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Survival, Recurrence, and Function After Epiphyseal Preservation and Allograft Reconstruction in Osteosarcoma of the Knee.
CONCLUSIONS: Although the recurrence rate was high in this series, the small sample size means that even one or two fewer recurrences might have resulted in a much more favorable percentage. Because of this, future, larger studies will need to determine whether this is a safe approach, and perhaps should compare epiphyseal preservation with other possible approaches, including endoprosthetic reconstruction and/or osteoarticular allografts.
LEVEL OF EVIDENCE: Level IV, therapeutic study.
PMID: 25352262 [PubMed - as supplied by publisher]
Source: Clinical Orthopaedics and Related Research - October 29, 2014 Category: Orthopaedics Authors: Aponte-Tinao L, Ayerza MA, Muscolo DL, Farfalli GL Tags: Clin Orthop Relat Res Source Type: research
Abstract 550: Genomic instability and telomere characteristics as predictive biomarkers of therapeutic response in triple-negative breast cancer
Background. Triple negative breast cancers (TNBC) represent about 15 % of invasive breast carcinomas. These tumors are identified in clinical practice according to their “triple negative” immunophenotype (estrogen receptor, progesterone receptor and HER2 negative). TNBC show aggressive behavior and an unusual sarcoma-like pattern of metastasis. Identification of predictive biomarkers is critical to optimal therapeutic management of these tumors. TNBC are characterized by increased genomic instability. These tumors present complex pattern of numerous low-amplitude genomic gains and losses as well as shorter telomeres.
A...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Gay-bellile, M., Radosevic-Robin, N., Eymard-Pierre, E., Kwiatkowski, F., Dauplat, M., Privat, M., Abrial, C., Combes, P., Soler, G., Bignon, Y.-J., Nabholtz, J.-M., Vago, P., Penault-Llorca, F., Tchirkov, A. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1723: Effect and mechanism of PF299804 alone and in combination with STAT3 inhibitor in human sarcoma cell lines
Conclusion: Although the second generation irreversible pan-HER inhibitor PF299804 inactivated HER family and downstream pathways, it encountered resistance at least partially due to the STAT3 activation. Therefore, addition of STAT3 inhibitor in PF299804 therapy may block STAT3 activation and achieve synergistic anti-proliferation in sarcoma cell lines.
Citation Format: Xiaochun Wang, David Goldstein, Philip Crowe, Jia-Lin Yang. Effect and mechanism of PF299804 alone and in combination with STAT3 inhibitor in human sarcoma cell lines. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Wang, X., Goldstein, D., Crowe, P., Yang, J.-L. Tags: Experimental and Molecular Therapeutics Source Type: research
Sy8-1 * the present and perspective in breast cancer study groups of jcog
The mission of Japan Clinical Oncology Group (JCOG) is development the standard treatment for each 17 specific cancers according to several clinical trials based on public fund. These funds were obtained from Cancer Development Fund 26-A-4 and competitive funds of The Ministry of Health. The history of Breast Cancer Study Group (BCSG) is old and have been continued for about 30 years since the dawn of JCOG. Currently, BCSG consist of 36 institutions from the whole country. There are strict rules to increase the participating sites. We have performed 15 clinical trials (11: metastatic and advanced breast cancer, 3: adjuvant...
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Iwata, H., Inoue, K. Tags: Symposium 8: ' The present and perspective in breast cancer study groups in Japan Source Type: research
Prediction of neoadjuvant radiation chemotherapy response and survival using pretreatment 18 FFDG PET/CT scans in locally advanced rectal cancer
Conclusion
Metabolic and textural parameters from initial [18F]FDG PET/CT scans could be indexes to assess tumour heterogeneity for the prediction of neoadjuvant radiation chemotherapy response and recurrence in LARC.
Source: European Journal of Nuclear Medicine and Molecular Imaging - September 4, 2015 Category: Nuclear Medicine Source Type: research
Diagnosis and Treatment of Nasopharyngeal Carcinoma in Children and Adolescents – Recommendations of the GPOH-NPC Study Group
Klin Padiatr 2016; 228: 105-112DOI: 10.1055/s-0041-111180Nasopharyngeal carcinoma (NPC) is a rare malignant tumor arising from epithelial cells of the nasopharynx. Its incidence is highest in Southeast Asia. Age distribution of NPC is bimodal, with one peak in young adolescents and another in patients 55–59 years of age. EBV appears to be the primary etiologic agent in the pathogenesis, environmental factors such as nitrosamines and genetic factors are contributory. NPC is most commonly diagnosed in locally advanced stages, with lymph node metastases occurring in up to 90% of patients. About 5–10% of patients present w...
Source: Klinische Padiatrie - May 1, 2016 Category: Pediatrics Authors: Kontny, U.Franzen, S.Behrends, U.Bührlen, M.Christiansen, H.Delecluse, H.Eble, M.Feuchtinger, T.Gademann, G.Granzen, B.Kratz, C. P.Lassay, L.Leuschner, I.Mottaghy, F. M.Schmitt, C.Staatz, G.Timmermann, B.Vorwerk, P.Wilop, S.Wolff, H. A.Mertens, R. Tags: Diagnostic and Treatment Recommendation Source Type: research
Focal adhesion kinase: predictor of tumour response and risk factor for recurrence after neoadjuvant chemoradiation in rectal cancer
This study includes 73 patients with locally advanced rectal cancer receiving standard neoadjuvant CRT followed by total mesorectal excision. Focal adhesion kinase protein levels were immunohistochemically analysed in the pre‐treatment biopsies of these patients and correlated with tumour response to CRT and patients survival. Low FAK expression was significantly correlated with local and distant recurrence (P = 0.013). Low FAK expression was found to be a predictive marker of tumour response to neoadjuvant therapy (P = 0.007) and patients whose tumours did not express FAK showed a strong association with lower disea...
