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Drug: Dexamethasone

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Total 7130 results found since Jan 2013.

Inhibition of SUR1 Decreases the Vascular Permeability of Cerebral Metastases.
Abstract Inhibition of sulfonylurea receptor 1 (SUR1) by glyburide has been shown to decrease edema after subarachnoid hemorrhage. We investigated if inhibiting SUR1 reduces cerebral edema due to metastases, the most common brain tumor, and explored the putative association of SUR1 and the endothelial tight junction protein, zona occludens-1 (ZO-1). Nude rats were intracerebrally implanted with small cell lung carcinoma (SCLC) LX1 or A2058 melanoma cells (n = 36). Rats were administered vehicle, glyburide (4.8 µg twice, orally), or dexamethasone (0.35 mg, intravenous). Blood-tumor barrier (BTB) permeability (K (t...
Source: Neoplasia - May 1, 2013 Category: Cancer & Oncology Authors: Thompson EM, Pishko GL, Muldoon LL, Neuwelt EA Tags: Neoplasia Source Type: research

Vascular Changes in Eyes Treated with Dexamethasone Intravitreal Implant for Macular Edema after Retinal Vein Occlusion
Conclusions: This study demonstrated that the clinical improvements observed with the DEX implant were accompanied by significant improvements in vascular parameters and suggests that treatment with the DEX implant may be associated with some clinically significant improvements in angiographic findings, specifically active neovascularization. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.
Source: Ophthalmology - March 15, 2013 Category: Opthalmology Authors: SriniVas Sadda, Ronald P. Danis, Rajeev R. Pappuru, Pearse A. Keane, Jenny Jiao, Xiao-Yan Li, Scott M. Whitcup Tags: Original Articles Source Type: research

Adjunctive Dexamethasone Infusion into the Adventitia of the Femoro-popliteal Artery to Enhance Clinical Efficacy Following Endovascular Revascularization: A Proof of Concept First in Man Study
Restenosis following peripheral intervention is in part an inflammatory disease. We hypothesize that a non-stent-based local drug delivery of the anti-inflammatory corticosteroid dexamethasone (DEX) would mitigate intervention-associated inflammation and thus improve long-term arterial patency.
Source: Journal of Vascular Surgery - July 27, 2013 Category: Surgery Authors: Christopher D. Owens, Warren Gasper, Hugh F. Alley, Karen C. Chong, Joseph H. Rapp, Michael S. Conte, Kirk Seward, Marlene S. Grenon Tags: Abstracts from the 2013 Western Vascular Society Annual Meeting Source Type: research

Safety and Efficacy of Dexamethasone Intravitreal Implant (Ozurdex) for the Treatment of Persistent Macular Edema Secondary to Retinal Vein Occlusion in Eyes Previously Treated with Anti-Vascular Endothelial Growth Factors.
Conclusions: Provided the complexity of molecular mechanisms involved in ΜΕ development and the effect of corticosteroids on many of these mechanisms, in our case series, Ozurdex appeared to be a safe and beneficial treatment option for persistent ME due to RVO, in patients with poor or complete lack of response after at least 3 consecutive monthly intravitreal anti-VEGF injections. The complication rate of cataract reported in our study is relatively high compared to previous reports. This might be attributed to the multiple injections, as the incidence of cataract increases with time. Regarding IOP elevation, there is ...
Source: Current Drug Safety - August 5, 2014 Category: Drugs & Pharmacology Authors: Tservakis I, Koutsandrea C, Papaconstantinou D, Paraskevopoulos T, Georgalas I Tags: Curr Drug Saf Source Type: research

Effects of a single course versus repeated courses of antenatal corticosteroids on fetal growth, placental morphometry and the differential regulation of vascular endothelial growth factor
ConclusionRepeated antenatal courses of DEX compromised fetal and placental growth compared with a single course of DEX, and these effects were potentially mediated by altered maternal plasma levels and placental expression of VEGF with consequent decrease in placental vascularization. Because of continuing uncertainties, several key messages for clinicians are provided.
Source: Journal of Obstetrics and Gynaecology Research - August 28, 2014 Category: OBGYN Authors: Amr K. Elfayomy, Shaima M. Almasry Tags: Original Article Source Type: research

Macular and optic disc edema and retinal vascular leakage in familial amyloid polyneuropathy with a transthyretin Val30Met mutation: a case report
Conclusions To the best of our knowledge, this is the first report of a rare ocular manifestation of familial amyloid polyneuropathy which represents a new therapeutic challenge. Intravitreal injection of sustained release dexamethasone implant and panretinal photocoagulation may be an effective eye-saving therapeutic approach.
Source: Journal of Medical Case Reports - October 4, 2014 Category: Journals (General) Source Type: research

Outcomes of combination therapy with dexamethasone implant and bevacizumab in macular edema related to vascular occlusions
Conclusion This study demonstrates that the combination therapy of bevacizumab and dexamethasone implant given simultaneously is safe and synergistic resulting in significantly early and sustained visual recovery and decreased macular edema in patients having retinal vein occlusions.
Source: Taiwan Journal of Ophthalmology - November 7, 2014 Category: Opthalmology Source Type: research

