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Drug: Metformin
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Total 2318 results found since Jan 2013.
New insights on the potential anti-epileptic effect of metformin: Mechanistic pathway
In conclusion, metformin might be an adjuvant with AEAs in the management of refractory epilepsy. Preclinical and clinical studies are warranted in this regard.PMID:37737447 | DOI:10.1111/jcmm.17965
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Saud A Alnaaim Hayder M Al-Kuraishy Ali I Al-Gareeb Naif H Ali Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research
The Associations Between Diabetes and Metformin and Abdominal Aortic Aneurysm (AAA) Events: A Retrospective Cohort Study
The aim of this study was to determine, among persons 66 years of age or older, the associations between no diabetes, diabetes and metformin, and diabetes and no metformin and abdominal aortic aneurysm (AAA) events.
Source: Journal of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Peter Brown, Susan Brogly, David Zelt, Michael Yacob, Wenbin Li, Joan Tranmer Tags: Session V: Vascular Medicine Source Type: research
The Relationship between Metformin Consumption and Cancer Risk: An Updated Umbrella Review of Systematic Reviews and Meta ‑Analyses
Conclusions: Treatment with metformin can significantly decrease the chance of all cancers with larger preventive effect on hepatocellular carcinoma and smaller preventive effect on lung and breast cancers.
Source: International Journal of Preventive Medicine - September 19, 2023 Category: International Medicine & Public Health Source Type: research
The correlation between vitamin B12 and folate levels and bone mineral density among the Saudi population in a primary care setting
CONCLUSION: Vitamin B12 is associated with fracture risk; however, vitamin B12 and folate levels are not correlated to BMD (femoral neck and lumbar spine).PMID:37636170 | PMC:PMC10451589 | DOI:10.4103/jfmpc.jfmpc_1209_22
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Sarah I Bin Hussain Abdullah AlKhenizan Ahmed Mahmoud Hussain Qashlaq Source Type: research
The Effect of Metformin on Triple-Negative Breast Cancer Cells and Nude Mice
This study delves deeper into the impact of metformin on TNBC by examining changes in proliferation, apoptosis, invasion, migration, and adhesion of TNBC cells, specifically MDA-MB-231, post-metformin exposure. The treatment of MDA-MB-231 with metformin in immunodeficient nude mice led to discernible changes in tumor metrics such as size, weight, lymph node engagement, and angiogenesis. Post-treatment, MDA-MB-231 cells exhibited a marked decline in proliferation, invasion, migration, and adhesion, alongside a significant rise in apoptosis. In the in vivo model with nude mice, tumors displayed notable reductions in size and...
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Jin Song Junfeng Du Lili Han Xue Lin Cibo Fan Gang Chen Source Type: research
Risk factors and drug discovery for cognitive impairment in type 2 diabetes mellitus using artificial intelligence interpretation and graph neural networks
ConclusionThe method based on Interpreting AI and GNN can identify the risk factors and potential drugs associated with T2DM-CI.
Source: Frontiers in Endocrinology - August 25, 2023 Category: Endocrinology Source Type: research
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia
EMBO Mol Med. 2023 Aug 23:e16908. doi: 10.15252/emmm.202216908. Online ahead of print.ABSTRACTPeriventricular neuronal heterotopia (PH) is one of the most common forms of cortical malformation in the human cortex. We show that human neuronal progenitor cells (hNPCs) derived from PH patients with a DCHS1 or FAT4 mutation as well as isogenic lines had altered migratory dynamics when grafted in the mouse brain. The affected migration was linked to altered autophagy as observed in vivo with an electron microscopic analysis of grafted hNPCs, a Western blot analysis of cortical organoids, and time-lapse imaging of hNPCs in the p...
Source: Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Cedric Bressan Marta Snapyan Marina Snapyan Johannes Klaus Francesco di Matteo Stephen P Robertson Barbara Treutlein Martin Parent Silvia Cappello Armen Saghatelyan Source Type: research
Identification of clinical and pharmacogenetic factors influencing metformin response in Type 2 diabetes mellitus
Pharmacogenomics, Ahead of Print.
Source: Future Medicine: Pharmacogenomics - August 23, 2023 Category: Genetics & Stem Cells Authors: Noelia P érez-Gómez Mar ía Dolores Fernández-Ortega Miren Elizari-Roncal Estefan ía Santos-Mazo Laura de la Maza-Pereg Sara Calvo Raquel Alcaraz Antonio Sanz-Solas Raquel Vinuesa Miriam Saiz-Rodr íguez Source Type: research
The role of immunosuppressive myofibroblasts in the aging process and age-related diseases
J Mol Med (Berl). 2023 Aug 22. doi: 10.1007/s00109-023-02360-1. Online ahead of print.ABSTRACTTissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to adapt to the changes in the microenvironment and thus maintain tissue homeostasis. Several stresses, also those associated with the aging process, convert quiescent fibroblasts into myofibroblasts which not only display fibrogenic properties but also act as immune regulators cooperating both with tissue-resident immune cells and those immune cells r...
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: Antero Salminen Source Type: research
Adding empagliflozin to sitagliptin plus metformin vs. adding sitagliptin to empagliflozin plus metformin as triple therapy in Egyptian patients with type 2 diabetes: a 12-week open trial
CONCLUSIONS: Empagliflozin was superior to sitagliptin in relation to glycemic control, weight, and systolic/diastolic blood pressure reduction.PMID:37606137 | DOI:10.26355/eurrev_202308_33300
Source: Molecular Medicine - August 22, 2023 Category: Molecular Biology Authors: H G Zakaraia H F Salem M A A Mostafa A M Ali H Rabea Source Type: research
