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Total 139632 results found since Jan 2013.

TMEM98, a novel secretory protein, promotes endothelial cell adhesion as well as vascular smooth muscle cell proliferation and migration.
Abstract Transmembrane protein 98 (TMEM98) is a novel gene. In a prior study, we have shown that siRNA-mediated knockdown of TMEM98 inhibited interleukin (IL)-8-promoted endothelial cell (EC) adhesion as well as vascular smooth muscle cell (VSMC) proliferation and migration in the vascular endothelial and smooth muscle cells dysfunction. Herein, we used gain- and loss-of-function approaches combined with biochemical techniques to further explore the role of TMEM98 in the vascular wall cell. The expression and secretion of TMEM98 was increased in cultured human umbilical vein endothelial cells (HUVECs) and VSMCs tr...
Source: Canadian Journal of Physiology and Pharmacology - September 4, 2020 Category: Drugs & Pharmacology Authors: Li M, Zhu H, Hu X, Gao F, Hu X, Cui Y, Wei X, Xie C, Lv G, Zhao Y, Gao Y Tags: Can J Physiol Pharmacol Source Type: research

Is It Too Much to Request a Formal Neurology Consultation After Thoracic Endovascular Aortic Aneurysm Repair?
SPINAL cord ischemia (SCI) after thoracic endovascular aortic aneurysm repair (TEVAR) is defined as the development of a new in-hospital neurologic deficit or paralysis not attributable to intracranial disease and can be further classified as permanent (no recovery of neurologic deficit before discharge) or transient (recovery of neurologic deficit before discharge).1 SCI after TEVAR is a devastating complication associated with significantly increased morbidity and mortality. The Society for Vascular Surgery created a registry known as the Vascular Quality Initiative (VQI), which contains data from vascular procedures per...
Source: Journal of Cardiothoracic and Vascular Anesthesia - October 2, 2020 Category: Anesthesiology Authors: Hamdy Awad, Gabriel Alcodray, Hesham Kelani, Michael Essandoh Tags: Letter to the Editor Source Type: research

Micro-RNA Regulation of Vascular Smooth Muscle Cells and Its Significance in Cardiovascular Diseases.
Abstract Cardiovascular disease (CVD) is among the leading causes of death worldwide. Micro-RNAs (miRNAs), regulatory molecules that repress protein expression, have attracted considerable attention in CVD research. The vasculature plays a big role in CVD development and progression and dysregulation of vascular cells underlies the root of many vascular diseases. This review provides a brief introduction of the biogenesis of miRNAs and exosomes, followed by overview of the regulatory mechanisms of miRNAs in vascular smooth muscle cells (VSMCs) intracellular signaling during phenotypic switching, senescence, calcif...
Source: Canadian Journal of Physiology and Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Authors: Nguyen DND, Chilian WM, Zain SM, Daud MF, Pung YF Tags: Can J Physiol Pharmacol Source Type: research

Intravitreal anti-vascular endothelial growth factor versus panretinal LASER photocoagulation for proliferative diabetic retinopathy: A systematic review and meta-analysis
CONCLUSIONS: This meta-analysis of the available evidence in patients with early PDR demonstrates a potential benefit for anti-VEGF over PRP alone. However, these benefits must be weighed against the relative costs of treatment and the potential risks of loss to follow-up.PMID:33631120 | DOI:10.1016/j.jcjo.2021.01.017
Source: Canadian Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: William B Yates Zaid Mammo Matthew P Simunovic Source Type: research

Intravitreal anti-vascular endothelial growth factor versus panretinal LASER photocoagulation for proliferative diabetic retinopathy: a systematic review and meta-analysis
CONCLUSIONS: This meta-analysis of the available evidence in patients with early PDR demonstrates a potential benefit for anti-VEGF over PRP alone. However, these benefits must be weighed against the relative costs of treatment and the potential risks of loss to follow-up.PMID:33631120 | DOI:10.1016/j.jcjo.2021.01.017
Source: Canadian Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: William B Yates Zaid Mammo Matthew P Simunovic Source Type: research

Adoption of peer review of literature search strategies in knowledge synthesis from 2009 to 2018: An overview
ConclusionDespite its value, adoption of PRESS appears low. Advocacy for, and education about, PRESS may be required.
Source: Health Information and Libraries Journal - March 14, 2021 Category: Databases & Libraries Authors: Christine J. Neilson Tags: REVIEW Source Type: research

Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia
Can J Physiol Pharmacol. 2021 May 5. doi: 10.1139/cjpp-2021-0143. Online ahead of print.ABSTRACTObstructive sleep apnea (OSA) is a chronic condition characterized by chronic intermittent hypoxia (IH) and is associated with cardiovascular (CVD) and chronic kidney diseases (CKD). Patients with OSA haveincreased biomarkers of aging such as telomere shortening. We used PCR to report shortened telomere lengths in aortic and renal tissues from mice exposed to 8 weeks of IH. Our data indicates that IH, a hallmark of OSA, accelerates vascular and renal aging that may contribute to OSA-induced CVD and CKD.PMID:33951396 | DOI:10.1139/cjpp-2021-0143
Source: Canadian Journal of Physiology and Pharmacology - May 5, 2021 Category: Drugs & Pharmacology Authors: Mohammad Badran Bisher Abuyassin Najib Ayas Don D Sin Ismail Laher Source Type: research