Source: Journal of Cellular and Molecular Medicine - April 30, 2016 Category: Molecular Biology Authors: Teresa Gómez del Pulgar, Arancha Cebrián, Maria Jesús Fernández‐Aceñero, Aurea Borrero‐Palacios, Laura Puerto‐Nevado, Javier Martínez‐Useros, Juan Pablo Marín‐Arango, Cristina Caramés, Ricardo Vega‐Bravo, María Rodríguez‐Remírez, Tags: Original Article Source Type: research
Outcome and Salvage Surgery Following “Watch and Wait” for Rectal Cancer after Neoadjuvant Therapy: A Systematic Review
CONCLUSION: The majority of patients with tumor regrowth can be salvaged with definite surgery after “watch and wait.” However, there is insufficient evidence to draw firm conclusions on the oncological safety of this approach; therefore, it is currently not the standard of care for locally advanced rectal cancer.
Source: Diseases of the Colon and Rectum - February 11, 2017 Category: Gastroenterology Tags: Current Status Source Type: research
Usefulness of lymphocyte-to-monocyte, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratios as prognostic markers in breast cancer patients treated with neoadjuvant chemotherapy
ConclusionHigh LMR and low NLR can be considered as favourable prognostic factors in BC patients treated with nCT.
Source: Clinical and Translational Oncology - August 7, 2017 Category: Cancer & Oncology Source Type: research
Analysis of the relevance between molecular subtypes and efficacy of neoadjuvant chemotherapy in breast cancer as well as its prognostic factors
ConclusionsThe pCR was more frequently observed in HER2 overexpression type and Triple negative type of breast cancer. That could achieve a higher rate of pCR on paclitaxel class joint anthracycline-based chemotherapy. But Triple negative type showed worse prognosis, due to residual tumor after neoadjuvant chemotherapy, which could be in combination or sequential, at the neoadjuvant / adjuvant setting (NCCN 2016 Breast cancer, chemotherapy regimens), So how to choose a more appropriate neoadjuvant chemotherapy regimens, we should need further research.
Source: Pathology Research and Practice - July 5, 2018 Category: Pathology Source Type: research
No. 370-Management of Squamous Cell Cancer of the Vulva.
Authors: Francis JA, Eiriksson L, Dean E, Sebastianelli A, Bahoric B, Salvador S
Abstract
OBJECTIVE: This guideline reviews the clinical evaluation and management of squamous cell cancer (SCC) of the vulva with respect to diagnosis, primary surgical, radiation, or chemotherapy management and need for adjuvant treatment with chemotherapy and/or radiation therapy. Other vulvar cancer pathologic diagnoses are not included in the guideline.
INTENDED USERS: The first part of this document which includes recommendations 1 through 3 is for general gynaecologists, obstetricians, family doctors, registered nurses, nurse...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - December 26, 2018 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Mesothelioma Treatment Combines Proton and Photodynamic Therapy
Intraoperative photodynamic therapy combined with novel proton radiation improved survival time significantly for recent patients with advanced-stage pleural mesothelioma.
The study — the first to measure the impact of this combination — involved 10 consecutive patients treated at the University of Pennsylvania’s Abramson Cancer Center.
The treatment regimen resulted in a 90 percent, two-year disease control rate and an impressive 30.3-month median overall survival from the time of diagnosis.
All 10 patients were diagnosed before treatment began with stage 3 or stage 4 disease, which typically results in a 10 to 14-m...
Source: Asbestos and Mesothelioma News - March 12, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news
Neoadjuvant Chemotherapy Use for Nonmetastatic Breast Cancer at Five Public South African Hospitals and Impact on Time to Initial Cancer Therapy
Conclusion.NAC use for BC at these South African hospitals was associated with both tumor characteristics and heterogenous resource constraints.Implications for Practice.Using data from a large breast cancer cohort treated in South Africa's public healthcare system, the authors looked at determinants of neoadjuvant chemotherapy use and time to initiate treatment. It was found that neoadjuvant chemotherapy was associated with increasing tumor burden and aggressive molecular subtypes, demonstrating clinically appropriate care in a lower resource setting. Results of this study also showed that time to treatment differences be...
Source: The Oncologist - July 16, 2019 Category: Cancer & Oncology Authors: Daniel S. O'Neil, Sarah Nietz, Ines Buccimazza, Urishka Singh, Sharon Čačala, Laura W. Stopforth, Maureen Joffe, Judith S. Jacobson, Alfred I. Neugut, Katherine D. Crew, Paul Ruff, Herbert Cubasch Tags: Breast Cancer, Health Outcomes and Economics of Cancer Care, Global Health and Cancer Source Type: research
Connection and distinction of tumor regression grading systems of gastrointestinal cancer.
CONCLUSIONS: The tumor regression grading system is useful in evaluating tumor response to neoadjuvant therapy, but more work is needed to refine and unify the system.
PMID: 32825946 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - August 24, 2020 Category: Pathology Authors: Tong Y, Liu D, Zhang J Tags: Pathol Res Pract Source Type: research