Th17 inflammation and pulmonary hypertension
Conclusions: We highlighted a Th17 immune polarization in PAH patient; a polarization involved in several chronic inflammatory and autoimmune conditions.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Hautefort, A., Girerd, B., Montani, D., Humbert, M., Perros, F. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Nuclear factor-kappa B inhibition exerts anti-remodelling effects in pulmonary arterial smooth muscle cells
Conclusion Inhibition of NF-kB exerts anti-remodelling cellular effects in human PASMC and may be an important future therapy in PAH.Figure IKK2 inhibition reduced TNF-α-stimulated IL-6 release from human PASMC (left) and induced apoptosis (right).Mean±SEM for n=4), *p<0.05, ***p<0.001.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Price, L., Shao, D., Meng, C., Perros, F., Montani, D., Dorfmuller, P., Humbert, M., Adcock, I., Wort, J. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids
Maternal undernutrition increases maternal glucocorticoids (GCs) and alters microRNA expression in offspring. Given that the mechanisms of GC action on vascular development are not clear, this study examined the influence of GCs on microRNA 29c (miR-29c) and its predicted targets in primary rat aorta smooth muscle cells (RAOSMCs). Dexamethasone (Dex) and corticosterone (Cor) time-dependently increased miR-29c expression and reduced collagen type III (Col3A1), collagen type IV (Col4A5), elastin (ELN), and matrix metalloproteinase-2 (MMP2) protein in RAOSMCs. These effects were blocked by mifepristone. These genes were also ...
Source: AJP: Cell Physiology - July 15, 2015 Category: Cytology Authors: Chuang, T.-D., Pearce, W. J., Khorram, O. Tags: ARTICLES Source Type: research

Presurgical Psychological and Neuroendocrine Predictors of Psychiatric Morbidity After Major Vascular Surgery: A Prospective Longitudinal Study
Objectives: Major life stressors, including major surgeries, are often followed by psychiatric symptoms and disorders. Prior retrospective work found abdominal aortic aneurysm (AAA) repair is followed by increased psychiatric morbidity, which may adversely influence physical and functional recovery. Identifying risk factors before surgery, such as dysregulation in stress response systems, might be useful in improving preventative intervention. Methods: Two hundred sixteen patients receiving open AAA or aortofemoral bypass surgeries, endovascular AAA repair, or nonsurgical AAA treatment were recruited from two vascular surg...
Source: Psychosomatic Medicine - November 1, 2015 Category: Psychiatry & Psychology Tags: Original Articles Source Type: research

High-dose glucocorticoids increases the expression of mineralocorticoid receptor in vascular endothelial cells.
CONCLUSIONS: Large dose of DEX (10-6 mol/l) up-regulated the expression of MR and GR in the reduction of the contrast exactly. GC induced the expression of GR and MR in different changes of stress injury of the body may be a regulatory mechanism, and indicate one new mechanism of glucocorticoid exist. PMID: 26636519 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 6, 2015 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

INTRAVITREAL DEXAMETHASONE IMPLANT FOR THE TREATMENT OF REFRACTORY MACULAR EDEMA IN RETINAL VASCULAR DISEASES: Results of the KKESH International Collaborative Retina Study Group
Purpose: To evaluate the safety and efficacy of intravitreal dexamethasone implant (Ozurdex) for treating refractory macular edema in retinal vascular diseases. Methods: This is a retrospective consecutive series of 53 eyes with refractory macular edema secondary to central retinal vein occlusion (13 eyes), branch retinal vein occlusion (14 eyes), and diabetic macular edema (26 eyes) treated with a single 0.7 mg dexamethasone implant. Data were collected on best-corrected visual acuity, intraocular pressure, and central macular thickness preoperatively and at 1, 3, and 6 months postoperatively. Results: Baseline best-corre...
Source: RETINA - December 28, 2015 Category: Opthalmology Tags: Original Study Source Type: research

Hyperreflective foci as an independent visual outcome predictor in macular edema due to retinal vascular diseases treated with intravitreal dexamethasone or ranibizumab
Purpose: To evaluate the potential role of hyperreflective foci (HF) in predicting visual outcome in patients undergoing treatment for macular edema due to retinal vascular diseases. Methods: Data and images of 92 patients with macular edema due to diabetes mellitus or branch retinal vein occlusion, treated with either intravitreal dexamethasone implant or ranibizumab, were analyzed. All patients underwent best-corrected visual acuity measurement, slit-lamp examination, spectral domain optical coherence tomography at baseline and at all time points of the follow-up (Month 1, 2, 3, 6, and 9). Generalized least squares rand...
Source: RETINA - November 19, 2016 Category: Opthalmology Tags: Original Study Source Type: research

Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms
The objective of this study was to determine the underlying mechanism by which glucocorticoids (GCs) induce of miR-29c expression in vascular smooth muscle cells. Main methods QRT-PCR was used for miR-29c detection. Protein levels were determined by western blotting. Knockdown of SP1, DNMT1 and DNMT3A was achieved through transfection with their specific respective siRNAs. The effect of GCs on SP1 activity was determined by luciferase reporter assay and the methylation status in miR-29c promoter was detected by methylation specific PCR. CHIP assay was used to determine the binding ability of SP1 and glucocorticoid receptor...
Source: Life Sciences - August 12, 2017 Category: Biology Source Type: research