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Drug: Metformin

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Total 7110 results found since Jan 2013.

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Signal Transduct Target Ther. 2023 Apr 10;8(1):152. doi: 10.1038/s41392-023-01400-z.ABSTRACTVascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with diabetes. Diabetic panvascular disease (DPD) is a clinical syndrome in which vessels of various sizes, including macrovessels and microvessels in the cardiac, cerebral, renal, ophthalmic, and peripheral systems of patients with diabetes, develop atherosclerosis as a common pathology. Pathological manifestations of DPDs ...
Source: Atherosclerosis - April 10, 2023 Category: Cardiology Authors: Yiwen Li Yanfei Liu Shiwei Liu Mengqi Gao Wenting Wang Keji Chen Luqi Huang Yue Liu Source Type: research

Does metformin improve vascular heath in children with type 1 diabetes? Protocol for a one year, double blind, randomised, placebo controlled trial
This study aims to assess the effect of metformin on vascular health in children with T1D. Methods: This study is a 12 month, double blind, randomised, placebo controlled trial to determine the effect of metformin on vascular health in children (age 8--18) with T1D. The sample size is 76 with 38 children in the metformin group and 38 children in the placebo group. Vascular health and biochemical markers will be measured at baseline, 3, 6 and 12 months. Vascular function will be measured using flow mediated dilatation and glyceryl trinitrate mediated dilatation of the brachial artery and vascular structure will be measured ...
Source: BMC Pediatrics - Latest articles - July 16, 2013 Category: Pediatrics Authors: Jemma AndersonAlexia PeñaThomas SullivanRoger GentBronwen D¿ArcyTimothy OldsBrian CoppinJennifer Couper Source Type: research

Hyperglycemia‐Mediated Oxidative Stress Increases Pulmonary Vascular Permeability
ConclusionsThese data suggest that hyperglycemia in metabolic syndrome exacerbates lung vascular permeability through increases in vascular superoxide, possibly through NADPH oxidase.This article is protected by copyright. All rights reserved.
Source: Microcirculation - January 1, 2016 Category: Research Authors: John S. Clemmer, Lusha Xiang, Silu Lu, Peter N. Mittwede, Robert L. Hester Tags: Original Research Source Type: research

Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis
Exposure to fine particular matter (PM2.5) increases the risk of developing cardiovascular disease and Type 2 diabetes. Because blood vessels are sensitive targets of air pollutant exposure, we examined the effects of concentrated ambient PM2.5 (CAP) on vascular insulin sensitivity and circulating levels of endothelial progenitor cells (EPCs), which reflect cardiovascular health. We found that CAP exposure for 9 days decreased insulin-stimulated Akt phosphorylation in the aorta of mice maintained on control diet. This change was accompanied by the induction of IL-1β and increases in the abundance of cleaved IL-18 and ...
Source: AJP: Heart and Circulatory Physiology - May 31, 2016 Category: Cardiology Authors: Haberzettl, P., McCracken, J. P., Bhatnagar, A., Conklin, D. J. Tags: CALL FOR PAPERS Source Type: research

Calcification biomarkers and vascular dysfunction in obesity and type 2 diabetes: influence of oral hypoglycemic agents.
In conclusion, obese patients with MUO/T2D have elevated circulating OPN, OPG and RANTES; in these patients, antidiabetic treatment reduces only circulating OPG. Further study is needed to better understand the mechanisms of vascular calcifications in obesity and diabetes. PMID: 31408377 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - August 12, 2019 Category: Endocrinology Authors: Schinzari F, Tesauro M, Bertoli A, Valentini A, Veneziani A, Cambia U, Cardillo C Tags: Am J Physiol Endocrinol Metab Source Type: research

Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs.
Abstract The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence implicates adipose inflammation in the pathogenesis of insulin resistance and diabetes. It is not certain whether amelioration of adipose inflammation is sufficient to preclude vascular dysfunction in early stages of metabolic disease. Recent findings suggest that antidiabetic drugs, metformin, and pioglitazone, improve vascular function in prediabetic patients, without an indication if ...
Source: Translational Research : the journal of laboratory and clinical medicine - July 28, 2019 Category: Laboratory Medicine Authors: Elkhatib MAW, Mroueh A, Rafeh RW, Sleiman F, Fouad H, Saad EI, Fouda MA, Elgaddar O, Issa K, Eid AH, Eid AA, Abd-Elrahman KS, El-Yazbi AF Tags: Transl Res Source Type: research

