures of body fatness and lean mass. Moreover, depending on the technique, they can offer insight into regional body composition, bone mineral density, and brown adipose tissue. Various methods of body composition assessment exist, including air displacement plethysmography, dual-energy x-ray ab...
Source: Nutrition in Clinical Practice - September 18, 2023 Category: Nutrition Authors: Maggie L Jerome Vivian Valcarce Laura Lach Elena Itriago Ariel A Salas Source Type: research
Relationship between seminal vesicle displacement and distribution of hydrogel spacer within the perirectal space in prostate radiotherapy
In conclusion, SV cranial displacement was influenced by HS lateral distribution of ≥1.00 cm in the upper two slices. Therefore, when the sigmoid colon or small bowel is depressed in rectovesical excavation and SV needs to be included in the target volume, HS insertion should be performed carefully.PMID:37719041 | PMC:PMC10502802 | DOI:10.3892/mco.2023.2674
Source: Clinical Prostate Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Kenji Makita Yasushi Hamamoto Hiromitsu Kanzaki Kei Nagasaki Katsuyoshi Hashine Source Type: research
mpMRI-targeted biopsy of the prostate in men ≥ 75 years. 7-year report from a high-volume referral center
CONCLUSION: After evaluation of a large patient cohort, we show that age≥75 years represents a significant risk factor for the detection of clinically significant prostate cancer. Further studies on mid- and long term outcome are necessary to draw conclusions for clinical decision making in this patient cohort.PMID:37718788 | DOI:10.3233/CH-238101
Source: Clinical Prostate Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Michael Chaloupka Nikolaos Pyrgidis Benedikt Ebner Paulo Pfitzinger Yannic Volz Elena Berg Benazir Abrarova Michael Atzler Troya Ivanova Paulo Pfitzinger Christian G Stief Maria Apfelbeck Dirk-Andr é Clevert Source Type: research
Bone marrow edema at ligament insertion is an accurate MRI sign of deltoid ligament injury
CONCLUSION: BMELI can reliably indicate concomitant injury to the DL in CAI patients. Using BMELI as a sign of chronic DL injury when ALMC is unclear may reduce the risk of a false negative diagnosis.PMID:37722764 | DOI:10.1177/02841851231197508
Source: Acta Radiologica - September 18, 2023 Category: Radiology Authors: Jiahui Tong Hong Li Hongyun Li Yinghui Hua Source Type: research
Assessment of brainstem function and haemodynamics by MRI: challenges and clinical prospects
Br J Radiol. 2023 Sep 18:20220940. doi: 10.1259/bjr.20220940. Online ahead of print.ABSTRACTMRI offers techniques for non-invasively measuring a range of aspects of brain tissue function. Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used to assess neural activity, based on the brain's haemodynamic response, while arterial spin labelling (ASL) MRI is a non-invasive method of quantitatively mapping cerebral perfusion. Both techniques can be applied to measure cerebrovascular reactivity (CVR), an important marker of the health of the cerebrovascular system. BOLD, ASL and CVR ...
Source: The British Journal of Radiology - September 18, 2023 Category: Radiology Authors: Owen Bleddyn Woodward Ian Driver Stefan Theodor Schwarz Emma Hart Richard Wise Source Type: research
Distinct serum GDNF coupling with brain structural and functional changes underlies cognitive status in Parkinson's disease
CONCLUSION: Our findings reveal that the topological features of brain networks and cortical thickness are altered in PD patients with cognitive deficits. The above change, accompanied by the serum GDNF, may have merit as a diagnosis marker for PD and, arguably, cognition status.PMID:37718594 | DOI:10.1111/cns.14461
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Chuanxi Tang Ruiao Sun Ke Xue Mengying Wang Sijie Liang Piniel Alphayo Kambey Mingyu Shi Changyu Wu Gang Chen Dianshuai Gao Source Type: research
Disentangling accelerated cognitive decline from the normal aging process and unraveling its genetic components: A neuroimaging-based deep learning approach
Conclusion Our deep learning model was demonstrated effective on extracting relevant neuroimaging features and predicting individual cognitive decline. We reported a novel variant (rs144614292) within the NELL1 gene. Our approach has the potential to disentangle accelerated cognitive decline from the normal aging process and to determine its related genetic factors, leveraging opportunities for early intervention.PMID:37720047 | PMC:PMC10503860 | DOI:10.21203/rs.3.rs-3328861/v1
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yulin Dai Yu-Chun Hsu Brisa S Fernandes Kai Zhang Xiaoyang Li Nitesh Enduru Andi Liu Astrid M Manuel Xiaoqian Jiang Zhongming Zhao Source Type: research
