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Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

The need to emphasize nephrology knowledge in residents-in-training
Conclusion: Residency offers a golden opportunity for resident physicians to create a strong foundation of concepts in medicine. There are several basic areas in the field of nephrology that need to be further emphasized during residency training to help improve patient care and potentially decrease the incidence of AKI.
Source: North American Journal of Medical Sciences - November 27, 2015 Category: Journals (General) Authors: Sana R AkbarHafiz I IqbalUmair Ahmed Source Type: research

Transforming Cancer Prevention
We have entered a transformative period in cancer prevention (including early detection). Remarkable progress in precision medicine and immune-oncology, driven by extraordinary recent advances in genome-wide sequencing, big-data analytics, blood-based technologies, and deep understanding of the tumor immune microenvironment (TME), has provided unprecedented possibilities to study the biology of premalignancy. The pace of research and discovery in precision medicine and immunoprevention has been astonishing and includes the following clinical firsts reported in 2015: driver mutations detected in circulating cell-free DNA in...
Source: Cancer Prevention Research - January 6, 2016 Category: Cancer & Oncology Authors: Kensler, T. W., Spira, A., Garber, J. E., Szabo, E., Lee, J. J., Dong, Z., Dannenberg, A. J., Hait, W. N., Blackburn, E., Davidson, N. E., Foti, M., Lippman, S. M. Tags: Special Report Source Type: research

The Diabetes Prevention Program: An Einstein Success Story
By Dr. Allen M. Spiegel Reading a March 30, 2016 article in the New York Times, "The Quiet Research That Led to a Resounding Success in Diabetes Prevention," transported me back in time and place to an interview I did at the Fox News TV studio in New York City in August 2001. At the time, I served as the director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH). The Diabetes Prevention Program (DPP), a randomized, multi-center clinical trial, was launched by NIDDK in 1995 to determine whether an intensive life-style intervention involving changes in...
Source: Healthy Living - The Huffington Post - April 5, 2016 Category: Consumer Health News Source Type: news

A Significant Injury with Just a Speck of Pain
​BY ARJUN BHARADWAJ & KHALID MALIK, MDA 58-year-old man who lived at a nursing facility came to the emergency department complaining of abdominal pain for three days. His pain was localized to the epigastrium and periumbilical regions. The nursing home staff indicated that he was hypotensive and possibly hypoxic.The patient said he never had similar pain before, which he said pain was mild and constant in severity and did not radiate to the chest, back, pelvis, or shoulders. He also reported nausea but no trauma, falls, vomiting, fever, chills, dizziness, chest pain, shortness of breath, trouble walking, or change in...
Source: The Case Files - October 16, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

The comparison of fennel infusion plus dry cupping versus metformin in management of oligomenorrhoea in patients with polycystic ovary syndrome: a randomised clinical trial.
Authors: Mokaberinejad R, Rampisheh Z, Aliasl J, Akhtari E Abstract Oligomenorrhoea treatment with hormone therapy and Metformin is not usually well tolerated and is associated with a broad range of side effects. In Persian medicine, the management of oligomenorrhoea can be done with fennel and dry cupping. A clinical trial was conducted on 61 patients with oligomenorrhoea. The patients randomly received treatment for 6 months in two groups: fennel infusion plus dry cupping (Group A); versus treatment with Metformin (Group B). On the days between the two periods, the patients' BMI, pain levels and side effects we...
Source: Journal of Obstetrics and Gynaecology - March 13, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Incretins and SGLT-2i Therapy of Type 2 Diabetes – Real Life Study of Their Therapeutic and Economic Effects
Conclusion: Incretins [dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide 1 receptor agonists (GLP-1 RA)] and sodium-glucose linked transporter-2 inhibitors (SGLT-2i) therapy steadily decreases the HbA1c level, and risk of developing diabetic incidents is reduced to between 333 and 465 cases among 6122 treated patients. Avoided cost for therapy of diabetes incidents account for between 305 and 510 thousand BGN. Introduction Incretin (DPP-4i and GLP-1 RA) and SGLT-2i groups are now routinely used for type 2 diabetes therapy and comprise a large number of medicinal products (Cheung et al., 2009; Lov...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Can I use DOAC in a patient with renal disease?
Case A 76-year-old man is diagnosed with non-valvular atrial fibrillation. His comorbid conditions are hypertension, diabetes complicated by neuropathy, and chronic kidney disease stage 3. His current medications include metformin, lisinopril, gabapentin, and aspirin. His most recent laboratories showed a creatinine 1.8, creatinine clearance (CrCl) 35 mL/min, hemoglobin 11g/dL, and international normalized ratio 1.0. His congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex (CHADSVASc) score is 4. Which medication should we use to prevent stroke in this patient?  Brief overview of the is...
Source: The Hospitalist - February 3, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Renal & Genitourinary Source Type: research

