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Specialty: Neurology
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Total 86952 results found since Jan 2013.
Tilt testing
Pract Neurol. 2023 Sep 19:pn-2023-003749. doi: 10.1136/pn-2023-003749. Online ahead of print.ABSTRACTTilt testing can help to diagnose unexplained syncope, by precipitating an episode during cardiac monitoring. The Italian protocol, now most widely used, involves giving sublingual nitroglycerine after 15 min, while monitoring beat-to-beat blood pressure (BP) and recording on video. Tilt testing is time-consuming but it is clinically useful and can guide therapy. Complications are rare. Syncope types include vasovagal syncope where BP falls after >3 min of tilt-up and later the heart rate falls; classic orthostatic hypot...
Source: Practical Neurology - September 19, 2023 Category: Neurology Authors: Paul N Cooper Richard Sutton Source Type: research
Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: An initial foray into a novel and non-pharmacological rehabilitative therapy
Exp Neurol. 2023 Sep 17:114544. doi: 10.1016/j.expneurol.2023.114544. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) causes neurobehavioral and cognitive impairments that negatively impact life quality for millions of individuals. Because of its pernicious effects, numerous pharmacological interventions have been evaluated to attenuate the TBI-induced deficits or to reinstate function. While many such pharmacotherapies have conferred benefits in the laboratory, successful translation to the clinic has yet to be achieved. Given the individual, medical, and societal burden of TBI, there is an urgent need for alte...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Eleni H Moschonas Tyler S Ranellone Vincent J Vozzella Piper L Rennerfeldt Corina O Bondi Ellen M Annas Rachel A Bittner Dana M Tamura Rithika I Reddy Rithik R Eleti Jeffrey P Cheng Jessica M Jarvis Ericka L Fink Anthony E Kline Source Type: research
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Exp Neurol. 2023 Sep 17:114545. doi: 10.1016/j.expneurol.2023.114545. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized at an early stage by memory alterations that worsen during the development of the disease. Several clinical trials in phase 3 have failed despite being able to counteract classical AD-related alterations, possibly because of the lack of recovery of the regular neuronal network activity essential for memory including low gamma oscillations (γ-Osc). Nowadays, Levetiracetam (LEV), an SV2A modulator approved for epilepsy, is being used in trials with AD patients without further support ...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Arturo G Isla Hugo Balleza-Tapia Fengna Chu Gefei Chen Janne Johansson Per Nilsson Andr é Fisahn Source Type: research
Role of S100 and YKL40 on Intraventricular Cerebral Hemorrhages in the Preterm Infant and the Neuroprotective Role of miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 in Neonatal Mice with Nerve Injury
CONCLUSION: Our findings demonstrate that miR-138-siRNAs-HIF-1a and miR-21-siRNAs-HVCN1 injections prevent cerebral ischemia-induced brain damage in hypoxia mice by increasing HVCN1 and HIF-1a and decreasing S100b, which in turn lessens apoptosis and epilepsy in hypoxic mice.PMID:37724672 | DOI:10.2174/0929867331666230915103147
Source: Epilepsy Curr - September 19, 2023 Category: Neurology Authors: Roghayeh Ijabi Zachary A Kaminsky Parisa Roozehdar Janat Ijabi Hemen Moradi-Sardareh King Hwa Ling Najmeh Tehranian Source Type: research
Correction to "A causative role for remote dural puncture and resultant arachnoid bleb in new daily persistent headache: A case report"
Headache. 2023 Sep;63(8):1198. doi: 10.1111/head.14609.NO ABSTRACTPMID:37723990 | DOI:10.1111/head.14609
Source: Headache - September 19, 2023 Category: Neurology Source Type: research
Correction to "Regional cerebral perfusion during the premonitory phase of triggered migraine: A double-blind randomized placebo-controlled functional imaging study using pseudo-continuous arterial spin labelling"
Headache. 2023 Sep;63(8):1199. doi: 10.1111/head.14610.NO ABSTRACTPMID:37723989 | DOI:10.1111/head.14610
Source: Headache - September 19, 2023 Category: Neurology Source Type: research
Changes in cognitive appraisal in a randomized controlled trial of mindfulness-based cognitive therapy for patients with migraine
CONCLUSION: In this study, pain catastrophizing showed strong promise as a potential mechanism of MBCT-M. Future research should continue to explore cognitive appraisal changes in mindfulness-based interventions.PMID:37723970 | DOI:10.1111/head.14627
Source: Headache - September 19, 2023 Category: Neurology Authors: Jessica A Kruse Elizabeth K Seng Source Type: research
