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Our Case Against Google
As many of our readers know, Medgadget has been in existence since 2004. That’s fourteen years dedicated to bringing you the latest medical technology news, FDA approvals, exclusive interviews, product reviews, reports from conferences, and special...
Source: Medgadget - March 1, 2018 Category: Medical Devices Authors: Editors Tags: Exclusive News Source Type: blogs

Fight Aging! Newsletter, March 25th 2019
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - March 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Meta-Analysis of the Effects of Foam Rolling on Performance and Recovery
Conclusion In conclusion, this meta-analysis illustrates that pre-rolling seems to be an effective strategy for short-term improvements in flexibility without decreasing muscle performance. The review has also shown that the improvement of sprint performance to be expected from the use of pre-rolling, as well as the recovery rate of the performance measures of speed and strength with post-rolling, are significant enough to be relevant for at least elite athletes. The underlying mechanisms, however, remain elusive and the effects are in part contradictory. While the effects of FR on muscle function were less clear, the pos...
Source: Frontiers in Physiology - April 8, 2019 Category: Physiology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

The Interplay Between Lymphatic Vessels and Chemokines
Conclusions Lymphatic vessels, like blood vessels, are a highly interactive surface for cells of the immune system, and through the use of chemokines and their receptors can coordinate key interactions. These pathways can control the entry and function of particular immune subsets in a number of pathological conditions. Nonetheless LECs have distinct patterns of chemokine secretion and expression of chemokine receptors that distinguish them from the blood vessel system and mediate distinct roles and responses. The abundance and diversity of the chemokine family point to the likelihood that a plethora of novel chemokine fu...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Acupuncture for Post-stroke Shoulder-Hand Syndrome: A Systematic Review and Meta-Analysis
Conclusions: Acupuncture therapy seems effective for motor function, pain relief and activities of daily living in stroke patients with mild SHS, when it is used in combination with rehabilitation. The low certainty of evidence downgrades our confidence in making recommendations to clinical practice. Introduction Shoulder-hand syndrome (SHS) is a common condition among people who have had a stroke, with its reported prevalence ranging from 12% to 49% (1, 2). The main symptoms of SHS include pain, hyperalgesia, joint swelling and limitations in range of motion (ROM) (3). Post-stroke SHS is also named type I complex ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Subclinical Lesions of the Primary Clinical Target Volume Margin in Esophageal Squamous Cell Carcinoma and Association With FDG PET/CT
Conclusions: To cover 94.5% of ESCC subclinical lesions in the CTVp, a 3-cm margin along the cranial-caudal axis should be added to the primary gross tumor volume as defined by FDG-PET/CT, as well as a cutoff SUVmax value of 2.5. Although preoperative FDG PET/CT images may not reveal lesions directly, the SUVmax and MTV measurements together could predict their presence. Background Esophageal carcinoma often occurs as squamous cell carcinoma (ESCC), a highly aggressive malignancy with a poor prognosis worldwide. The incidence rates of ESCC are particularly high in China (1). Most patients with ESCC have locally adv...
Source: Frontiers in Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research

Cohort study examining the relationship between remoteness and requirement for surgery to treat peripheral artery disease at a tertiary hospital in North Queensland
CONCLUSIONS: People with PAD in North Queensland residing furthest from the tertiary hospital presented with more severe artery disease and had greater rates of PAD surgery.PMID:34346526 | DOI:10.1111/ajr.12776
Source: The Australian Journal of Rural Health - August 4, 2021 Category: Rural Health Authors: Jonathan Golledge Aaron Drovandi Ramesh Velu Joseph Moxon Source Type: research

Relationship between life-time exposure to ambient fine particulate matter and carotid artery intima-media thickness in Australian children aged 11-12 years
This study examined whether childhood exposure to air pollutants was related to a marker of cardiovascular risk, carotid intima-media thickness (CIMT) in children aged 11-12 years old. Longitudinal Study of Australian Children (LSAC) recruited parents and their children born in 2003-4. Among the participants, CheckPoint examination was conducted when the children were 11-12 years old. Ultrasound of the right carotid artery was performed using standardized protocols. Average and maximum far-wall CIMT, carotid artery distensibility, and elasticity were quantified using semiautomated software. Annual and life-time exposure to...
Source: Environmental Pollution - September 30, 2021 Category: Environmental Health Authors: Yue Leon Guo Rosario D Ampon Ivan C Hanigan Luke D Knibbs Christy Geromboux Ta-Chen Su Kazuaki Negishi Leanne Poulos Geoffrey G Morgan Guy B Marks Bin Jalaludin Source Type: research

Endodontic Microbiology: A Bibliometric Analysis of the Top 50 Classics
CONCLUSIONS: The present study provided a detailed list of the top 50 most cited and classic articles on microbiology in endodontics. This will help researchers, students, and clinicians in the field of endodontics as an impressive source of information.PMID:34746305 | PMC:PMC8570872 | DOI:10.1155/2021/6657167
Source: Biomed Res - November 8, 2021 Category: Research Authors: Mohmed Isaqali Karobari Manahil Maqbool Paras Ahmad Muqthadir Siddiqui Mohammed Abdul Anand Marya Adith Venugopal Gul Muhammad Shaik Giuseppe Alessandro Scardina Pietro Messina Tahir Yusuf Noorani Source Type: research

Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
CONCLUSIONS: This update identified no new eligible studies and the conclusions remain the same. VAS is associated with a clinically meaningful reduction in morbidity and mortality in children. Further placebo-controlled trials of VAS in children between six months and five years of age would not change the conclusions of this review, although studies that compare different doses and delivery mechanisms are needed. In populations with documented VAD, it would be unethical to conduct placebo-controlled trials.PMID:35294044 | PMC:PMC8925277 | DOI:10.1002/14651858.CD008524.pub4
Source: Cochrane Database of Systematic Reviews - March 16, 2022 Category: General Medicine Authors: Aamer Imdad Evan Mayo-Wilson Maya R Haykal Allison Regan Jasleen Sidhu Abigail Smith Zulfiqar A Bhutta Source Type: research