Should You Take an Antiviral to Prevent Long COVID?
The only guaranteed way to prevent Long COVID is to avoid getting infected by SARS-CoV-2, the virus that causes COVID-19. Recently, however, researchers have found promising signs that certain drugs may reduce the risk of developing Long COVID if they’re taken shortly after infection. Those studies are preliminary, but they raise an intriguing question: Should everyone who gets COVID-19 take medication in hopes of avoiding Long COVID? Here’s what experts say. Which drugs might prevent Long COVID? Studies have recently highlighted two promising drugs: Paxlovid and metformin. Paxlovid is an antiviral authorized t...
Source: TIME: Health - March 23, 2023 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID Questions COVID-19 healthscienceclimate Source Type: news

Researchers unlock new answers in quest for safer, more effective opioid therapy
A University of Arizona Health Sciences study uncovered new ways in which Hsp90-inhibitor drugs in the spinal cord are showing promise as potential pain therapeutics. Today University of Arizona Health Sciencesnhg-042920_opioid_research_4516-hero-web.jpg New research led by John Streicher provides additional insight into one of the foundational mechanisms that supports the role of Hsp90 in pain relief, and the findings may open the door for increased effectiveness and lower dosage of opioids. Noelle Haro-Gomez/University of Arizona Health SciencesHealthAdaptationCollege of Medicine - TucsonDeterminationExpertsExplora...
Source: The University of Arizona: Health - April 19, 2023 Category: Universities & Medical Training Authors: mittank Source Type: research

Most-Used Diabetes Drug Works in Different Way than Previously Thought
January 7, 2013 (Perelman School of Medicine) — A team, led by senior author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, found that the diabetes drug metformin works in a different way than previously understood. read more
Source: Diabetes News from dLife.com - January 9, 2013 Category: Consumer Health News Authors: dlife Source Type: news

Could exercise be as effective as medication?
Conclusion The researchers found that there are very few trials that directly compare exercise with drug therapy for any condition. They were only able to find enough trials to be able to analyse results for four major conditions. They found that exercise reduced death rates for people after a stroke (although this analysis has limitations and should be interpreted cautiously), and that drug therapy with diuretics improved death rates for people with heart failure. They did not find any difference between exercise and drug therapy for death rates after a heart attack or in people with pre-diabetes. There were several limit...
Source: NHS News Feed - October 2, 2013 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Medication Source Type: news

Metformin - Take it Right and Prevent Side Effects
Last week, one of my patients abruptly stopped taking his Metformin without alerting his physician or anyone else. He was having diarrhea and stomach cramps and thought it would be best to just stop his medicine. Diabetes is tough enough as it is - the last thing you need is to have unbearable side effects of a medication. But you shouldn't stop taking a medicine without telling anyone. Metformin should be taken with food - it helps to ease stomach discomfort and food helps with its absorption. My patient was taking Metformin on an empty stomach. We talked about how and when to take it during our session - he opted to give...
Source: About Diabetes - May 12, 2014 Category: Consumer Health News Source Type: news

Drug that can prevent the onset of diabetes is rarely used
Few doctors are prescribing a low-cost drug that has been proven effective in preventing the onset of diabetes, according to a UCLA study. The study, published in the peer-reviewed journal Annals of Internal Medicine, found that only 3.7 percent of U.S. adults with pre-diabetes were prescribed metformin during a recent three-year period. Metformin and lifestyle changes both can prevent the onset of diabetes, but people often struggle to adopt healthier habits, according to Dr. Tannaz Moin, the study’s lead author and an assistant professor of medicine in the division of endocrinology at the David Geffen School of Medicin...
Source: UCLA Newsroom: Health Sciences - April 29, 2015 Category: Universities & Medical Training Source Type: news

Vitamin That Prevents Diabetes
Researchers have discovered a direct link between low vitamin D3 levels and insulin resistance, pre-diabetes and full-blown type 2 diabetes.1 The study, which came out of Harbin Medical University in China, also revealed that even with a minor vitamin D3 deficiency, your risk of developing type 2 diabetes increases by 91%.2 I’m not surprised. It’s a connection I’ve seen with my patients for many years at the Sears Institute for Anti-Aging Medicine. Diabetes can be prevented — and conquered — through the healing power of vitamin D3. This fat-soluble vitamin is one of the core “primal”&nbs...
Source: Al Sears, MD Natural Remedies - May 17, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news