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Exp Neurol. 2023 Sep 17:114545. doi: 10.1016/j.expneurol.2023.114545. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized at an early stage by memory alterations that worsen during the development of the disease. Several clinical trials in phase 3 have failed despite being able to counteract classical AD-related alterations, possibly because of the lack of recovery of the regular neuronal network activity essential for memory including low gamma oscillations (γ-Osc). Nowadays, Levetiracetam (LEV), an SV2A modulator approved for epilepsy, is being used in trials with AD patients without further support ...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Arturo G Isla Hugo Balleza-Tapia Fengna Chu Gefei Chen Janne Johansson Per Nilsson Andr é Fisahn Source Type: research
Effect of electrical and chemical (activation versus inactivation) stimulation of the infralimbic division of the medial prefrontal cortex in rats with chronic neuropathic pain
This study aimed to investigate the participation of the infralimbic division (IFL) of the mPFC in chronic NP, as well as the role of the N-methyl-D-aspartic acid receptor (NMDAr) in the elaboration of chronic NP. Male Wistar rats were submitted to the von Frey and acetone tests to assess mechanical and cold allodynia after 21 days of chronic constriction injury (CCI) of the sciatic nerve or Sham-procedure ("false operated"). Electrical neurostimulation of the IFL/mPFC was performed by low-frequency stimuli (20 μA, 100 Hz) applied for 15 s by deep brain stimulation (DBS) device 21 days after CCI. Either cobalt chloride (C...
Source: Brain Research - September 19, 2023 Category: Neurology Authors: Thais Lohanny Moura-Pacheco Renata Cristina Martins-Pereira Priscila Medeiros Louren ço Sbragia Christie Ramos Andrade Leite-Panissi H élio Rubens Machado Norberto Cysne Coimbra Renato Leonardo de Freitas Source Type: research
Acupuncture Improves Synaptic Plasticity of SAMP8 Mice through the RhoA/ROCK Pathway
CONCLUSION: Acupuncture can improve synaptic plasticity by inhibiting the abnormal activation of the RhoA/ROCK pathway, and improve the spatial learning and memory ability of AD, so as to achieve the purpose of treating AD.PMID:37723951 | DOI:10.2174/1567205020666230828095826
Source: Current Alzheimer Research - September 19, 2023 Category: Neurology Authors: Bohong Kan Zhengjia Dong Zhenyu Tang Lan Zhao Zhen Li Source Type: research
Further characterization of the neuro-endocrine phenotype associated with the PPOX-related variegate porphyria
Variegate porphyria is caused by mutations in the PPOX gene. It usually presents in adolescents and adults as an autosomal dominant condition, with cutaneous features or acute peripheral and/or central nervous system crises. A rarer variant, homozygous variegate porphyria, presents in childhood with cutaneous manifestations as well as and neurophenotypes.
Source: Pediatric Neurology - September 19, 2023 Category: Neurology Authors: Yousef A. Assaleh, Brahim Tabarki Tags: Short Communication Source Type: research
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention —part 2: flunarizine
ConclusionsPublished flunarizine trials predate the recommended endpoints for evaluating migraine prophylaxis drugs, hence the lack of an adequate assessment for these endpoints. Further, modern-day, large ‐scale studies would be valuable in re-evaluating the efficacy of flunarizine for the treatment of migraines, offering additional insights into its potential benefits.
Source: The Journal of Headache and Pain - September 19, 2023 Category: Neurology Source Type: research
Neurological telerehabilitation in the COVID-19 era – current perspectives through a bibliometric analysis
ConclusionA greater interest in the subject was observed in China with greater relevance of journals and institutions focused on neurology. However, despite telerehabilitation being an effective alternative in the context of the pandemic, few studies have explored this modality.
Source: Frontiers in Neurology - September 19, 2023 Category: Neurology Source Type: research
Secondary surgical procedures following motor nerve injuries
CONCLUSIONS: Secondary surgical procedures are a valuable option for functional reconstruction after nerve injury.PMID:37721574 | DOI:10.1007/s00115-023-01543-y
Source: Der Nervenarzt - September 18, 2023 Category: Neurology Authors: Johannes Heinzel Cosima Prahm Henrik Lauer Adrien Daigeler Helene Hurth Martin Schuhmann Jonas Kolbenschlag Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Brain Research Bulletin - September 18, 2023 Category: Neurology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