Metformin upregulates the expression of Gli1 in vascular endothelial cells in hyperoxia-exposed neonatal mice.
Authors: Xiang X, Wang L, Zhou L, Chen Y, Xia H Abstract Bronchopulmonary dysplasia (BPD) is characterized by arrested alveolar and vascular development in premature infants. Metformin protects against the cardiovascular impairment induced by diabetes. The aim of this study was to investigate whether metformin could also enhance pulmonary vascular development in hyperoxic neonatal mice and investigate possible mechanisms involved. C57BL/6J newborn mice were randomly assigned to either of two groups - the room air group or the hyperoxia group - within 12 h postnatally. The mice were subcutaneously injected with metf...
Source: American Journal of Translational Research - November 18, 2020 Category: Research Tags: Am J Transl Res Source Type: research

Vascular phenotype at 35-37  weeks' gestation in women with gestational diabetes mellitus
CONCLUSION: Women with GDM have evidence of early vascular disease and this may contribute to their long-term cardiovascular risk. This article is protected by copyright. All rights reserved.PMID:36173400 | DOI:10.1002/uog.26077
Source: The Ultrasound Review of Obstetrics and Gynecology - September 29, 2022 Category: Radiology Authors: T Mansukhani A Arechvo F Cecchini M Breim A Wright K H Nicolaides M Charakida Source Type: research

Perivascular fat, AMP‐activated Protein Kinase and Vascular Diseases
Summary Perivascular adipose tissue (PVAT) is an active endocrine and paracrine organ that modulates vascular function with implications in the pathophysiology of cardiovascular disease (CVD). Adipocytes and stromal cells contained within PVAT produce mediators with varied paracrine effects that modulate vascular smooth muscle cell contraction, proliferation and migration including: adipokines, cytokines, reactive oxygen species, and gaseous compounds. However, the modulatory effect of PVAT on the vascular system in diseases such as obesity, hypertension and atherosclerosis remains poorly characterised. AMP‐activated pro...
Source: British Journal of Pharmacology - October 25, 2013 Category: Drugs & Pharmacology Authors: T A M Almabrouk, M A Ewart, I P Salt, S Kennedy Tags: Review Article Source Type: research

Ferulic acid combined with astragaloside IV protects against vascular endothelial dysfunction in diabetic rats.
In conclusion, ferulic acid combined with astragaloside IV exhibited significant protective effects against vascular endothelial dysfunction in diabetic rats through the NF-κB pathway involving decrease of Ox-LDL, increase of NO and eNOS, and activation of NF-κB P65, MCP-1 and TNF-α. PMID: 25224628 [PubMed - in process]
Source: BioScience Trends - December 1, 2014 Category: Biomedical Science Tags: Biosci Trends Source Type: research

Autophagy in Vascular Disease.
Abstract Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. Growing evidence reveals that basal autophagy is an essential in vivo process mediating proper vascular function. Moreover, autophagy is stimulated by many stress-related stimuli in the arterial wall to protect endothelial cells and smooth muscle cells against cell death and the initiation of vascular disease, in particular atherosclerosis. Basal autophagy is atheroprotective during early atherosclerosis but becomes dysfunctional...
Source: Circulation Research - January 30, 2015 Category: Cardiology Authors: De Meyer GR, Grootaert MO, Michiels CF, Kurdi A, Schrijvers DM, Martinet W Tags: Circ Res Source Type: research

Diabetes-mediated middle cerebral artery remodeling is restored by linagliptin: Interaction with the vascular smooth muscle cell endothelin system
Conclusions Linagliptin is effective in reversing established pathological cerebrovascular remodeling associated with diabetes. Attenuation of the ET system could be a pleiotropic effect of linagliptin that provides vascular protection.
Source: Life Sciences - March 3, 2016 Category: Biology Source Type: research

Metformin prevents vascular prostanoid release alterations induced by a high ‐fat diet in rats
In conclusion, metformin could exert beneficial effects on adipose tissue and the vascular system by improving endothelial dysfunction induced by an imbalance of vasoactive substances in mesenteric perivascular adipose tissue in this model.
Source: Autonomic and Autacoid Pharmacology - March 1, 2017 Category: Drugs & Pharmacology Authors: H. J. Lee, S. M. Cant ú, A. S. Donoso, M. R. Choi, H. A. Peredo, A. M. Puyó Tags: ORIGINAL ARTICLE Source Type: research

Effect of Metformin on vascular function in children with type 1 diabetes: A 12 month randomized controlled trial.
Conclusions: Metformin improved vascular smooth muscle function and HbA1c, and lowered insulin dose in type 1 diabetes children. These benefits and good safety profile warrant further consideration of its use. Trial Registration: ACTRN12611000148976 http://www.anzctr.org.au/. PMID: 29040598 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 9, 2017 Category: Endocrinology Authors: Anderson JJA, Couper JJ, Giles LC, Leggett CE, Gent R, Coppin B, Peña AS Tags: J Clin Endocrinol Metab Source Type: research